Rational Design of Pectin-Chitosan Polyelectrolyte Nanoparticles for Enhanced Temozolomide Delivery in Brain Tumor Therapy

Rational Design of Pectin-Chitosan Polyelectrolyte Nanoparticles for Enhanced Temozolomide Delivery in Brain Tumor Therapy

Conventional chemotherapeutic approaches currently used for brain tumor treatment have low efficiency in targeted drug delivery and often have non-target toxicity. Development of stable and effective drug delivery vehicles for the most incurable diseases is one of the urgent biomedical challenges. W...

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Bibliographic Details
Published in:Biomedicines Vol. 12; no. 7; p. 1393
Main Authors: Silant'ev, Vladimir E, Belousov, Andrei S, Trukhin, Fedor O, Struppul, Nadezhda E, Shmelev, Mikhail E, Patlay, Aleksandra A, Shatilov, Roman A, Kumeiko, Vadim V
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 23-06-2024
Subjects:
biomaterials
Biomedical materials
Biopolymers
Brain cancer
Brain tumors
Cancer therapies
carbohydrates
Chemotherapy
Chitosan
Drug delivery
drug delivery systems
Drug development
Drugs
Extracellular matrix
Infrared spectroscopy
Mechanical properties
nanocarrier
Nanomaterials
Nanoparticles
Nanotechnology
Pectin
Polymers
Polysaccharides
Potassium
Rheology
Side effects
Signal transduction
Temozolomide
Toxicity
Tumors
viscoelastic properties
Zeta potential
United Kingdom > UK
United States > US
China
Germany
Russia
carbohydrates
polysaccharides
temozolomide
drug delivery systems
blood–brain barrier
brain tumors
nanocarrier
biomaterials
viscoelastic properties
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Summary:Conventional chemotherapeutic approaches currently used for brain tumor treatment have low efficiency in targeted drug delivery and often have non-target toxicity. Development of stable and effective drug delivery vehicles for the most incurable diseases is one of the urgent biomedical challenges. We have developed polymer nanoparticles (NPs) with improved temozolomide (TMZ) delivery for promising brain tumor therapy, performing a rational design of polyelectrolyte complexes of oppositely charged polysaccharides of cationic chitosan and anionic pectin. The NPs' diameter (30 to 330 nm) and zeta-potential (-29 to 73 mV) varied according to the initial mass ratios of the biopolymers. The evaluation of nanomechanical parameters of native NPs demonstrated changes in Young's modulus from 58 to 234 kPa and adhesion from -0.3 to -3.57 pN. Possible mechanisms of NPs' formation preliminary based on ionic interactions between ionogenic functional groups were proposed by IR spectroscopy and dynamic rheology. The study of the parameters and kinetics of TMZ sorption made it possible to identify compounds that most effectively immobilize and release the active substance in model liquids that simulate the internal environment of the body. A polyelectrolyte carrier based on an equal ratio of pectin-chitosan (0.1% by weight) was selected as the most effective for the delivery of TMZ among a series of obtained NPs, which indicates a promising approach to the treatment of brain tumors.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12071393