Search Results - "Struble, Lucas"

A glimpse into the hidden world of the flexible C-terminal protein binding domains of human RAD52 by Struble, Lucas R., Lovelace, Jeffrey J., Borgstahl, Gloria E.O.

“…[Display omitted] •RAD52, a drug target in HR-deficient cancers, has no known full-length structure.•RAD52 C-terminus binds RPA, which is important for all DNA…”
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Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition by Azadmanesh, Jahaun, Slobodnik, Katelyn, Struble, Lucas R., Lutz, William E., Coates, Leighton, Weiss, Kevin L., Myles, Dean A. A., Kroll, Thomas, Borgstahl, Gloria E. O.

“…Human manganese superoxide dismutase (MnSOD) is a crucial oxidoreductase that maintains the vitality of mitochondria by converting superoxide (O 2 ●− ) to…”
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CyDisCo production of functional recombinant SARS‐CoV‐2 spike receptor binding domain by Prahlad, Janani, Struble, Lucas R., Lutz, William E., Wallin, Savanna A., Khurana, Surender, Schnaubelt, Andy, Broadhurst, Mara J., Bayles, Kenneth W., Borgstahl, Gloria E. O.

“…The COVID‐19 pandemic caused by SARS‐CoV‐2 has applied significant pressure on overtaxed healthcare around the world, underscoring the urgent need for rapid…”
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Structural Basis for the Interaction Between Yeast Chromatin Assembly Factor 1 and Proliferating Cell Nuclear Antigen by Orndorff, Keely S., Veltri, Evan J., Hoitsma, Nicole M., Williams, Ivy L., Hall, Ian, Jaworski, Grace E., Majeres, Grace E., Kallepalli, Samaya, Vito, Abigayle F., Struble, Lucas R., Borgstahl, Gloria E.O., Dieckman, Lynne M.

“…[Display omitted] •How does PCNA choose who to bind (via PIP motifs) at the replication fork?•Development of a novel method for determining structures of…”
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Insect cell expression and purification of recombinant SARS‐COV‐2 spike proteins that demonstrate ACE2 binding by Struble, Lucas R., Smith, Audrey L., Lutz, William E., Grubbs, Gabrielle, Sagar, Satish, Bayles, Kenneth W., Radhakrishnan, Prakash, Khurana, Surender, El‐Gamal, Dalia, Borgstahl, Gloria E. O.

“…The COVID‐19 pandemic caused by SARS‐CoV‐2 infection has led to socio‐economic shutdowns and the loss of over 5 million lives worldwide. There is a need for…”
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Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction by Al-Mugotir, Mona, Lovelace, Jeffrey J, George, Joseph, Bessho, Mika, Pal, Dhananjaya, Struble, Lucas, Kolar, Carol, Rana, Sandeep, Natarajan, Amarnath, Bessho, Tadayoshi, Borgstahl, Gloria E O

“…Synthetic lethality is a successful strategy employed to develop selective chemotherapeutics against cancer cells. Inactivation of RAD52 is synthetically…”
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A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge by Pattnaik, Aryamav, Sahoo, Bikash R, Struble, Lucas R, Borgstahl, Gloria E O, Zhou, You, Franco, Rodrigo, Barletta, Raul G, Osorio, Fernando A, Petro, Thomas M, Pattnaik, Asit K

“…The severe consequences of the Zika virus (ZIKV) infections resulting in congenital Zika syndrome in infants and the autoimmune Guillain-Barre syndrome in…”
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Bromelain inhibits SARS‐CoV‐2 infection via targeting ACE‐2, TMPRSS2, and spike protein by Sagar, Satish, Rathinavel, Ashok Kumar, Lutz, William E., Struble, Lucas R., Khurana, Surender, Schnaubelt, Andy T., Mishra, Nitish Kumar, Guda, Chittibabu, Palermo, Nicholas Y., Broadhurst, Mara J., Hoffmann, Tobias, Bayles, Kenneth W., Reid, St. Patrick M., Borgstahl, Gloria E. O., Radhakrishnan, Prakash

“…SARS-CoV-2 infects angiotensin-converting enzyme 2 (ACE-2) expressing lung, heart, kidney, intestine, gall bladder, and testicular tissues of patients, leading…”
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The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core by Simone, Peter D., Struble, Lucas R., Kellezi, Admir, Brown, Carrie A., Grabow, Corinn E., Khutsishvili, Irine, Marky, Luis A., Pavlov, Youri I., Borgstahl, Gloria E.O.

“…Inosine triphosphate pyrophosphatase (ITPA), a key enzyme involved in maintaining the purity of cellular nucleoside triphosphate pools, specifically recognizes…”
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BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis by Huang, Kai, O’Neill, Katelyn L., Li, Jian, Zhou, Wei, Han, Na, Pang, Xiaming, Wu, Wei, Struble, Lucas, Borgstahl, Gloria, Liu, Zhaorui, Zhang, Liqiang, Luo, Xu

“…It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins (BID, BIM, etc.) directly engage and allosterically…”
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Optimizing the conditions for GGDPS crystal growth by Pham, Andrew, Struble, Lucas, Holstein, Sarah, Borgstahl, Gloria

“…Abstract only…”
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The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis by Azadmanesh, Jahaun, Seleem, Mohamed A., Struble, Lucas, Wood, Nicholas A., Fisher, Derek J., Lovelace, Jeffrey J., Artigues, Antonio, Fenton, Aron W., Borgstahl, Gloria E.O., Ouellette, Scot P., Conda-Sheridan, Martin

“…Chlamydia trachomatis (ct) is the most reported bacterial sexually transmitted infection worldwide and the leading cause of preventable blindness. Caseinolytic…”
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