Search Results - "Stromnes, Ingunn M"

Active induction of experimental allergic encephalomyelitis by Goverman, Joan M, Stromnes, Ingunn M

“…This protocol details a method to actively induce experimental allergic encephalomyelitis (EAE), a widely used animal model for studies of multiple sclerosis…”
Get full text

Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma by Schmiechen, Zoe C, Stromnes, Ingunn M

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with an overall 5-year survival rate of 10%. Disease lethality is due to late diagnosis, early…”
Get full text

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma by Stromnes, Ingunn M., Schmitt, Thomas M., Hulbert, Ayaka, Brockenbrough, J. Scott, Nguyen, Hieu N., Cuevas, Carlos, Dotson, Ashley M., Tan, Xiaoxia, Hotes, Jennifer L., Greenberg, Philip D., Hingorani, Sunil R.

“…Pancreatic ductal adenocarcinomas (PDAs) erect physical barriers to chemotherapy and induce multiple mechanisms of immune suppression, creating a sanctuary for…”
Get full text

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma by Burrack, Adam L., Spartz, Ellen J., Raynor, Jackson F., Wang, Iris, Olson, Margaret, Stromnes, Ingunn M.

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDA mouse model and show that neoantigen expression is…”
Get full text

Molecular pathways: myeloid complicity in cancer by Stromnes, Ingunn M, Greenberg, Philip D, Hingorani, Sunil R

“…Cancer-induced inflammation results in accumulation of myeloid cells. These myeloid cells include progenitors and progeny of monocytes, granulocytes,…”
Get full text

Passive induction of experimental allergic encephalomyelitis by Stromnes, Ingunn M, Goverman, Joan M

“…Experimental allergic encephalomyelitis (EAE) is a widely used animal model of the human demyelinating disease multiple sclerosis. EAE is initiated by…”
Get full text

Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma by Patterson, Michael T., Burrack, Adam L., Xu, Yingzheng, Hickok, Grant H., Schmiechen, Zoe C., Becker, Samuel, Cruz-Hinojoza, Eduardo, Schrank, Patricia R., Kennedy, Ainsley E., Firulyova, Maria M., Miller, Ebony A., Zaitsev, Konstantin, Williams, Jesse W., Stromnes, Ingunn M.

“…Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages…”
Get full text

Germline T cell receptor exchange results in physiological T cell development and function by Rollins, Meagan R., Raynor, Jackson F., Miller, Ebony A., Butler, Jonah Z., Spartz, Ellen J., Lahr, Walker S., You, Yun, Burrack, Adam L., Moriarity, Branden S., Webber, Beau R., Stromnes, Ingunn M.

“…T cell receptor (TCR) transgenic mice represent an invaluable tool to study antigen-specific immune responses. In the pre-existing models, a monoclonal TCR is…”
Get full text

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies by Anderson, Kristin G., Stromnes, Ingunn M., Greenberg, Philip D.

“…T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor…”
Get full text

IL18 at the Crossroads between Chronic Inflammation and T-cell Exhaustion in Pancreatic Cancer by Stromnes, Ingunn M

“…Chronic inflammation and immune evasion are hallmarks of cancer. Cancer promotes T-cell differentiation toward an exhausted, or dysfunctional state, which…”
Get more information

Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer by Burrack, Adam L, Schmiechen, Zoe C, Patterson, Michael T, Miller, Ebony A, Spartz, Ellen J, Rollins, Meagan R, Raynor, Jackson F, Mitchell, Jason S, Kaisho, Tsuneyasu, Fife, Brian T, Stromnes, Ingunn M

“…We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid…”
Get full text

Vaccination Alters the Balance between Protective Immunity, Exhaustion, Escape, and Death in Chronic Infections by JOHNSON, Philip L. F, KOCHIN, Beth F, MCAFEE, Megan S, STROMNES, Ingunn M, REGOES, Roland R, AHMED, Rafi, BLATTMAN, Joseph N, ANTIA, Rustom

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

CD39 deletion in TCR-engineered T cells enhances antitumour immunity by Tsai, Alexander K, Stromnes, Ingunn M

Get more information

An aged immune system drives senescence and ageing of solid organs by Yousefzadeh, Matthew J., Flores, Rafael R., Zhu, Yi, Schmiechen, Zoe C., Brooks, Robert W., Trussoni, Christy E., Cui, Yuxiang, Angelini, Luise, Lee, Kyoo-A, McGowan, Sara J., Burrack, Adam L., Wang, Dong, Dong, Qing, Lu, Aiping, Sano, Tokio, O’Kelly, Ryan D., McGuckian, Collin A., Kato, Jonathan I., Bank, Michael P., Wade, Erin A., Pillai, Smitha P. S., Klug, Jenna, Ladiges, Warren C., Burd, Christin E., Lewis, Sara E., LaRusso, Nicholas F., Vo, Nam V., Wang, Yinsheng, Kelley, Eric E., Huard, Johnny, Stromnes, Ingunn M., Robbins, Paul D., Niedernhofer, Laura J.

“…Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly 1 , 2 . To define the contribution of immune system…”
Get full text

"Couple's Immunotherapy": Is CXCL13 at the Heart of the Prescription? by Cruz-Hinojoza, Eduardo, Stromnes, Ingunn M

“…Sex differences in cancer survivorship and response to immunotherapy have been observed, with males generally displaying better outcomes to immune checkpoint…”
Get more information

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma by Stromnes, Ingunn M, Hulbert, Ayaka, Pierce, Robert H, Greenberg, Philip D, Hingorani, Sunil R

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to most therapies, including immune checkpoint blockade. To elucidate mechanisms of…”
Get more information

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity by Stromnes, Ingunn M, Brockenbrough, J Scott, Izeradjene, Kamel, Carlson, Markus A, Cuevas, Carlos, Simmons, Randi M, Greenberg, Philip D, Hingorani, Sunil R

“…Pancreatic ductal adenocarcinoma (PDA) is characterised by a robust desmoplasia, including the notable accumulation of immunosuppressive cells that shield…”
Get more information

B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system by Pierson, Emily R, Stromnes, Ingunn M, Goverman, Joan M

“…The efficacy of rituximab treatment in multiple sclerosis has renewed interest in the role of B cells in CNS autoimmunity. In this study, we show that B cells…”
Get full text

Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells by Stromnes, Ingunn M, Cerretti, Lauren M, Liggitt, Denny, Harris, Robert A, Goverman, Joan M

“…Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system (CNS) characterized by a wide range of clinical signs. The location…”
Get full text

Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report by Patterson, Michael T, Xu, Yingzheng, Hillman, Hannah, Osinski, Victoria, Schrank, Patricia R, Kennedy, Ainsley E, Barrow, Fanta, Zhu, Alisha, Tollison, Samuel, Shekhar, Sia, Stromnes, Ingunn M, Tassi, Ilaria, Wu, Dick, Revelo, Xavier S, Binstadt, Bryce A, Williams, Jesse W

“…Trem2 (triggering receptor on myeloid cells 2), a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell…”
Get full text