Search Results - "Stuart, David"

Aryl Transfer Selectivity in Metal‐Free Reactions of Unsymmetrical Diaryliodonium Salts by Stuart, David R.

“…Aromatic rings are found in a wide variety of products, including pharmaceuticals, agrochemicals, and functional materials. Diaryliodonium salts are new…”
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Catalytic Cross-Coupling of Unactivated Arenes by Stuart, David R, Fagnou, Keith

“…The industrially important coupling of aromatic compounds has generally required differential prefunctionalization of the arene coupling partners with a halide…”
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Elements of Regiocontrol in Palladium-Catalyzed Oxidative Arene Cross-Coupling by Stuart, David R, Villemure, Elisia, Fagnou, Keith

“…By changing the stoichiometric oxidant and modifying the indole N-substituent in palladium-catalyzed oxidative arene cross-coupling reactions, both C2 and C3…”
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Antibody evasion by the P.1 strain of SARS-CoV-2 by Dejnirattisai, Wanwisa, Zhou, Daming, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, López-Camacho, César, Slon-Campos, Jose, Walter, Thomas S., Skelly, Donal, Costa Clemens, Sue Ann, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah C., Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Paterson, Neil G., Williams, Mark A., Hall, David R., Hulswit, Ruben J.G., Bowden, Thomas A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from…”
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Metal-free Synthesis of Aryl Amines: Beyond Nucleophilic Aromatic Substitution by Sandtorv, Alexander H., Stuart, David R.

“…A mild and metal‐free approach to C−N coupling is described that employs diaryliodonium salt electrophiles and secondary aliphatic amine nucleophiles. This…”
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Vinyl Moiety as a Handle for Regiocontrol in the Preparation of Unsymmetrical 2,3-Aliphatic-Substituted Indoles and Pyrroles by Huestis, Malcolm P, Chan, Lina, Stuart, David R, Fagnou, Keith

“…Rho‐Rho‐Rho your boat: A rhodium catalyst effects the regioselective oxidative coupling of enynes with N‐aryl ureas (X=NR2) and N‐vinylacetamides (X=C(O)Me),…”
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Analysis of Benzenoid Substitution Patterns in Small Molecule Active Pharmaceutical Ingredients by Nilova, Aleksandra, Campeau, Louis-Charles, Sherer, Edward C, Stuart, David R

“…Previous analyses have revealed that benzenoid rings are prevalent scaffolds in active pharmaceutical ingredients (APIs). Here, we analyze the substitution…”
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Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection by Ren, Jingshan, Zhao, Yuguang, Fry, Elizabeth E, Stuart, David I

“…Here, we show that four chemically divergent approved drugs reported to inhibit Ebolavirus infection, benztropine, bepridil, paroxetine and sertraline,…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway by Kounatidis, Ilias, Stanifer, Megan L., Phillips, Michael A., Paul-Gilloteaux, Perrine, Heiligenstein, Xavier, Wang, Hongchang, Okolo, Chidinma A., Fish, Thomas M., Spink, Matthew C., Stuart, David I., Davis, Ilan, Boulant, Steeve, Grimes, Jonathan M., Dobbie, Ian M., Harkiolaki, Maria

“…Imaging of biological matter across resolution scales entails the challenge of preserving the direct and unambiguous correlation of subject features from the…”
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Synthesis of Arynes via Formal Dehydrogenation of Arenes by Roberts, Riley A., Metze, Bryan E., Nilova, Aleksandra, Stuart, David R.

“…Arynes offer immense potential for diversification of benzenoid rings, which occur in pharmaceuticals, agrochemicals, and liquid crystals. However, accessing…”
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Broadly neutralizing antibodies against COVID-19 by Zhou, Daming, Ren, Jingshan, Fry, Elizabeth E, Stuart, David I

“…The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of infections and millions of deaths, however, human monoclonal antibodies (mAbs)…”
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Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5 by Greenhill, Stuart David, Ranson, Adam, Fox, Kevin

“…Layer 5 contains the major projection neurons of the neocortex and is composed of two major cell types: regular spiking (RS) cells, which have cortico-cortical…”
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Assembly intermediates of orthoreovirus captured in the cell by Sutton, Geoff, Sun, Dapeng, Fu, Xiaofeng, Kotecha, Abhay, Hecksel, Corey W., Clare, Daniel K., Zhang, Peijun, Stuart, David I., Boyce, Mark

“…Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of…”
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The effect of pH on the structure of Bluetongue virus VP5 by Zhang, Hanwen, El Omari, Kamel, Sutton, Geoff, Stuart, David I

“…The unenveloped Bluetongue virus capsid comprises several structural layers, the inner two comprising a core, which assembles before addition of the outer…”
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Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers by Gallagher, Rory T., Basu, Souradeep, Stuart, David R.

“…Herein, we describe a synthetic approach for arylation that exploits the in situ formation and reaction of an unsymmetrical diaryliodonium salt. In this way,…”
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Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes by Ilca, Serban L., Kotecha, Abhay, Sun, Xiaoyu, Poranen, Minna M., Stuart, David I., Huiskonen, Juha T.

“…Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered macromolecular complexes. Often however some subunits bind in a flexible…”
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Toremifene interacts with and destabilizes the Ebola virus glycoprotein by Zhao, Yuguang, Ren, Jingshan, Harlos, Karl, Jones, Daniel M., Zeltina, Antra, Bowden, Thomas A., Padilla-Parra, Sergi, Fry, Elizabeth E., Stuart, David I.

“…High-resolution structures of the unliganded Ebola virus glycoprotein (GP) and of GP bound to the drugs toremifene and ibuprofen are presented, providing…”
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Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen by Porta, Claudine, Kotecha, Abhay, Burman, Alison, Jackson, Terry, Ren, Jingshan, Loureiro, Silvia, Jones, Ian M, Fry, Elizabeth E, Stuart, David I, Charleston, Bryan

“…Foot-and-mouth disease remains a major plague of livestock and outbreaks are often economically catastrophic. Current inactivated virus vaccines require…”
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A Selective C−H Deprotonation Strategy to Access Functionalized Arynes by Using Hypervalent Iodine by Sundalam, Sunil K., Nilova, Aleksandra, Seidl, Thomas L., Stuart, David R.

“…Described here is an efficient method to access highly functionalized arynes from unsymmetrical aryl(mesityl)iodonium tosylate salts. The iodonium salts are…”
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