Search Results - "Struts, Andrey V"

Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation by Brown, Michael F, Struts, Andrey V, Salgado, Gilmar F J, Martínez-Mayorga, Karina

“…X-ray and magnetic resonance approaches, though central to studies of G protein-coupled receptor (GPCR)-mediated signaling, cannot address GPCR protein…”
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Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation by Mertz, Blake, Struts, Andrey V., Feller, Scott E., Brown, Michael F.

“…Rhodopsin has served as the primary model for studying G protein-coupled receptors (GPCRs)—the largest group in the human genome, and consequently a primary…”
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Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy by Brown, Michael F., Salgado, Gilmar F.J., Struts, Andrey V.

“…Rhodopsin is a canonical member of class A of the G protein-coupled receptors (GPCRs) that are implicated in many of the drug interventions in humans and are…”
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Rhodopsin is a dynamically active receptor in lipid membranes by Struts, Andrey V., Ritter, Eglof, Fischer, Paul, Mertz, Blake, Bartl, Franz, Brown, Michael F.

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Solid-state NMR spectroscopy uncovers internal dynamics of antiviral compounds by Nath, Ankan, Lee, Soohyun, Molugu, Trivikram R., Wang, Jun, Struts, Andrey V., Brown, Michael F.

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Untangling the rivalry between cholesterol and antimicrobial peptides by Doole, Fathima T., Kit Chan, Chun, Sarkar, Daipayan, Struts, Andrey V., Singharoy, Abhishek, Brown, Michael F.

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Solid-state ²H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin by Struts, Andrey V., Salgado, Gilmar F. J., Brown, Michael F.

“…Rhodopsin is a canonical member of the family of G protein-coupled receptors, which transmit signals across cellular membranes and are linked to many drug…”
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Modulation of GPCR Rhodopsin Function by Membrane Lipids and Water by Weerasinghe, Nipuna, Fried, Steven D., Struts, Andrey V., Perera, Suchithranga M., Brown, Michael F.

“…G protein‐coupled receptors (GPCRs) are responsible for the transduction of signals across lipid membranes and are the largest family of targets (~35%) for…”
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Activation of the G‐Protein‐Coupled Receptor Rhodopsin by Water by Chawla, Udeep, Perera, Suchithranga M. D. C., Fried, Steven D. E., Eitel, Anna R., Mertz, Blake, Weerasinghe, Nipuna, Pitman, Michael C., Struts, Andrey V., Brown, Michael F.

“…Visual rhodopsin is an important archetype for G‐protein‐coupled receptors, which are membrane proteins implicated in cellular signal transduction. Herein, we…”
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Deuterium NMR Structure of Retinal in the Ground State of Rhodopsin by Salgado, Gilmar F. J, Struts, Andrey V, Tanaka, Katsunori, Fujioka, Naoko, Nakanishi, Koji, Brown, Michael F

“…The conformation of retinal bound to the G protein-coupled receptor rhodopsin is intimately linked to its photochemistry, which initiates the visual process…”
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Water is a powerful dynamic allosteric modulator in rhodopsin activation by Hewage, Kushani S.K., Fried, Steven D.E., Kadinappulige, Shalini D.S., Struts, Andrey V., Perera, Suchithranga M.D.C., Brown, Michael F.

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Packing and elasticity in membrane mechanical properties by Doole, Fathima T., Kit Chan, Chun, Sarkar, Daipayan, Nath, Ankan, Job, Constantin, Struts, Andrey V., Singharoy, Abhishek, Brown, Michael F.

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Influence of soft matter on rhodopsin activation by Kadinappulige, Shalini D.S., Hewage, Kushani S.K., Primack, Eric N., Struts, Andrey V., Brown, Michael F.

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Electronic structure calculations and deuterium NMR spectroscopy reveal retinal mobility in rhodopsin activation by Perera, Suchithranga M.D.C., Erly, Andrew, Makara, Anna, Nikolaev, Dmitrii M., Ryazantsev, Mikhail N., Struts, Andrey V., Brown, Michael F.

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Hydration-mediated G-protein-coupled receptor activation by Fried, Steven D E, Hewage, Kushani S K, Eitel, Anna R, Struts, Andrey V, Weerasinghe, Nipuna, Perera, Suchithranga M D C, Brown, Michael F

“…The Rhodopsin family of G-protein–coupled receptors (GPCRs) comprises the targets of nearly a third of all pharmaceuticals. Despite structural water present in…”
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Extent of Internal Hydration influence the Activation of GPCR Rhodopsin by Weerasinghe, Nipuna, Fried, Steven D. E., Struts, Andrey V., Perera, Suchithranga M. D. C., Brown, Michael F.

“…Rhodopsin is an archetypical GPCR responsible for dim‐light vision, which adopts a dynamic equilibrium between two metastable intermediates, metarhodopsin‐I…”
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Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin by Navidi, Mozhgan, Yadav, Shreya, Struts, Andrey V., Brown, Michael F., Nesnas, Nasri

“…[Display omitted] •Deuterium labeled 9Z retinoid synthesized in 6 steps.•2 Steps require no purification.•Efficient greener introduction of a deuterium label…”
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Synthesis of CD3-Labeled 11-cis-Retinals and Application to Solid-State Deuterium NMR Spectroscopy of Rhodopsin by Tanaka, Katsunori, Struts, Andrey V, Krane, Sonja, Fujioka, Naoko, Salgado, Gilmar F. J, Martínez-Mayorga, Karina, Brown, Michael F, Nakanishi, Koji

“…Efficient synthesis of 11-Z-retinals labeled with 2H at the C5, C9, or C13 methyl groups is described. The 2H-labeled retinals were used to regenerate the…”
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Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsins by Ryazantsev, Mikhail N., Nikolaev, Dmitrii M., Struts, Andrey V., Brown, Michael F.

“…Computational chemistry provides versatile methods for studying the properties and functioning of biological systems at different levels of precision and at…”
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For every retinylidene a force field: Using machine learning to improve molecular simulations of rhodopsins by Erly, Andrew M., Gerber, Benjamin I., Li, Renee J., Doole, Fathima T., Nikolaev, Dmitrii M., Ryazantsev, Mikhail N., Struts, Andrey V., Brown, Michael F.

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