Search Results - "Struve, Melanie F"

Tissue Manganese Concentrations in Young Male Rhesus Monkeys following Subchronic Manganese Sulfate Inhalation by Dorman, David C., Struve, Melanie F., Marshall, Marianne W., Parkinson, Carl U., James, R. Arden, Wong, Brian A.

“…High-dose human exposure to manganese results in manganese accumulation in the basal ganglia and dopaminergic neuropathology. Occupational manganese…”
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Influence of Particle Solubility on the Delivery of Inhaled Manganese to the Rat Brain: Manganese Sulfate and Manganese Tetroxide Pharmacokinetics Following Repeated (14-Day) Exposure by Dorman, David C., Struve, Melanie F., James, R.Arden, Marshall, Marianne W., Parkinson, Carl U., Wong, Brian A.

“…Dissolution rate can influence the pulmonary clearance of a metal and thus affect its delivery to the brain and other organs. The goal of this study was to…”
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Reproductive toxicity and pharmacokinetics of di-n-butyl phthalate (DBP) following dietary exposure of pregnant rats by Struve, Melanie F., Gaido, Kevin W., Hensley, Janan B., Lehmann, Kim P., Ross, Susan M., Sochaski, Mark A., Willson, Gabrielle A., Dorman, David C.

“…Most rodent developmental toxicity studies of dibutylphthalate (DBP) have relied on bolus gavage dosing. This study characterized the developmental toxicity of…”
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Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats by Dorman, David C, McManus, Brian E, Marshall, Marianne W, James, R.Arden, Struve, Melanie F

“…In this study, we examined whether gender or age influences the pharmacokinetics of manganese sulfate (MnSO 4) or manganese phosphate (as the mineral form…”
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Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion by Struve, Melanie F., Turner, Katie J., Dorman, David C.

“…In vitro, the organophosphate insecticide fenitrothion is a potent competitive androgen receptor antagonist, whereas in vivo it affects the development of the…”
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Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure by Dorman, David C., Struve, Melanie F., Vitarella, Domenico, Byerly, Faera L., Goetz, Jennifer, Miller, Richard

“…The purpose of this study was to evaluate the relative sensitivity of neonatal and adult CD rats to manganese‐induced neurotoxicity. Identical oral manganese…”
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Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys by Dorman, David C, Struve, Melanie F, Gross, Elizabeth A, Wong, Brian A, Howroyd, Paul C

“…Neurotoxicity and pulmonary dysfunction are well-recognized problems associated with prolonged human exposure to high concentrations of airborne manganese…”
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Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague-Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure by DORMAN, David C, STRUVE, Melanie F, GROSS, Elizabeth A, BRENNEMAN, Karrie A

“…The goal of this study was to characterize the toxicity of hydrogen sulfide (H2S), including nasal and pulmonary effects, in adult male and female Fischer-344…”
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Correlation of Brain Magnetic Resonance Imaging Changes with Pallidal Manganese Concentrations in Rhesus Monkeys Following Subchronic Manganese Inhalation by Dorman, David C., Struve, Melanie F., Wong, Brian A., Dye, Janice A., Robertson, Ian D.

“…High-dose manganese exposure is associated with parkinsonism. Because manganese is paramagnetic, its relative distribution within the brain can be examined…”
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Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation by Struve, Melanie F., McManus, Brian E., Wong, Brian A., Dorman, David C.

“…Background Manganese neurotoxicity in humans is recognized as a form of parkinsonism with lesions occurring predominantly within the globus pallidus,…”
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Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: Correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium by DORMAN, David C, MOULIN, Frederic J.-M, MCMANUS, Brian E, MAHLE, Kristen C, JAMES, R. Arden, STRUVE, Melanie F

“…Hydrogen sulfide (H2S) is an important brain, lung, and nose toxicant. Inhibition of cytochrome oxidase is the primary biochemical effect associated with…”
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Metabolomic Analyses of Body Fluids after Subchronic Manganese Inhalation in Rhesus Monkeys by Dorman, David C., Struve, Melanie F., Norris, Amy, Higgins, Alan J.

“…Neurotoxicity is linked with high-dose manganese inhalation. There are few biomarkers that correlate with manganese exposure. Blood manganese concentrations…”
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Application of pharmacokinetic data to the risk assessment of inhaled manganese by Dorman, David C., Struve, Melanie F., Clewell, Harvey J., Andersen, Melvin E.

“…There is increased interest within the scientific community concerning the neurotoxicity of manganese owing in part to the use of methylcyclopentadienyl…”
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Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation by Dorman, David C., Struve, Melanie F., Wong, Brian A., Marshall, Marianne W., Gross, Elizabeth A., Willson, Gabrielle A.

“…The goal of this study was to characterize the respiratory tract toxicity of acrolein, including nasal and pulmonary effects, in adult male F344 rats. Animals…”
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Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice by Wetmore, Barbara A., Struve, Melanie F., Gao, Pu, Sharma, Sheela, Allison, Neil, Roberts, Kay C., Letinski, Daniel J., Nicolich, Mark J., Bird, Michael G., Dorman, David C.

“…Benzene is an important industrial chemical. At certain levels, benzene has been found to produce aplastic anemia, pancytopenia, myeloblastic anemia and…”
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Acute sodium tungstate inhalation is associated with minimal olfactory transport of tungsten ( 188W) to the rat brain by Radcliffe, Pheona M., Olabisi, Ayodele O., Wagner, Dean J., Leavens, Teresa, Wong, Brian A., Struve, Melanie F., Chapman, Gail D., Wilfong, Erin R., Dorman, David C.

“…Olfactory transport of represents an important mechanism for direct delivery of certain metals to the central nervous system (CNS). The objective of this study…”
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Nasal Uptake of Inhaled Acrolein in Rats by Struve, Melanie F., Wong, Victoria A., Marshall, Marianne W., Kimbell, Julia S., Schroeter, Jeffry D., Dorman, David C.

“…An improved understanding of the relationship between inspired concentration of the potent nasal toxicant acrolein and delivered dose is needed to support…”
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Tissue Manganese Concentrations in Lactating Rats and Their Offspring Following Combined in Utero and Lactation Exposure to Inhaled Manganese Sulfate by Dorman, David C., McElveen, Anna M., Marshall, Marianne W., Parkinson, Carl U., James, R. Arden, Struve, Melanie F., Wong, Brian A.

“…There is little information regarding the tissue distribution of manganese in neonates following inhalation. This study determined tissue manganese…”
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Derivation of an Inhalation Reference Concentration Based upon Olfactory Neuronal Loss in Male Rats following Subchronic Acetaldehyde Inhalation by Dorman, David C., Struve, Melanie F., Wong, Brian A., Gross, Elizabeth A., Parkinson, Carl, Willson, Gabrielle A., Tan, Yu-Mei, Campbell, Jerry L., Teeguarden, Justin G., Clewell, Harvey J., Andersen, Melvin E.

“…Acetaldehyde inhalation induces neoplastic and nonneoplastic responses in the rodent nasal cavity. This experiment further characterizes the dose-response…”
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Effects of in Utero Exposure to the Organophosphate Insecticide Fenitrothion on Androgen-Dependent Reproductive Development in the Crl:CD(SD)BR Rat by Turner, Katie J., Barlow, Norman J., Struve, Melanie F., Wallace, Duncan G., Gaido, Kevin W., Dorman, David C., Foster, Paul M. D.

“…Fenitrothion [0,0-dimethyl-O-(4-nitro-m-tolyl) phosphorothioate] is an organophosphate insecticide that has been shown to have antiandrogenic activity using in…”
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