Search Results - "Strout, V."

Phase I randomized study of KHK4083, an anti‐OX40 monoclonal antibody, in patients with mild to moderate plaque psoriasis by Papp, K.A., Gooderham, M.J., Girard, G., Raman, M., Strout, V.

“…Background OX40 (CD134) is expressed in lesional but not healthy skin of patients with psoriasis. KHK4083 is a fully human monoclonal antibody against OX40…”
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Phase I randomized study of KHK 4083, an anti‐ OX 40 monoclonal antibody, in patients with mild to moderate plaque psoriasis by Papp, K.A., Gooderham, M.J., Girard, G., Raman, M., Strout, V.

“…Abstract Background OX 40 ( CD 134) is expressed in lesional but not healthy skin of patients with psoriasis. KHK 4083 is a fully human monoclonal antibody…”
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Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting by Berger, Joel, Biswas, Chhabi, Vicario, Pasquale P, Strout, H. Vincent, Saperstein, Richard, Pilch, Paul F

“…Cellular resistance to insulin caused by a reduction in insulin-mediated glucose uptake can be produced in rats by chemically inducing diabetes with…”
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The insulin-mimetic effect of vanadate is not correlated with insulin receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo by Strout, H V, Vicario, P P, Saperstein, R, Slater, E E

“…The in vivo administration of sodium orthovanadate stimulated the incorporation of [14C]glucose into [14C] glycogen, in a dose- and time-dependent manner, in…”
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Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin-responsive glucose transporter in skeletal muscle by Strout, H V, Vicario, P P, Biswas, C, Saperstein, R, Brady, E J, Pilch, P F, Berger, J

“…Streptozotocin-treated rats were diabetic, as assessed by blood glucose and plasma insulin values, while vanadate treatment restored blood glucose values to…”
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Pure human renin. Identification and characterization and of two major molecular weight forms by E E Slater, H V Strout, Jr

“…Human renal renin was purified from normal kidney by either of two protocols which combined sequential DEAE-cellulose chromatography, pepstatin affinity…”
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Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells by Saperstein, Richard, Vicario, Pasquale P, Strout, H. Vincent, Brady, Edward, Slater, Eve E, Greenlee, William J, Ondeyka, Debra L, Patchett, Arthur A, Hangauer, David G

“…An inhibitor of the insulin receptor tyrosine kinase (IRTK), (hydroxy-2-naphthalenyl-methyl) phosphonic acid, was designed and synthesized and was shown to be…”
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Activation by protein synthesis inhibitors of glucose transport into L6 muscle cells by Hayes, N, Biswas, C, Strout, H V, Berger, J

“…The effects of protein synthesis inhibitors on glucose transport into L6 myotubes was examined. Similar to the acute effects of insulin, short-term treatment…”
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Synthetic segments of the mammalian beta AR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C by Blake, A D, Mumford, R A, Strout, H V, Slater, E E, Strader, C D

“…Desensitization of the beta-adrenergic receptor has been correlated in some cell systems with receptor phosphorylation. Various kinases have been implicated in…”
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A protein phosphotyrosine phosphatase distinct from alkaline phosphatase with activity against the insulin receptor by Strout, H V, Vicario, P P, Saperstein, R, Slater, E E

“…Rat liver plasma membranes were found to have a relatively high ratio of acid to alkaline phosphatase activity when compared to rabbit liver and human…”
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The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes by Allard, W J, Vicario, P P, Saperstein, R, Slater, E E, Strout, H V

“…Adenylate cyclase activity was examined as a measure of inhibitory guanine nucleotide binding protein (Gi) function in liver plasma membranes from rats made…”
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Thiourea and cyanamide as inhibitors of thyroid peroxidase: the role of iodide by Davidson, B, Soodak, M, Strout, H V, Neary, J T, Nakamura, C, Maloof, F

“…Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination. Unlike the…”
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Solubilization of thyroid peroxidase by nonionic detergents by Neary, J T, Davidson, B, Armstrong, A, Strout, H V, Maloof, F

“…We have examined the ability of nonionic detergents to solubilize thyroid peroxidase from a porcine thyroid particulate fraction, as measured by the release of…”
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Interaction of thyroid peroxidase with concanavalin A covalently coupled to agarose by Neary, J.T, Koepsell, D, Davidson, B, Armstrong, A, Strout, H.V, Soodak, M, Maloof, F

“…We have investigated the interaction between concanavalin A-agarose (Con A-agarose) and thyroid peroxidase, an integral membrane protein found in the 105,000 X…”
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Evidence for a thyroid peroxidase associated "active iodine" species by Davidson, B, Neary, J T, Strout, H V, Maloof, F, Soodak, M

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Protomer stability and sclerotization in vitro by Strout, H V, Lipke, H

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The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazole, thiouracil, and propylthiouracil in vitro and its relationship to in vivo findings by Davidson, B, Soodak, M, Neary, J T, Strout, H V, Kieffer, J D, Mover, H, Maloof, F

“…A reinvestigation of the mechanism of action of methylmercaptoimidazole, propylthiouracil, and thiouracil on thyroid peroxidase (TPO) was undertaken. A…”
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