Search Results - "Stürup, Stefan"

Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies by Azmi, Intan Diana Mat, Østergaard, Jesper, Stürup, Stefan, Gammelgaard, Bente, Urtti, Arto, Moghimi, Seyed Moein, Yaghmur, Anan

“…Cisplatin (cis-di­ammine­di­chloro­platinum­(II)) is among the most potent cytotoxic agents used in cancer chemotherapy. The encapsulation of cisplatin in…”
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Modulatory Effect of Human Plasma on the Internal Nanostructure and Size Characteristics of Liquid-Crystalline Nanocarriers by Mat Azmi, Intan Diana, Wu, Linping, Wibroe, Peter Popp, Nilsson, Christa, Østergaard, Jesper, Stürup, Stefan, Gammelgaard, Bente, Urtti, Arto, Moghimi, Seyed Moein, Yaghmur, Anan

“…The inverted-type liquid-crystalline dispersions comprising cubosomes and hexosomes hold much potential for drug solubilization and site-specific targeting on…”
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Development and validation of an ICP-MS method for quantification of total carbon and platinum in cell samples and comparison of open-vessel and microwave-assisted acid digestion methods by Riisom, Mie, Gammelgaard, Bente, Lambert, Ian H., Stürup, Stefan

“…[Display omitted] •ICP-MS method for quantification of total carbon and platinum in cell samples.•Method was validated for LOD, LOQ, precision, accuracy and…”
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Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin by Han, Jiaying, Räder, Andreas F. B, Reichart, Florian, Aikman, Brech, Wenzel, Margot N, Woods, Ben, Weinmüller, Michael, Ludwig, Beatrice S, Stürup, Stefan, Groothuis, Geny M. M, Permentier, Hjalmar P, Bischoff, Rainer, Kessler, Horst, Horvatovich, Peter, Casini, Angela

“…Cisplatin occupies a crucial role in the treatment of various malignant tumors. However, its efficacy and applicability are heavily restricted by severe…”
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Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells by Sørensen, Belinda Halling, Dam, Celina Støving, Stürup, Stefan, Lambert, Ian Henry

“…Acquired resistance to chemotherapeutic drugs in cancer cells can reflect an ability to limit cellular drug availability, to repair drug induced DNA damage,…”
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Development and validation of an ICP-OES method for quantitation of elemental impurities in tablets according to coming US pharmacopeia chapters by Støving, Celina, Jensen, Henrik, Gammelgaard, Bente, Stürup, Stefan

“…•An ICP-OES method for quantification of elemental impurities in tablets is proposed.•Sample preparation was performed using microwave-assisted acid…”
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Distribution of platinum between nuclear and cytosolic fractions – Can subcellular fractionation be performed quantitatively? by Dam, Celina Støving, Lambert, Ian Henry, Gammelgaard, Bente, Stürup, Stefan

“…[Display omitted] •Cisplatin-exposed cells were fractionated into cytosol and nuclei.•Obtained nuclei were not contaminated with cytosol and vice versa.•18%…”
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Determination of trace elements in ibuprofen drug products using microwave-assisted acid digestion and inductively coupled plasma-mass spectrometry by Holmfred, Else, Alrijjal, Abdulla, Chamberlain, C. Page, Maher, Katharine, Stürup, Stefan

“…Trace elements are found in most drugs as a result of the drug formulation and drug production methods. An inductively coupled plasma-mass spectrometry method…”
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Determination of platinum drug release and liposome stability in human plasma by CE-ICP-MS by Nguyen, Tam T.T.N., Østergaard, Jesper, Stürup, Stefan, Gammelgaard, Bente

“…An in vitro method for simultaneous assessment of platinum release and liposome stability of liposomal formulations in human plasma is demonstrated. The…”
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Laser-assisted delivery enhances topical uptake of the anticancer agent cisplatin by Wenande, Emily, Olesen, Uffe H., Boesen, Malene R., Persson, Daniel P., Lerche, Catharina M., Stürup, Stefan, Gammelgaard, Bente, Husted, Søren, Anderson, R. Rox, Haedersdal, Merete

“…Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by…”
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Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin by Spreckelmeyer, Sarah, van der Zee, Margot, Bertrand, Benoît, Bodio, Ewen, Stürup, Stefan, Casini, Angela

“…The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated…”
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Quantification of low molecular weight selenium metabolites in human plasma after treatment with selenite in pharmacological doses by LC-ICP-MS by Flouda, Konstantina, Dersch, Julie Maria, Gabel-Jensen, Charlotte, Stürup, Stefan, Misra, Sougat, Björnstedt, Mikael, Gammelgaard, Bente

“…The paper presents an analytical method for quantification of low molecular weight (LMW) selenium compounds in human plasma based on liquid chromatography…”
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Application of enriched stable isotopes as tracers in biological systems: a critical review by Stürup, Stefan, Hansen, Helle Rüsz, Gammelgaard, Bente

“…The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits…”
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Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity by Perfahl, Stefanie, Bodtke, Anja, Pracharova, Jitka, Kasparkova, Jana, Brabec, Viktor, Cuadrado, Juan, Stürup, Stefan, Schulzke, Carola, Bednarski, Patrick J.

“…[Display omitted] •Transplatin was used to prepare trans-diamminoditetrazolato-Pt(II) derivatives.•Oxidation of ditetrazolato-Pt(II) complexes to Pt(IV)…”
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Complementary use of molecular and element-specific mass spectrometry for identification of selenium compounds related to human selenium metabolism by Gammelgaard, Bente, Gabel-Jensen, Charlotte, Stürup, Stefan, Hansen, Helle Rüsz

“…The aim of this paper is to give an overview of analytical data on the identification of selenium compounds in biological samples with relevance for selenium…”
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Investigation of a liposomal oxaliplatin drug formulation by capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry (CE-ICP-MS) by Nguyen, Tam T. T. N., Østergaard, Jesper, Stürup, Stefan, Gammelgaard, Bente

“…A capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS) method was developed for separation of the free oxaliplatin drug substance…”
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Metallomics in drug development: characterization of a liposomal cisplatin drug formulation in human plasma by CE–ICP–MS by Nguyen, Tam T. T. N., Østergaard, Jesper, Stürup, Stefan, Gammelgaard, Bente

“…A capillary electrophoresis inductively coupled plasma mass spectrometry method for separation of free cisplatin from liposome-encapsulated cisplatin and…”
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Cellular uptake of metallated cobalamins by Tran, Mai Thanh Quynh, Stürup, Stefan, Lambert, Ian Henry, Gammelgaard, Bente, Furger, Evelyne, Alberto, Roger

“…Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass…”
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On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent by Spreckelmeyer, Sarah, Estrada-Ortiz, Natalia, Prins, Gerian G. H, van der Zee, Margot, Gammelgaard, Bente, Stürup, Stefan, de Graaf, Inge A. M, Groothuis, Geny M. M, Casini, Angela

“…Mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated. Here, we studied…”
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Investigation of the selenium metabolism in cancer cell lines by Lunøe, Kristoffer, Gabel-Jensen, Charlotte, Stürup, Stefan, Andresen, Lars, Skov, Søren, Gammelgaard, Bente

“…The aim of this work was to compare different selenium species for their ability to induce cell death in different cancer cell lines, while investigating the…”
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