Search Results - "Strum, Susan L."

Discovery of Selective Small Molecule Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents by Leivers, Anna L., Tallant, Matthew, Shotwell, J. Brad, Dickerson, Scott, Leivers, Martin R., McDonald, Octerloney B., Gobel, Jeff, Creech, Katrina L., Strum, Susan L., Mathis, Amanda, Rogers, Sabrinia, Moore, Chris B., Botyanszki, Janos

“…Hepatitis C virus (HCV) assembles many host cellular proteins into unique membranous replication structures as a prerequisite for viral replication, and…”
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A biomarker of aging, p16, predicts peripheral neuropathy in women receiving adjuvant taxanes for breast cancer by Mitin, Natalia, Nyrop, Kirsten A., Strum, Susan L., Knecht, Anne, Carey, Lisa A., Reeder-Hayes, Katherine E., Claire Dees, E., Jolly, Trevor A., Kimmick, Gretchen G., Karuturi, Meghan S., Reinbolt, Raquel E., Speca, JoEllen C., O’Hare, Erin A., Muss, Hyman B.

“…Identifying patients at higher risk of chemotherapy-induced peripheral neuropathy (CIPN) is a major unmet need given its high incidence, persistence, and…”
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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity by RHODES, Nelson, HEERDING, Dirk A, KAHANA, Jason A, GESKE, Robert S, KIEYMENOVA, Elena V, CHOUDHRY, Anthony E, ZHIHONG LAI, LEBER, Jack D, MINTHORN, Elisabeth A, STRUM, Susan L, WOOD, Edgar R, HUANG, Pearl S, DUCKETT, Derek R, COPELAND, Robert A, KUMAR, Rakesh, EBERWEIN, Derek J, KNICK, Victoria B, LANSING, Timothy J, MCCONNELL, Randy T, GILMER, Tona M, ZHANG, Shu-Yun, ROBELL, Kimberly

“…Akt kinases 1, 2, and 3 are important regulators of cell survival and have been shown to be constitutively active in a variety of human tumors. GSK690693 is a…”
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Expression of p16 INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis by Diekman, Brian O, Sessions, Garrett A, Collins, John A, Knecht, Anne K, Strum, Susan L, Mitin, Natalia K, Carlson, Cathy S, Loeser, Richard F, Sharpless, Norman E

“…Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro-inflammatory…”
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Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis by Diekman, Brian O., Sessions, Garrett A., Collins, John A., Knecht, Anne K., Strum, Susan L., Mitin, Natalia K., Carlson, Cathy S., Loeser, Richard F., Sharpless, Norman E.

“…Summary Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing…”
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Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis by Diekman, Brian O, Sessions, Garrett A, Collins, John A, Knecht, Anne K, Strum, Susan L, Mitin, Natalia K, Carlson, Cathy S, Loeser, Richard F, Sharpless, Norman E

“…Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro‐inflammatory…”
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Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase by Heerding, Dirk A, Rhodes, Nelson, Leber, Jack D, Clark, Tammy J, Keenan, Richard M, Lafrance, Louis V, Li, Mei, Safonov, Igor G, Takata, Dennis T, Venslavsky, Joseph W, Yamashita, Dennis S, Choudhry, Anthony E, Copeland, Robert A, Lai, Zhihong, Schaber, Michael D, Tummino, Peter J, Strum, Susan L, Wood, Edgar R, Duckett, Derek R, Eberwein, Derek, Knick, Victoria B, Lansing, Timothy J, McConnell, Randy T, Zhang, ShuYun, Minthorn, Elisabeth A, Concha, Nestor O, Warren, Gregory L, Kumar, Rakesh

“…Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors…”
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2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity by Lin, Hong, Yamashita, Dennis S., Zeng, Jin, Xie, Ren, Wang, Wenyong, Nidarmarthy, Sirishkumar, Luengo, Juan I., Rhodes, Nelson, Knick, Victoria B., Choudhry, Anthony E., Lai, Zhihong, Minthorn, Elisabeth A., Strum, Susan L., Wood, Edgar R., Elkins, Patricia A., Concha, Nestor O., Heerding, Dirk A.

“…2,3,5-Trisubstituted pyridines have been designed as potent AKT inhibitors that are selective against ROCK1 based on the comparison between AKT and ROCK1…”
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Crk is required for apoptosis in Xenopus egg extracts by Evans, Erica K., Lu, Wange, Strum, Susan L., Mayer, Bruce J., Kornbluth, Sally

“…Apoptosis is essential for the development and homeostasis of multicellular organisms. Recently, a cell‐free extract prepared from Xenopus eggs was shown to…”
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Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3 S )-3-piperidinylmethyl]oxy}-1 H -imidazo[4,5- c ]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase by Heerding, Dirk A., Rhodes, Nelson, Leber, Jack D., Clark, Tammy J., Keenan, Richard M., Lafrance, Louis V., Li, Mei, Safonov, Igor G., Takata, Dennis T., Venslavsky, Joseph W., Yamashita, Dennis S., Choudhry, Anthony E., Copeland, Robert A., Lai, Zhihong, Schaber, Michael D., Tummino, Peter J., Strum, Susan L., Wood, Edgar R., Duckett, Derek R., Eberwein, Derek, Knick, Victoria B., Lansing, Timothy J., McConnell, Randy T., Zhang, ShuYun, Minthorn, Elisabeth A., Concha, Nestor O., Warren, Gregory L., Kumar, Rakesh

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Identification of 4-2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-([(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase by HEERDING, Dirk A, RHODES, Nelson, YAMASHITA, Dennis S, CHOUDHRY, Anthony E, COPELAND, Robert A, ZHIHONG LAI, SCHABER, Michael D, TUMMINO, Peter J, STRUM, Susan L, WOOD, Edgar R, DUCKETT, Derek R, EBERWEIN, Derek, LEBER, Jack D, KNICK, Victoria B, LANSING, Timothy J, MCCONNELL, Randy T, SHUYUN ZHANG, MINTHORN, Elisabeth A, CONCHA, Nestor O, WARREN, Gregory L, KUMAR, Rakesh, CLARK, Tammy J, KEENAN, Richard M, LAFRANCE, Louis V, MEI LI, SAFONOV, Igor G, TAKATA, Dennis T, VENSLAVSKY, Joseph W

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Reaper-induced apoptosis in a vertebrate system by Evans, Erica K., Kuwana, Tomomi, Strum, Susan L., Smith, Jesse J., Newmeyer, Donald D., Kornbluth, Sally

“…The reaper protein of Drosophila melanogaster has been shown to be a central regulator of apoptosis in that organism. However, it has not been shown to…”
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