Search Results - "Struble, Geoffrey T"

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 by Qi, Jenson, Lang, Wensheng, Geisler, John G., Wang, Ping, Petrounia, Ioanna, Mai, Selyna, Smith, Charles, Askari, Hossein, Struble, Geoffrey T., Williams, Robyn, Bhanot, Sanjay, Monia, Brett P., Bayoumy, Shariff, Grant, Eugene, Caldwell, Gary W., Todd, Matthew J., Liang, Yin, Gaul, Micheal D., Demarest, Keith T., Connelly, Margery A.

“…Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. There are two isoforms, DGAT1 and DGAT2, with distinct protein…”
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Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors by Schubert, Carsten, Schalk-Hihi, Céline, Struble, Geoffrey T., Ma, Hong-Chang, Petrounia, Ioanna P., Brandt, Benjamin, Deckman, Ingrid C., Patch, Raymond J., Player, Mark R., Spurlino, John C., Springer, Barry A.

“…The cFMS proto-oncogene encodes for the colony-stimulating factor-1 receptor, a receptor-tyrosine kinase responsible for the differentiation and maturation of…”
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Enhancing recombinant protein quality and yield by protein stability profiling by Mezzasalma, Tara M, Kranz, James K, Chan, Winnie, Struble, Geoffrey T, Schalk-Hihi, Céline, Deckman, Ingrid C, Springer, Barry A, Todd, Matthew J

“…The reliable production of large amounts of stable, high-quality proteins is a major challenge facing pharmaceutical protein biochemists, necessary for…”
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Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies by Schalk-Hihi, Céline, Ma, Hong-Chang, Struble, Geoffrey T., Bayoumy, Shariff, Williams, Robyn, Devine, Eric, Petrounia, Ioanna P., Mezzasalma, Tara, Zeng, Lee, Schubert, Carsten, Grasberger, Bruce, Springer, Barry A., Deckman, Ingrid C.

“…A parallel approach to designing crystallization constructs for the c-FMS kinase domain was implemented, resulting in proteins suitable for structural studies…”
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4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors by Xu, Guozhang, Abad, Marta C., Connolly, Peter J., Neeper, Michael P., Struble, Geoffrey T., Springer, Barry A., Emanuel, Stuart L., Pandey, Niranjan, Gruninger, Robert H., Adams, Mary, Moreno-Mazza, Sandra, Fuentes-Pesquera, Angel R., Middleton, Steven A.

“…Members of a novel class of 4-amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones were identified as potent dual ErbB-2/EGFR kinase inhibitors using…”
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Electron Density Guided Fragment-Based Lead Discovery of Ketohexokinase Inhibitors by Gibbs, Alan C, Abad, Marta C, Zhang, Xuqing, Tounge, Brett A, Lewandowski, Francis A, Struble, Geoffrey T, Sun, Weimei, Sui, Zhihua, Kuo, Lawrence C

“…A fragment-based drug design paradigm has been successfully applied in the discovery of lead series of ketohexokinase inhibitors. The paradigm consists of…”
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Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases by Xu, Guozhang, Searle, Lily Lee, Hughes, Terry V., Beck, Amanda K., Connolly, Peter J., Abad, Marta C., Neeper, Michael P., Struble, Geoffrey T., Springer, Barry A., Emanuel, Stuart L., Gruninger, Robert H., Pandey, Niranjan, Adams, Mary, Moreno-Mazza, Sandra, Fuentes-Pesquera, Angel R., Middleton, Steven A., Greenberger, Lee M.

“…We herein disclose a novel series of 4-aminopyrimidine-5-carbaldehyde oximes that are potent and selective inhibitors of both EGFR and ErbB-2 tyrosine kinases,…”
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