Search Results - "Strugnell, Richard A."

When secretion turns into excretion - the different roles of IgA by Strugnell, Richard A

“…IgA deficiency is the commonest immunodeficiency affecting up to 1 in 700 individuals. The effects of IgA deficiency are difficult to see in many individuals,…”
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Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients by Gorrie, Claire L., Mirčeta, Mirjana, Wick, Ryan R., Edwards, David J., Thomson, Nicholas R., Strugnell, Richard A., Pratt, Nigel F., Garlick, Jill S., Watson, Kerri M., Pilcher, David V., McGloughlin, Steve A., Spelman, Denis W., Jenney, Adam W. J., Holt, Kathryn E.

“…Background. Klebsiella pneumoniae is an opportunistic pathogen and leading cause of hospital-associated infections. Intensive care unit (ICU) patients are…”
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Bastion6: a bioinformatics approach for accurate prediction of type VI secreted effectors by Wang, Jiawei, Yang, Bingjiao, Leier, André, Marquez-Lago, Tatiana T, Hayashida, Morihiro, Rocker, Andrea, Zhang, Yanju, Akutsu, Tatsuya, Chou, Kuo-Chen, Strugnell, Richard A, Song, Jiangning, Lithgow, Trevor

“…Abstract Motivation Many Gram-negative bacteria use type VI secretion systems (T6SS) to export effector proteins into adjacent target cells. These secreted…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae by Nang, Sue C, Morris, Faye C, McDonald, Michael J, Han, Mei-Ling, Wang, Jiping, Strugnell, Richard A, Velkov, Tony, Li, Jian

“…Abstract Objectives The discovery of mobile colistin resistance mcr-1, a plasmid-borne polymyxin resistance gene, highlights the potential for widespread…”
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The role of secretory antibodies in infection immunity by Strugnell, Richard A, Wijburg, Odilia L. C

“…Key Points Secretory antibodies (SIgs) have long been recognized as immune effectors that protect mucosal epithelia from infection by pathogens. Recent studies…”
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The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1 by McWilliam, Hamish E G, Eckle, Sidonia B G, Theodossis, Alex, Liu, Ligong, Chen, Zhenjun, Wubben, Jacinta M, Fairlie, David P, Strugnell, Richard A, Mintern, Justine D, McCluskey, James, Rossjohn, Jamie, Villadangos, Jose A

“…MR1 molecules present bacterial metabolites to MAIT innate lymphocytes, but the processing and presentation pathway of these ligands are unclear. McCluskey,…”
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Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen by Gorrie, Claire L., Mirčeta, Mirjana, Wick, Ryan R., Judd, Louise M., Lam, Margaret M. C., Gomi, Ryota, Abbott, Iain J., Thomson, Nicholas R., Strugnell, Richard A., Pratt, Nigel F., Garlick, Jill S., Watson, Kerrie M., Hunter, Peter C., Pilcher, David V., McGloughlin, Steve A., Spelman, Denis W., Wyres, Kelly L., Jenney, Adam W. J., Holt, Kathryn E.

“…Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections, which are increasingly complicated by the presence of…”
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Antimicrobial-Resistant Klebsiella pneumoniae Carriage and Infection in Specialized Geriatric Care Wards Linked to Acquisition in the Referring Hospital by Gorrie, Claire L, Mirceta, Mirjana, Wick, Ryan R, Judd, Louise M, Wyres, Kelly L, Thomson, Nicholas R, Strugnell, Richard A, Pratt, Nigel F, Garlick, Jill S, Watson, Kerrie M, Hunter, Peter C, McGloughlin, Steve A, Spelman, Denis W, Jenney, Adam W J, Holt, Kathryn E

“…Patients' own gut microbiota were the major source of Klebsiella pneumoniae, but extended-spectrum β-lactamase strains were acquired in the referring hospital…”
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Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae by Rocker, Andrea, Lacey, Jake A, Belousoff, Matthew J, Wilksch, Jonathan J, Strugnell, Richard A, Davies, Mark R, Lithgow, Trevor

“…In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of antimicrobial treatment…”
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Cellular requirements for systemic control of Salmonella enterica serovar Typhimurium infections in mice by Kupz, Andreas, Bedoui, Sammy, Strugnell, Richard A

“…The rational design of vaccines requires an understanding of the contributions of individual immune cell subsets to immunity. With this understanding, targeted…”
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Atomic force microscopy of bacteria reveals the mechanobiology of pore forming peptide action by Mularski, Anna, Wilksch, Jonathan J., Hanssen, Eric, Strugnell, Richard A., Separovic, Frances

“…Time-resolved AFM images revealed that the antimicrobial peptide (AMP) caerin 1.1 caused localised defects in the cell walls of lysed Klebsiella pneumoniae…”
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Distribution and diversity of classical deacylases in bacteria by Graf, Leonie G., Moreno-Yruela, Carlos, Qin, Chuan, Schulze, Sabrina, Palm, Gottfried J., Schmöker, Ole, Wang, Nancy, Hocking, Dianna M., Jebeli, Leila, Girbardt, Britta, Berndt, Leona, Dörre, Babett, Weis, Daniel M., Janetzky, Markus, Albrecht, Dirk, Zühlke, Daniela, Sievers, Susanne, Strugnell, Richard A., Olsen, Christian A., Hofmann, Kay, Lammers, Michael

“…Classical Zn 2+ -dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures,…”
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In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes by Kupz, Andreas, Curtiss, 3rd, Roy, Bedoui, Sammy, Strugnell, Richard A

“…Natural killer (NK) cells are a critical part of the innate immune defense against viral infections and for the control of tumors. Much less is known about how…”
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Discovery of an archetypal protein transport system in bacterial outer membranes by Selkrig, Joel, Mosbahi, Khedidja, Webb, Chaille T, Belousoff, Matthew J, Perry, Andrew J, Wells, Timothy J, Morris, Faye, Leyton, Denisse L, Totsika, Makrina, Phan, Minh-Duy, Celik, Nermin, Kelly, Michelle, Oates, Clare, Hartland, Elizabeth L, Robins-Browne, Roy M, Ramarathinam, Sri Harsha, Purcell, Anthony W, Schembri, Mark A, Strugnell, Richard A, Henderson, Ian R, Walker, Daniel, Lithgow, Trevor

“…Bacterial secretion systems are key to pathogenesis, as they secrete the many virulence factors needed for host colonization. Bioinformatic and functional…”
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The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane by Gunasinghe, Sachith D., Shiota, Takuya, Stubenrauch, Christopher J., Schulze, Keith E., Webb, Chaille T., Fulcher, Alex J., Dunstan, Rhys A., Hay, Iain D., Naderer, Thomas, Whelan, Donna R., Bell, Toby D.M., Elgass, Kirstin D., Strugnell, Richard A., Lithgow, Trevor

“…The β-barrel assembly machinery (BAM) complex is essential for localization of surface proteins on bacterial cells, but the mechanism by which it functions is…”
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Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan by Ejaz, Hasan, Wang, Nancy, Wilksch, Jonathan J, Page, Andrew J, Cao, Hanwei, Gujaran, Shruti, Keane, Jacqueline A, Lithgow, Trevor, Ul-Haq, Ikram, Dougan, Gordon, Strugnell, Richard A, Heinz, Eva

“…Klebsiella pneumoniae shows increasing emergence of multidrug-resistant lineages, including strains resistant to all available antimicrobial drugs. We…”
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T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming by Greyer, Marie, Whitney, Paul G., Stock, Angus T., Davey, Gayle M., Tebartz, Christina, Bachem, Annabell, Mintern, Justine D., Strugnell, Richard A., Turner, Stephen J., Gebhardt, Thomas, O’Keeffe, Meredith, Heath, William R., Bedoui, Sammy

“…DCs often require stimulation from CD4+ T cells to propagate CD8+ T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why…”
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Extensively Drug-Resistant Klebsiella pneumoniae Causing Nosocomial Bloodstream Infections in China: Molecular Investigation of Antibiotic Resistance Determinants, Informing Therapy, and Clinical Outcomes by Bi, Wenzi, Liu, Haiyang, Dunstan, Rhys A, Li, Bin, Torres, Von Vergel L, Cao, Jianming, Chen, Lijiang, Wilksch, Jonathan J, Strugnell, Richard A, Lithgow, Trevor, Zhou, Tieli

“…The rise in diversity of antimicrobial resistance phenotypes seen in is becoming a serious antibiotic management problem. We sought to investigate the…”
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Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria by Mularski, Anna, Wilksch, Jonathan J, Wang, Huabin, Hossain, Mohammed Akhter, Wade, John D, Separovic, Frances, Strugnell, Richard A, Gee, Michelle L

“…Increasing rates of antimicrobial-resistant medically important bacteria require the development of new, effective therapeutics, of which antimicrobial…”
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