Search Results - "Strong, John M."

New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process by Huang, Shiew-Mei, Strong, John M., Zhang, Lei, Reynolds, Kellie S., Nallani, Srikanth, Temple, Robert, Abraham, Sophia, Habet, Sayed Al, Baweja, Raman K., Burckart, Gilbert J., Chung, Sang, Colangelo, Philip, Frucht, David, Green, Martin D., Hepp, Paul, Karnaukhova, Elena, Ko, Hon-Sum, Lee, Jang-Ik, Marroum, Patrick J., Norden, Janet M., Qiu, Wei, Rahman, Atiqur, Sobel, Solomon, Stifano, Toni, Thummel, Kenneth, Wei, Xiao-Xiong, Yasuda, Sally, Zheng, Jenny H., Zhao, Hong, Lesko, Lawrence J.

“…Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the…”
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Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study by Zhao, Ping, Ragueneau-Majlessi, Isabelle, Zhang, Lei, Strong, John M., Reynolds, Kellie S., Levy, Rene H., Thummel, Kenneth E., Huang, Shiew-Mei

“…The US Food and Drug Administration draft drug interaction guidance recommends that 400 mg ketoconazole (KTZ) be administered once daily for several days…”
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Drug Interactions/Review: New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process by Huang, Shiew-Mei, Strong, John M, Reynolds, Kellie S, Nallani, Srikanth, Temple, Robert, Abraham, Sophia, Al Habet, Sayed, Baweja, Raman K, Burckart, Gilbert J, Colangelo, Philip, Frucht, David, Green, Ma, Hepp, Paul, Karnaukhova, Elena, Ko, Hon-Sum, Lee, Jang-Ik, Marroum, Patrick J, Norden, Janet M, Rahman, Atiqur, Sobel, Solomon, Stifano, Toni, Thummel, Kenneth, Wei, Xiao-xiong, Yasuda, Sally, Zheng, Jenny H, Lesko, Lawrence J

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Scientific Perspectives on Drug Transporters and Their Role in Drug Interactions by Zhang, Lei, Strong, John M, Qiu, Wei, Lesko, Lawrence J, Huang, Shiew-Mei

“…Recently, increased interest in drug transporters and research in this area has revealed that drug transporters play an important role in modulating drug…”
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Reaction of Geldanamycin and C17-Substituted Analogues with Glutathione:  Product Identifications and Pharmacological Implications by Cysyk, Richard L, Parker, Robert J, Barchi, Joseph J, Steeg, Patricia S, Hartman, Neil R, Strong, John M

“…17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and 17-allylamino-17-demethoxygeldanamycin (17-AAG) are two derivatives of geldanamycin (GA) that…”
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Phase I study of the synthetic triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO), in advanced solid tumors by Speranza, Giovanna, Gutierrez, Martin E., Kummar, Shivaani, Strong, John M., Parker, Robert J., Collins, Jerry, Yu, Yunkai, Cao, Liang, Murgo, Anthony J., Doroshow, James H., Chen, Alice

“…Background The triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic Acid (CDDO, previously RTA 401) is a multifunctional molecule that controls cellular growth…”
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Stability and Comparative Metabolism of Selected Felbamate Metabolites and Postulated Fluorofelbamate Metabolites by Postmitochondrial Suspensions by Parker, Robert J, Hartman, Neil R, Roecklein, Bryan A, Mortko, Henry, Kupferberg, Harvey J, Stables, James, Strong, John M

“…Evidence has been presented suggesting that a reactive metabolite, 2-phenylpropenal (ATPAL), may be responsible for the toxicities observed during therapy with…”
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Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro by Kapetanovic, Izet M, Torchin, Cynthia D, Strong, John M, Yonekawa, Wayne D, Lu, Chuang, Li, Albert P, Dieckhaus, Christine M, Santos, Webster L, Macdonald, Timothy L, Sofia, R.Duane, Kupferberg, Harvey J

“…Antiepileptic therapy with a broad spectrum drug felbamate (FBM) has been limited due to reports of hepatotoxicity and aplastic anemia associated with its use…”
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Potentially Reactive Cyclic Carbamate Metabolite of the Antiepileptic Drug Felbamate Produced by Human Liver Tissue In Vitro by KAPETANOVIC, I. M, TORCHIN, C. D, THOMPSON, C. D, MILLER, T. A, MCNEILLY, P. J, MACDONALD, T. L, KUPFERBERG, H. J, PERHACH, J. L, SOFIA, R. D, STRONG, J. M

“…Felbamate (FBM) is a novel antiepileptic drug that was approved in 1993 for treatment of several forms of epilepsy. After its introduction, toxic reactions…”
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Production of intracellular 35S-glutathione by rat and human hepatocytes for the quantification of xenobiotic reactive intermediates by Hartman, Neil R, Cysyk, Richard L, Bruneau-Wack, Claudine, Thénot, Jean-Paul, Parker, Robert J, Strong, John M

“…The quantification and identification of xenobiotic reactive intermediates is difficult in the absence of highly radiolabeled drug. We have developed a method…”
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An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. I. Evidence for a confounding nonresponder phenotype by Weaver, J L, Contrera, J F, Rosenzweig, B A, Thompson, K L, Faustino, P J, Strong, J M, Ellison, C D, Anderson, L W, Prasanna, H R, Long-Bradley, P E, Lin, K K, Zhang, J, Sistare, F D

“…We have completed 2 26-wk studies to evaluate the hemizygous transgenic Tg.AC mouse, which has been proposed as an alternative short term model for testing…”
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4-demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine by WAUD, W. R, TIWARI, A, SCHMID, S. M, SHIH, T.-W, STRONG, J. M, HARTMAN, N. R, O'REILLY, S, STRUCK, R. F

“…Penclomedine [3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine], an antitumor agent, is currently in Phase I clinical trials and is believed to be a…”
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Pharmacokinetics of intraventricular and intravenous N,N',N″-triethylenethiophosphoramide (thiotepa) in rhesus monkeys and humans by STRONG, J. M, COLLINS, J. M, LESTER, C, POPLACK, D. G

“…The cerebrospinal fluid (CSF) and plasma pharmacokinetics of N,N',N"-triethylenethiophosphoramide (thiotepa), an alkylating agent used for treatment of…”
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Clinical pharmacology of 5-iodo-2'-deoxyuridine and 5-iodouracil and endogenous pyrimidine modulation by Klecker, Jr, R W, Jenkins, J F, Kinsella, T J, Fine, R L, Strong, J M, Collins, J M

“…We describe the clinical pharmacology and metabolism of 5-iodo-2'-deoxyuridine (IdUrd) during and after a 12-hour infusion. The kinetics of IdUrd were linear…”
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Glutamine and glutamate: automated quantification and isotopic enrichments by gas chromatography/mass spectrometry by Anderson, L W, Zaharevitz, D W, Strong, J M

“…A method is described for simultaneous quantification of glutamine and glutamate plasma levels and isotopic enrichments in these compounds. Glutamine and…”
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The involvement of cytochrome P450 3A4 in the N-demethylation of L-α-acetylmethadol (LAAM), norLAAM, and methadone by MOODY, D. E, ALBURGES, M. E, PARKER, R. J, COLLINS, J. M, STRONG, J. M

“…The N-demethylation of LAAM, norLAAM, and methadone has been investigated in human liver microsomes and microsomes containing cDNA-expressed human P450s. Gas…”
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Absolute bioavailability in man of N-acetylprocainamide determined by a novel stable isotope method by Strong, J M, Dutcher, J S, Lee, W K, Atkinson, Jr, A J

“…Absorption of a single oral dose of N-acetylprocainamide (NAPA) was studied in 3 normal subjects. Approximately 85% of the oral dose was absorbed and peak…”
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Identification of 6-mercaptopurine riboside in patients receiving 6-mercaptopurine as a prolonged intravenous infusion by Zimm, S, Grygiel, J J, Strong, J M, Monks, T J, Poplack, D G

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Simultaneous measurement of plasma concentratons of lidocaine and its deethylated metabolite by mass fragmentography by Strong, John M, Atkinson, Arthur J

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Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography by Takimoto, C H, Klecker, R W, Dahut, W L, Yee, L K, Strong, J M, Allegra, C J, Grem, J L

“…We have developed a sensitive HPLC assay to quantitate the active lactone form of 9-aminocamptothecin (9AC) in human plasma over the concentration range…”
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