Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Essential oils and aromatic extracts (oleoresins, absolutes, concretes, resinoids) are often used as food flavorings and constituents of fragrance compositions. The flavor and fragrance industry observed significant growth in the sales of some natural materials during the COVID-19 outbreak. Some com...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 14230
Main Authors:	Strub, Daniel Jan, Talma, Michał, Strub, Maria, Rut, Wioletta, Zmudzinski, Mikolaj, Brud, Władysław, Neyts, Johan, Vangeel, Laura, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Olsen, Shaun K., Hilgenfeld, Rolf, Jochmans, Dirk, Drąg, Marcin
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20-08-2022 Nature Publishing Group Nature Portfolio
Subjects:	631/326/596/4130 631/45/468 Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Binding sites Biochemistry Biology Coronaviridae Coronaviruses Cosmetics industry COVID-19 Drug therapy Essential oils Flavorings Humanities and Social Sciences Humans Inhalation Ligands Marketing Middle East respiratory syndrome multidisciplinary Oils & fats Oils, Volatile - pharmacology Oleoresins Papain Protease Inhibitors Proteinase inhibitors R&D Research & development SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2
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Summary:	Essential oils and aromatic extracts (oleoresins, absolutes, concretes, resinoids) are often used as food flavorings and constituents of fragrance compositions. The flavor and fragrance industry observed significant growth in the sales of some natural materials during the COVID-19 outbreak. Some companies worldwide are making false claims regarding the effectiveness of their essential oils or blends (or indirectly point toward this conclusion) against coronaviruses, even though the available data on the activity of plant materials against highly pathogenic human coronaviruses are very scarce. Our exploratory study aimed to develop pioneering knowledge and provide the first experimental results on the inhibitory properties of hundreds of flavor and fragrance materials against SARS-CoV-2 main and papain-like proteases and the antiviral potential of the most active protease inhibitors. As essential oils are volatile products, they could provide an interesting therapeutic strategy for subsidiary inhalation in the long term.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-18676-w