Search Results - "Stuart, G G"

Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease by Cull‐Candy, Stuart G., Farrant, Mark

“…AMPA receptors are tetrameric glutamate‐gated ion channels that mediate a majority of fast excitatory neurotransmission in the brain. They exist as…”
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Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection by Tangye, Stuart G., Latour, Sylvain

“…Epstein-Barr virus (EBV) is an enigma; on one hand, it infects and persists in latent form in the vast majority of the global population, causing relatively…”
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Genetic susceptibility to EBV infection: insights from inborn errors of immunity by Tangye, Stuart G.

“…Epstein–Barr virus (EBV) is a ubiquitous human pathogen, infecting > 90% of the adult population. In the vast majority of healthy individuals, infection with…”
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Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage by Moens, Leen, Tangye, Stuart G

“…During our life, we are surrounded by continuous threats from a diverse range of invading pathogens. Our immune system has evolved multiple mechanisms to…”
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Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee by Tangye, Stuart G., Al-Herz, Waleed, Bousfiha, Aziz, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M., Klein, Christoph, Morio, Tomohiro, Ochs, Hans D., Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Torgerson, Troy R., Casanova, Jean-Laurent, Sullivan, Kathleen E.

“…We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies…”
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For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity by Tangye, Stuart G

“…In this issue of JEM, Çakan et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230944) explore a CXCL4-mediated mechanism by which TLRs cause autoimmunity…”
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Regulation of the germinal center and humoral immunity by interleukin-21 by Tangye, Stuart G, Ma, Cindy S

“…Cytokines play critical roles in regulating the development, survival, differentiation, and function of immune cells. Cytokines exert their function by binding…”
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Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study by Snowden, Stuart G, Ebshiana, Amera A, Hye, Abdul, An, Yang, Pletnikova, Olga, O'Brien, Richard, Troncoso, John, Legido-Quigley, Cristina, Thambisetty, Madhav

“…The metabolic basis of Alzheimer disease (AD) pathology and expression of AD symptoms is poorly understood. Omega-3 and -6 fatty acids have previously been…”
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Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification by Bousfiha, Aziz, Jeddane, Leila, Picard, Capucine, Al-Herz, Waleed, Ailal, Fatima, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D., Oksenhendler, Eric, Puck, Jennifer, Torgerson, Troy R., Casanova, Jean-Laurent, Sullivan, Kathleen E., Tangye, Stuart G.

“…Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated…”
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Do multiple subsets of CD11c+ B cells exist? You (T)-Bet by Tangye, Stuart G.

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Human immunity against EBV-lessons from the clinic by Tangye, Stuart G, Palendira, Umaimainthan, Edwards, Emily S J

“…The mammalian immune system has evolved over many millennia to be best equipped to protect the host from pathogen infection. In many cases, host and pathogen…”
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Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV) by Lefkowitz, Elliot J, Dempsey, Donald M, Hendrickson, Robert Curtis, Orton, Richard J, Siddell, Stuart G, Smith, Donald B

“…Abstract The International Committee on Taxonomy of Viruses (ICTV) is charged with the task of developing, refining, and maintaining a universal virus…”
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XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP by Tangye, Stuart G

“…X-linked lymphoproliferative disease (XLP) is a rare primary immunodeficiency affecting approximately 1–2 per 1 million males. A key feature of XLP is the…”
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The case for a cancer paradox initiative by Baker, Stuart G

“…Graphical Abstract…”
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Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins by Greger, Ingo H., Watson, Jake F., Cull-Candy, Stuart G.

“…AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a…”
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Advances in IL-21 biology — enhancing our understanding of human disease by Tangye, Stuart G

“…Highlights • IL-21 is pleiotropic and exerts potent effects on most populations of murine and human lymphocytes. • Models of autoimmunity revealed a critical…”
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Evaluating Risk Prediction with Data Collection Costs: Novel Estimation of Test Tradeoff Curves by Baker, Stuart G.

“…Background The test tradeoff curve helps investigators decide if collecting data for risk prediction is worthwhile when risk prediction is used for treatment…”
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The Ever-Increasing Array of Novel Inborn Errors of Immunity: an Interim Update by the IUIS Committee by Tangye, Stuart G., Al-Herz, Waleed, Bousfiha, Aziz, Cunningham-Rundles, Charlotte, Franco, Jose Luis, Holland, Steven M, Klein, Christoph, Morio, Tomohiro, Oksenhendler, Eric, Picard, Capucine, Puel, Anne, Puck, Jennifer, Seppänen, Mikko R. J., Somech, Raz, Su, Helen C, Sullivan, Kathleen E., Torgerson, Troy R., Meyts, Isabelle

“…The most recent updated classification of inborn errors of immunity/primary immunodeficiencies, compiled by the International Union of Immunological Societies…”
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High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials by Higgins, Stuart G., Becce, Michele, Belessiotis‐Richards, Alexis, Seong, Hyejeong, Sero, Julia E., Stevens, Molly M.

“…Materials patterned with high‐aspect‐ratio nanostructures have features on similar length scales to cellular components. These surfaces are an extreme…”
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Staying alive: regulation of plasma cell survival by Tangye, Stuart G

“…On describing the catastrophic effect of the plague during the Peloponnesian War, Greek historian Thucydides (c ∼450 BC) made the prescient observation that…”
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