Search Results - "Stropova, D"

Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363 by Navratilova, Edita, Eaton, Miriam C., Stropova, Dagmar, Varga, Eva V., Vanderah, Todd W., Roeske, William R., Yamamura, Henry I.

“…After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and…”
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The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists by Varga, E V, Li, X, Stropova, D, Zalewska, T, Landsman, R S, Knapp, R J, Malatynska, E, Kawai, K, Mizusura, A, Nagase, H, Calderon, S N, Rice, K, Hruby, V J, Roeske, W R, Yamamura, H I

“…In the present study, we replaced the third extracellular loop of the human delta-opioid receptor with that of the human mu-opioid receptor. A modified…”
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The efficacy of δ-opioid receptor-selective drugs by Burkey, T.H., Ehlert, F.J., Hosohata, Y., Quock, R.M., Cowell, S., Hosohata, K., Varga, E., Stropova, D., Li, X., Slate, C., Nagase, H., Porreca, F., Hruby, V.J., Roeske, W.R., Yamamura, H.I.

“…δ-Opioid receptor-selective drugs may provide an alternative to μ-opioid-selective drugs currently used for the relief of pain. To develop improved δ-opioid…”
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Improved bioavailability to the brain of glycosylated Met-enkephalin analogs by Egleton, Richard D, Mitchell, Scott A, Huber, Jason D, Janders, Jaqueline, Stropova, Dagmar, Polt, Robin, Yamamura, Henry I, Hruby, Victor J, Davis, Thomas P

“…The blood–brain barrier prevents the entry of many potentially therapeutic peptide drugs to the brain. Glycosylation has shown potential as a methodology for…”
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Agonist-specific regulation of the δ-opioid receptor by Varga, Eva V., Navratilova, Edita, Stropova, Dagmar, Jambrosic, Janelle, Roeske, William R., Yamamura, Henry I.

“…Delta opioid receptor (DOR) agonists are attractive potential analgesics, since these compounds exhibit strong antinociceptive activity with relatively few…”
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Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment by Varga, Eva V, Rubenzik, Marc K, Stropova, Dagmar, Sugiyama, Masano, Grife, Vanessa, Hruby, Victor J, Rice, Kenner C, Roeske, William R, Yamamura, Henry I

“…Adenylyl cyclase (AC) superactivation is thought to play an important role in opioid tolerance, dependence, and withdrawal. In the present study, we…”
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Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment by Varga, Eva V, Yamamura, Henry I, Rubenzik, Marc K, Stropova, Dagmar, Navratilova, Edita, Roeske, William R

“…Opioid receptor agonists mediate their analgesic effects by interacting with Gi/o protein-coupled opioid receptors. Acute treatment with opioid agonists is…”
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Involvement of Raf-1 in chronic δ-opioid receptor agonist-mediated adenylyl cyclase superactivation by Varga, Eva V, Rubenzik, Marc, Grife, Vanessa, Sugiyama, Masano, Stropova, Dagmar, Roeske, William R, Yamamura, Henry I

“…Chronic δ-opioid receptor agonist treatment of Chinese hamster ovary (CHO) cells stably expressing the human δ-opioid receptor (hDOR/CHO) leads to increased…”
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Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation by Rubenzik, M, Varga, E, Stropova, D, Roeske, W R, Yamamura, H I

“…To investigate the role of G-protein beta gamma subunits in delta-opioid signal transduction, we have transfected Chinese hamster ovary (CHO) cells stably…”
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De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor by Liao, Subo, Alfaro-Lopez, Josue, Shenderovich, Mark D, Hosohata, Keiko, Lin, Jun, Li, Xiaoping, Stropova, Dagmar, Davis, Peg, Jernigan, Kevin A, Porreca, Frank, Yamamura, Henry I, Hruby, Victor J

“…On the basis of the structure−activity relationships of δ-opioid-selective peptide ligands and on a model of the proposed bioactive conformation for a potent…”
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Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin by Lipkowski, Andrzej W., Misicka, Aleksandra, Davis, Peg, Stropova, Dagmar, Janders, Jacqueline, Lachwa, Magdalena, Porreca, Frank, Yamamura, Henry I., Hruby, Victor J.

“…The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal…”
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Mutation S363A in the human δ-opioid receptor selectively reduces down-regulation by a peptide agonist by Navratilova, Edita, Varga, Eva V., Stropova, Dagmar, Jambrosic, Janelle C., Roeske, William R., Yamamura, Henry I.

“…Chemically distinct opioid agonists have different abilities to down-regulate opioid receptors. The present study investigated the role of Ser 363 in human…”
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Opiate Aromatic Pharmacophore Structure−Activity Relationships in CTAP Analogues Determined by Topographical Bias, Two-Dimensional NMR, and Biological Activity Assays by Bonner, G. Gregg, Davis, Peg, Stropova, Dagmar, Edsall, Sidney, Yamamura, Henry I, Porreca, Frank, Hruby, Victor J

“…Topographically constrained analogues of the highly μ-opioid-receptor-selective antagonist CTAP (H-d-Phe-c[Cys-Tyr-d-Trp-Arg-Thr-Pen]-Thr-NH2, 1) were prepared…”
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Identification of adenylyl cyclase isoenzymes in CHO and B82 cells by Varga, Eva V, Stropova, Dagmar, Rubenzik, Marc, Wang, Man, Landsman, Robert S, Roeske, William R, Yamamura, Henry I

“…The identification of adenylyl cyclase isoenzymes in mammalian host cells is important for the interpretation of data obtained from cell lines heterologously…”
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Cyclic Enkephalin Analogues with Exceptional Potency and Selectivity for δ-Opioid Receptors by Hruby, Victor J, Bartosz-Bechowski, Hubert, Davis, Peg, Slaninova, Jirina, Zalewska, Teresa, Stropova, Dagmar, Porreca, Frank, Yamamura, Henry I

“…Superpotent and highly δ-opioid receptor selective cyclic peptides of the general formula H-Tyr-c[d-Pen-Gly-Phe(p-X)-Pen]-Phe-OH (where X = hydrogen or…”
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Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation by Hosohata, Yoshiaki, Varga, Eva V., Stropova, Dagmar, Li, Xiaoping, Knapp, Richard J., Hruby, Victor J., Rice, Kenner C., Nagase, Hiroshi, Roeske, William R., Yamamura, Henry I.

“…Intrinsic activities of different δ opioid agonists were determined in a [ 35S]GTPγS binding assay using cell membranes from Chinese hamster ovary (CHO) cells…”
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Phosphorylation of adenylyl cyclase VI upon chronic δ-opioid receptor stimulation by Varga, Eva V, Stropova, Dagmar, Rubenzik, Marc, Waite, Sue, Roeske, William R, Yamamura, Henry I

“…An immunoprecipitation method was used to measure [ 32 P ]phosphate incorporation into the adenylyl cyclase VI protein in Chinese Hamster Ovary (CHO) cells…”
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Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphin A(1-11)-NH21 by LUNG, F.-D. T, COLLINS, N, STROPOVA, D, DAVIS, P, YAMAMURA, H. I, PORRECA, F, HRUBY, V. J

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Coupling of human delta-opioid receptor to retinal rod transducin in Chinese hamster ovary cells by Varga, E V, Stropova, D, Kim, T, Wang, M, Roeske, W R, Yamamura, H I

“…Reverse transcription-polymerase chain reaction was used to identify the pertussis toxin (Ptx)-sensitive G protein alpha-subunit pool in Chinese hamster ovary…”
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δ-Opioid receptor: the third extracellular loop determines naltrindole selectivity by Li, Xiaoping, Varga, Eva V., Stropova, Dagmar, Zalewska, Teresa, Malatynska, Ewa, Knapp, Richard J., Roeske, William R., Yamamura, Henry I.

“…Human δ/μ-opioid receptor chimeras were constructed to determine the role of the second and third extracellular loops in alkaloid ligand selectivity…”
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