Search Results - "Stuart, David I."

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection by Ren, Jingshan, Zhao, Yuguang, Fry, Elizabeth E, Stuart, David I

“…Here, we show that four chemically divergent approved drugs reported to inhibit Ebolavirus infection, benztropine, bepridil, paroxetine and sertraline,…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes by Ilca, Serban L., Kotecha, Abhay, Sun, Xiaoyu, Poranen, Minna M., Stuart, David I., Huiskonen, Juha T.

“…Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered macromolecular complexes. Often however some subunits bind in a flexible…”
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Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins by Elegheert, Jonathan, Behiels, Ester, Bishop, Benjamin, Scott, Suzanne, Woolley, Rachel E., Griffiths, Samuel C., Byrne, Eamon F. X., Chang, Veronica T., Stuart, David I., Jones, E. Yvonne, Siebold, Christian, Aricescu, A. Radu

“…Structural, biochemical and biophysical studies of eukaryotic soluble and membrane proteins require their production in milligram quantities. Although…”
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Hepatitis A virus and the origins of picornaviruses by Wang, Xiangxi, Ren, Jingshan, Gao, Qiang, Hu, Zhongyu, Sun, Yao, Li, Xuemei, Rowlands, David J., Yin, Weidong, Wang, Junzhi, Stuart, David I., Rao, Zihe, Fry, Elizabeth E.

“…Hepatitis A virus is a picornavirus that causes significant morbidity but remains poorly understood; this paper now provides high-resolution crystal structures…”
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Crystal structure of the RNA-dependent RNA polymerase from influenza C virus by Hengrung, Narin, El Omari, Kamel, Serna Martin, Itziar, Vreede, Frank T., Cusack, Stephen, Rambo, Robert P., Vonrhein, Clemens, Bricogne, Gérard, Stuart, David I., Grimes, Jonathan M., Fodor, Ervin

“…The X-ray crystal structure of influenza C virus polymerase, captured in a closed, pre-activation confirmation, is solved at 3.9 Å resolution; comparison with…”
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Structure of Bovine CD46 Ectodomain by Aitkenhead, Hazel, Stuart, David I, El Omari, Kamel

“…CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement…”
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Cryogenic electron ptychographic single particle analysis with wide bandwidth information transfer by Pei, Xudong, Zhou, Liqi, Huang, Chen, Boyce, Mark, Kim, Judy S., Liberti, Emanuela, Hu, Yiming, Sasaki, Takeo, Nellist, Peter D., Zhang, Peijun, Stuart, David I., Kirkland, Angus I., Wang, Peng

“…Advances in cryogenic transmission electron microscopy have revolutionised the determination of many macromolecular structures at atomic or near-atomic…”
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Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability by Wang, Xiangxi, Li, Shi-Hua, Zhu, Ling, Nian, Qing-Gong, Yuan, Shuai, Gao, Qiang, Hu, Zhongyu, Ye, Qing, Li, Xiao-Feng, Xie, Dong-Yang, Shaw, Neil, Wang, Junzhi, Walter, Thomas S., Huiskonen, Juha T., Fry, Elizabeth E., Qin, Cheng-Feng, Stuart, David I., Rao, Zihe

“…Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths…”
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Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine by Marsian, Johanna, Fox, Helen, Bahar, Mohammad W., Kotecha, Abhay, Fry, Elizabeth E., Stuart, David I., Macadam, Andrew J., Rowlands, David J., Lomonossoff, George P.

“…Poliovirus (PV) is the causative agent of poliomyelitis, a crippling human disease known since antiquity. PV occurs in two distinct antigenic forms, D and C,…”
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Structure Unifies the Viral Universe by Abrescia, Nicola G.A, Bamford, Dennis H, Grimes, Jonathan M, Stuart, David I

“…Is it possible to meaningfully comprehend the diversity of the viral world? We propose that it is. This is based on the observation that, although there is…”
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A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71 by Wang, Xiangxi, Peng, Wei, Ren, Jingshan, Hu, Zhongyu, Xu, Jiwei, Lou, Zhiyong, Li, Xumei, Yin, Weidong, Shen, Xinliang, Porta, Claudine, Walter, Thomas S, Evans, Gwyndaf, Axford, Danny, Owen, Robin, Rowlands, David J, Wang, Junzhi, Stuart, David I, Fry, Elizabeth E, Rao, Zihe

“…Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of…”
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Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen by Porta, Claudine, Kotecha, Abhay, Burman, Alison, Jackson, Terry, Ren, Jingshan, Loureiro, Silvia, Jones, Ian M, Fry, Elizabeth E, Stuart, David I, Charleston, Bryan

“…Foot-and-mouth disease remains a major plague of livestock and outbreaks are often economically catastrophic. Current inactivated virus vaccines require…”
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Machining protein microcrystals for structure determination by electron diffraction by Duyvesteyn, Helen M. E., Kotecha, Abhay, Ginn, Helen M., Hecksel, Corey W., Beale, Emma V., de Haas, Felix, Evans, Gwyndaf, Zhang, Peijun, Chiu, Wah, Stuart, David I.

“…We demonstrate that ion-beam milling of frozen, hydrated protein crystals to thin lamella preserves the crystal lattice to near-atomic resolution. This…”
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Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry by El Omari, Kamel, Iourin, Oleg, Harlos, Karl, Grimes, Jonathan M., Stuart, David I.

“…Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve…”
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Assembly intermediates of orthoreovirus captured in the cell by Sutton, Geoff, Sun, Dapeng, Fu, Xiaofeng, Kotecha, Abhay, Hecksel, Corey W., Clare, Daniel K., Zhang, Peijun, Stuart, David I., Boyce, Mark

“…Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of…”
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Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus by Kotecha, Abhay, Wang, Quan, Dong, Xianchi, Ilca, Serban L., Ondiviela, Marina, Zihe, Rao, Seago, Julian, Charleston, Bryan, Fry, Elizabeth E., Abrescia, Nicola G. A., Springer, Timothy A., Huiskonen, Juha T., Stuart, David I.

“…Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally αvβ6, via a conserved arginine–glycine–aspartic acid…”
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Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy by Ragonnet-Cronin, Manon, Nutalai, Rungtiwa, Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Das, Raksha, Tuekprakhon, Aekkachai, Supasa, Piyada, Liu, Chang, Selvaraj, Muneeswaran, Groves, Natalie, Hartman, Hassan, Ellaby, Nicholas, Mark Sutton, J., Bahar, Mohammad W., Zhou, Daming, Fry, Elizabeth, Ren, Jingshan, Brown, Colin, Klenerman, Paul, Dunachie, Susanna J., Mongkolsapaya, Juthathip, Hopkins, Susan, Chand, Meera, Stuart, David I., Screaton, Gavin R., Rokadiya, Sakib

“…COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these…”
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Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library by Shaikh, Faraz, Zhao, Yuguang, Alvarez, Luis, Iliopoulou, Maria, Lohans, Christopher, Schofield, Christopher J, Padilla-Parra, Sergi, Siu, Shirley W. I, Fry, Elizabeth E, Ren, Jingshan, Stuart, David I

“…Potent Ebolavirus (EBOV) inhibitors will help to curtail outbreaks such as that which occurred in 2014–16 in West Africa. EBOV has on its surface a single…”
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Atomic structure of the Epstein-Barr virus portal by Machón, Cristina, Fàbrega-Ferrer, Montserrat, Zhou, Daming, Cuervo, Ana, Carrascosa, José L., Stuart, David I., Coll, Miquel

“…Herpesviridae is a vast family of enveloped DNA viruses that includes eight distinct human pathogens, responsible for diseases that range from almost…”
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