Search Results - "Strong, Caroline E"

Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder by Strong, Caroline E, Kabbaj, Mohamed

“…Alcohol use disorder (AUD) is the most prevalent substance use disorder and causes a significant global burden. Relapse rates remain incredibly high after…”
Get full text

Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats by Dossat, Amanda M, Jourdi, Hussam, Wright, Katherine N, Strong, Caroline E, Sarkar, Ambalika, Kabbaj, Mohamed

“…Highlights • Gonadectomy negatively impacts PFC Zif268 expression, long-term memory, social interaction, and mood-related behaviors. • mPFC AAV-Zif268…”
Get full text

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening by Strong, Caroline E., Zhang, Jiajing, Carrasco, Martin, Kundu, Srikanya, Boutin, Molly, Vishwasrao, Harshad D., Liu, Jiamin, Medina, Angelica, Chen, Yu-Chi, Wilson, Kelli, Lee, Emily M., Ferrer, Marc

“…3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating…”
Get full text

High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors by Kundu, Srikanya, Boutin, Molly E., Strong, Caroline E., Voss, Ty, Ferrer, Marc

“…Three-dimensional (3D) organotypic models that capture native-like physiological features of tissues are being pursued as clinically predictive assays for…”
Get full text

A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids by Boutin, Molly E, Strong, Caroline E, Van Hese, Brittney, Hu, Xin, Itkin, Zina, Chen, Yu-Chi, LaCroix, Andrew, Gordon, Ryan, Guicherit, Oivin, Carromeu, Cassiano, Kundu, Srikanya, Lee, Emily, Ferrer, Marc

“…Discovery of therapeutics for neurological diseases is hampered by the lack of predictive in vitro and in vivo models. Traditionally, in vitro assays rely on…”
Get full text

Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress by Wright, Katherine N., Hagarty, Devin P., Strong, Caroline E., Schoepfer, Kristin J., Kabbaj, Mohamed

“…Background Ketamine has rapid antidepressant effects and shows great promise as a novel treatment for depression, but its limitations including its abuse…”
Get full text

Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice by Dossat, Amanda M., Wright, Katherine N., Strong, Caroline E., Kabbaj, Mohamed

“…Low-dose ketamine is a rapid-acting antidepressant, to which female rodents are more sensitive as compared to males. However, the mechanism mediating this sex…”
Get full text

Exploring ketamine’s reinforcement, cue-induced reinstatement, and nucleus accumbens cFos activation in male and female long evans rats by Hagarty, Devin P., Dawoud, Adam, Brea Guerrero, Alfonso, Phillips, Kaynas, Strong, Caroline E., Jennings, Sarah Dollie, Crawford, Michelle, Martinez, Katherine, Csernecky, Olivia, Saland, Samantha K., Kabbaj, Mohamed

“…Ketamine (KET), a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has rapid onset of antidepressant effects in Treatment-Resistant Depression…”
Get full text

Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner by Wright, Katherine N, Hollis, Fiona, Duclot, Florian, Dossat, Amanda M, Strong, Caroline E, Francis, T Chase, Mercer, Roger, Feng, Jian, Dietz, David M, Lobo, Mary Kay, Nestler, Eric J, Kabbaj, Mohamed

“…Epigenetic mechanisms, such as histone modifications, regulate responsiveness to drugs of abuse, such as cocaine, but relatively little is known about the…”
Get full text

Reinforcing properties of an intermittent, low dose of ketamine in rats: effects of sex and cycle by Wright, Katherine N., Strong, Caroline E., Addonizio, Marjorie N., Brownstein, Naomi C., Kabbaj, Mohamed

“…Rationale Repeated intermittent exposure to ketamine has rapid and long-lasting antidepressant effects, but the abuse potential has only been assessed at high…”
Get full text

Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats by Schoepfer, Kristin J., Strong, Caroline E., Saland, Samantha K., Wright, Katherine N., Kabbaj, Mohamed

“…Subanesthetic ketamine (KET) elicits rapid, robust, but transient antidepressant effects. KET's antidepressant actions can be augmented and maintained for a…”
Get full text

Sex and Individual Differences in Alcohol Intake Are Associated with Differences in Ketamine Self-Administration Behaviors and Nucleus Accumbens Dendritic Spine Density by Strong, Caroline E, Wright, Katherine N, Kabbaj, Mohamed

“…Clinical and preclinical studies have shown that ketamine, an NMDA receptor antagonist, has promising therapeutic value for the treatment of alcohol use…”
Get full text

Optogenetic inhibition of medial prefrontal cortex projections to the nucleus accumbens core and methyl supplementation via L‐Methionine attenuates cocaine‐primed reinstatement by WRIGHT, Katherine N., DOSSAT, Amanda M., STRONG, Caroline E., SAILER, Lindsay L., PAVLOCK, Samantha M., KABBAJ, Mohamed

“…DNA methylation has been identified as a powerful and activity‐dependent regulator of changes in the brain that may underlie neuroadaptations in response to…”
Get full text

Methyl Supplementation Attenuates Cocaine-Seeking Behaviors and Cocaine-Induced c-Fos Activation in a DNA Methylation-Dependent Manner by Wright, Katherine N, Hollis, Fiona, Duclot, Florian, Dossat, Amanda M, Strong, Caroline E, Francis, T Chase, Mercer, Roger, Feng, Jian, Dietz, David M, Lobo, Mary Kay, Nestler, Eric J, Kabbaj, Mohamed

“…Epigenetic mechanisms, such as histone modifications, regulate responsiveness to drugs of abuse, such as cocaine, but relatively little is known about the…”
Get full text