Search Results - "Stuart, Erica"

Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease by Walsh, Daniel J, Rees, Judy R, Mehra, Surabhi, Bourkas, Matthew E C, Kaczmarczyk, Lech, Stuart, Erica, Jackson, Walker S, Watts, Joel C, Supattapone, Surachai

“…Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious…”
Get full text

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression by Ruiz-Riquelme, Alejandro, Lau, Heather H C, Stuart, Erica, Goczi, Adrienn N, Wang, Zhilan, Schmitt-Ulms, Gerold, Watts, Joel C

“…The amyloid cascade hypothesis posits that the initiating event in Alzheimer's disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide,…”
Get full text

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease by Lau, Heather H C, Martinez-Valbuena, Ivan, So, Raphaella W L, Mehra, Surabhi, Silver, Nicholas R G, Mao, Alison, Stuart, Erica, Schmitt-Ulms, Cian, Hyman, Bradley T, Ingelsson, Martin, Kovacs, Gabor G, Watts, Joel C

“…Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the…”
Get full text

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice by Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M, Lau, Heather H C, Stuart, Erica, Kovacs, Gabor G, Nilsson, K Peter R, Fraser, Paul E, Schmitt-Ulms, Gerold, Watts, Joel C

“…When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer's disease (AD) patients or transgenic AD…”
Get full text

α-Synuclein strains target distinct brain regions and cell types by Lau, Angus, So, Raphaella W. L., Lau, Heather H. C., Sang, Jason C., Ruiz-Riquelme, Alejandro, Fleck, Shelaine C., Stuart, Erica, Menon, Sindhu, Visanji, Naomi P., Meisl, Georg, Faidi, Rania, Marano, Maria M., Schmitt-Ulms, Cian, Wang, Zhilan, Fraser, Paul E., Tandon, Anurag, Hyman, Bradley T., Wille, Holger, Ingelsson, Martin, Klenerman, David, Watts, Joel C.

“…The clinical and pathological differences between synucleinopathies such as Parkinson’s disease and multiple system atrophy have been postulated to stem from…”
Get full text

Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model by So, Raphaella W. L, Amano, Genki, Stuart, Erica, Ebrahim Amini, Aeen, Aguzzi, Adriano, Collingridge, Graham L, Watts, Joel C

“…The cellular prion protein, PrP.sup.C, has been postulated to function as a receptor for [alpha]-synuclein, potentially facilitating cell-to-cell spreading…”
Get full text

Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease by Daniel J Walsh, Judy R Rees, Surabhi Mehra, Matthew E C Bourkas, Lech Kaczmarczyk, Erica Stuart, Walker S Jackson, Joel C Watts, Surachai Supattapone

“…Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious…”
Get full text

α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model by So, Raphaella W L, Amano, Genki, Stuart, Erica, Ebrahim Amini, Aeen, Aguzzi, Adriano, Collingridge, Graham L, Watts, Joel C

“…The cellular prion protein, PrPC, has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or…”
Get full text

Convergent generation of atypical prions in knockin mouse models of genetic prion disease by Mehra, Surabhi, Bourkas, Matthew Ec, Kaczmarczyk, Lech, Stuart, Erica, Arshad, Hamza, Griffin, Jennifer K, Frost, Kathy L, Walsh, Daniel J, Supattapone, Surachai, Booth, Stephanie A, Jackson, Walker S, Watts, Joel C

“…Most cases of human prion disease arise due to spontaneous misfolding of WT or mutant prion protein, yet recapitulating this event in animal models has proven…”
Get full text

Synuclein strains target distinct brain regions and cell types by Lau, Angus, So, Raphaella W. L, Lau, Heather H. C, Sang, Jason C, Ruiz-Riquelme, Alejandro, Fleck, Shelaine C, Stuart, Erica

“…The clinical and pathological differences between synucleinopathies such as Parkinson's disease and multiple system atrophy have been postulated to stem from…”
Get full text

The G51D SNCA mutation generates a slowly progressive [alpha]-synuclein strain in early-onset Parkinson's disease by Mehra, Surabhi, Ingelsson, Martin, Kovacs, Gabor G, Martinez-Valbuena, Ivan, So, Raphaella W. L, Stuart, Erica, Silver, Nicholas R. G, Hyman, Bradley T, Schmitt-Ulms, Cian, Lau, Heather H. C, Watts, Joel C, Mao, Alison

“…Unique strains of [alpha]-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the…”
Get full text

A beta 43 aggregates exhibit enhanced prion-like seeding activity in mice by Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M., Lau, Heather H. C., Stuart, Erica, Kovacs, Gabor G., Nilsson, Peter, Fraser, Paul E., Schmitt-Ulms, Gerold, Watts, Joel C.

“…When injected into genetically modified mice, aggregates of the amyloid-beta (A beta) peptide from the brains of Alzheimers disease (AD) patients or transgenic…”
Get full text

A[beta]43 aggregates exhibit enhanced prion-like seeding activity in mice by Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M, Lau, Heather H. C, Stuart, Erica, Kovacs, Gabor G, Nilsson, K. Peter R, Fraser, Paul E, Schmitt-Ulms, Gerold, Watts, Joel C

“…When injected into genetically modified mice, aggregates of the amyloid-[beta] (A[beta]) peptide from the brains of Alzheimer's disease (AD) patients or…”
Get full text

Prion-like propagation of [beta]-amyloid aggregates in the absence of APP overexpression by Ruiz-Riquelme, Alejandro, Lau, Heather H. C, Stuart, Erica, Goczi, Adrienn N, Wang, Zhilan, Schmitt-Ulms, Gerold, Watts, Joel C

“…The amyloid cascade hypothesis posits that the initiating event in Alzheimer's disease (AD) is the aggregation and deposition of the [beta]-amyloid (A[beta])…”
Get full text