Search Results - "Strother, Dale E."

Acrylonitrile's genotoxicity profile: mutagenicity in search of an underlying molecular mechanism by Albertini, Richard J., Kirman, Christopher R., Strother, Dale E.

“…Acrylonitrile (ACN) is a known rodent and possible human carcinogen. There have also been concerns as to it causing adverse reproductive health effects…”
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Weight-of-the-evidence review of acrylonitrile reproductive and developmental toxicity studies by Neal, Barbara H., Collins, James J., Strother, Dale E., Lamb, James C.

“…Risk assessment of acrylonitrile (AN) toxicity to humans has focused on potential carcinogenicity and acute toxicity. Epidemiological studies from China…”
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Physiologically Based Pharmacokinetic Model Parameter Estimation and Sensitivity and Variability Analyses for Acrylonitrile Disposition in Humans by Sweeney, Lisa M., Gargas, Michael L., Strother, Dale E., Kedderis, Gregory L.

“…A physiologically based pharmacokinetic (PBPK) model of acrylonitrile (ACN) and cyanoethylene oxide (CEO) disposition in humans was developed and is based on…”
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Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water by Tyla, Rochelle W, Friedman, Marvin A, Losco, Patricia E, Fisher, Louann C, Johnson, Keith A, Strother, Dale E, Wolf, Claude H

“…Fischer 344 (F344) F 0 weanling rats, 30/sex/group, were exposed to acrylamide in drinking water at 0.0, 0.5, 2.0, or 5.0 mg/kg/day for 10 weeks and then…”
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Improving Cancer Dose-Response Characterization by Using Physiologically Based Pharmacokinetic Modeling: An Analysis of Pooled Data for Acrylonitrile-Induced Brain Tumors to Assess Cancer Potency in the Rat by Kirman, Christopher R., Hays, Sean M., Kedderis, Gregory L., Gargas, Michael L., Strother, Dale E.

“…Historically, U.S. regulators have derived cancer slope factors by using applied dose and tumor response data from a single key bioassay or by averaging the…”
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Isopropanol: acute vapor inhalation neurotoxicity study in rats by Gill, M W, Burleigh-Flayer, H D, Strother, D E, Masten, L W, McKee, R H, Tyler, T R, Gardiner, T H

“…Five groups of 25 Fischer 344 rats of each sex were exposed for 6 h to isopropanol vapor at 0, 500, 1500, 5000 or 10,000 ppm. Behavioral observations for 10…”
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CNS tumors and exposure to acrylonitrile: inconsistency between experimental and epidemiology studies by Collins, J J, Strother, D E

“…Acrylonitrile is a potent CNS tumorigen in rats leading to concern that it may be a tumorigen in humans. There have been 12 epidemiology studies of 37,352…”
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Isopropanol 13-week vapor inhalation study in rats and mice with neurotoxicity evaluation in rats by Burleigh-Flayer, H D, Gill, M W, Strother, D E, Masten, L W, McKee, R H, Tyler, T R, Gardiner, T

“…This study was conducted to evaluate the possible subchronic toxicity as well as neurobehavioral effects of isopropanol, a widely used industrial and…”
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A 90-day inhalation toxicity study of raw shale oil in Fischer 344 rats by Gordon, T, Strother, D E, Cramer, D V, Goode, J W

“…The potential health effects of a raw shale oil were evaluated in a 90-day inhalation study in Fischer 344 rats. Groups of 15 male and 15 female rats were…”
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