Search Results - "Strop, Peter"

Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans by Smith, Kate E, Kelly, Amy C, Min, Catherine G, Weber, Craig S, McCarthy, Fiona M, Steyn, Leah V, Badarinarayana, Vasudeo, Stanton, J Brett, Kitzmann, Jennifer P, Strop, Peter, Gruessner, Angelika C, Lynch, Ronald M, Limesand, Sean W, Papas, Klearchos K

“…BACKGROUNDEncapsulation devices have the potential to enable cell-based insulin replacement therapies (such as human islet or stem cell–derived β cell…”
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One-bead-one-structure combinatorial libraries by Lebl, M, Krchnák, V, Sepetov, N F, Seligmann, B, Strop, P, Felder, S, Lam, K S

“…Combinatorial libraries employing the one-bead-one-compound technique are reviewed. Two distinguishing features characterize this technique. First, each…”
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Enzyme-Mediated Spatial Segregation on Individual Polymeric Support Beads: Application to Generation and Screening of Encoded Combinatorial Libraries by Vágner, Josef, Barany, George, Lam, Kit S., Krchn̆ák, Viktor, Sepetov, Nikolai F., Ostrem, James A., Strop, Peter, Lebl, Michal

“…Proteolysis of short Nα-protected peptide substrates bound to polyoxyethylene-polystyrene beads releases selectively free amino sites in the enzyme-accessible…”
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Discovery of a Novel, Potent, and Specific Family of Factor Xa Inhibitors via Combinatorial Chemistry by Ostrem, James A, Al-Obeidi, Fahad, Safar, Pavel, Safarova, Alena, Stringer, Steven K, Patek, Marcel, Cross, M. Todd, Spoonamore, James, LoCascio, Jeff C, Kasireddy, Padmaja, Thorpe, David S, Sepetov, Nikolai, Lebl, Michal, Wildgoose, Peter, Strop, Peter

“…A series of low molecular weight peptide inhibitors of factor Xa, unrelated to any previously described, was identified by screening a combinatorial peptide…”
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Sensitive, soluble chromogenic substrates for HIV-1 proteinase by RICHARDS, A. D, PHYLIP, L. H, KOSTKA, V, KAY, J, FARMERIE, W. G, SCARBOROUGH, P. E, ALVAREZ, A, DUNN, B. M, HIREL, P.-H, KONVALINKA, J, STROP, P, PAVLICKOVA, L

“…By replacement of the P1' residue in a capsid/nucleocapsid cleavage site mimic with 4-NO2-phenylalanine (Nph), an excellent chromogenic substrate,…”
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Structural and functional studies in vitro on the p6 protein from the HIV-1 gag open reading frame by Stys, D, Blaha, I, Strop, P

“…Protein p6 from HIV-1 gag open reading frame is reported to affect both the final phase of assembly of the viral particle and the early stage of the gag…”
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One bead-one compound combinatorial peptide library: different types of screening by Chen, C L, Strop, P, Lebl, M, Lam, K S

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Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases by Phylip, L H, Richards, A D, Kay, J, Kovalinka, J, Strop, P, Blaha, I, Velek, J, Kostka, V, Ritchie, A J, Broadhurst, A V

“…Kinetic constants (Km,Kcat) are derived for the hydrolysis of a number of chromogenic peptide substrates by the aspartic proteinase from HIV-2. The effect of…”
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Structural studies of the retroviral proteinase from avian myeloblastosis associated virus by Ohlendorf, D H, Foundling, S I, Wendoloski, J J, Sedlacek, J, Strop, P, Salemme, F R

“…The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure…”
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Myeloblastosis associated virus (MAV) proteinase site-mutated to be HIV-like has a higher activity and allows production of infectious but morphologically altered virus by Sedlacek, J, Fabry, M, Coward, J E, Horejsi, M, Strop, P, Luftig, R B

“…We have characterized the structure and infectivity of an avian retrovirus, myeloblastosis associated virus (MAV), containing a genetically altered proteinase…”
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Modifying the substrate specificity of chymosin by Quinn, D, Pitts, J E, Mantafounis, D, Lawler, S E, Uusitalo, J, Penttilä, M, Strop, P

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2D and 3D Spatially Addressed Arrays for High-Throughput Automated Synthesis of Combinatorial Libraries by Patek, Marcel, Safar, Pavel, Smrčina, Martin, Wegrzyniak, Eric, Bjergarde, Kirsten, Weichsel, Aleksandra, Strop, Peter

“…One of the key elements in the drug discovery process is the use of automation to synthesize libraries of compounds for biological screening. The…”
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THE CONSTRUCTION AND USE OF PEPTIDE AND NON-PEPTIDIC COMBINATORIAL LIBRARIES TO DISCOVER ENZYME INHIBITORS by Seligmann, Bruce, Abdul-Latif, Farid, Al-Obeidi, Fahad, Flegelova, Zuzana, Issakova, Olga, Kocis, Petr, Krchnak, Viktor, Lam, Kit, Lebl, Michal, Ostrem, James, Safar, Pavel, Sepetov, Nikolai, Stierandova, Alena, Strop and Peter Wildgoose, Peter

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