Search Results - "Strothman, Claire"
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Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
Published in Nature communications (09-07-2018)“…Higher-order structures of the microtubule (MT) cytoskeleton are comprised of two architectures: bundles and asters. Although both architectures are critical…”
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Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging
Published in Neurobiology of disease (01-07-2019)“…The amyloid precursor protein (APP) has been extensively studied because of its association with Alzheimer's disease (AD). However, APP distribution across…”
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Ammonium chloride alters neuronal excitability and synaptic vesicle release
Published in Scientific reports (11-07-2017)“…Genetically encoded pH-sensors are widely used in studying cell membrane trafficking and membrane protein turnover because they render…”
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Impact of the ‘tubulin economy’ on the formation and function of the microtubule cytoskeleton
Published in Current opinion in cell biology (01-02-2021)“…The microtubule cytoskeleton is assembled from a finite pool of α,β-tubulin, the size of which is controlled by an autoregulation mechanism. Cells also tightly…”
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Microtubule minus-end stability is dictated by the tubulin off-rate
Published in The Journal of cell biology (02-09-2019)“…Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends…”
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