Search Results - "Strom, Terry"

Immunologic Basis of Graft Rejection and Tolerance Following Transplantation of Liver or Other Solid Organs by Sánchez–Fueyo, Alberto, Strom, Terry B

“…Transplantation of organs between genetically different individuals of the same species causes a T cell–mediated immune response that, if left unchecked,…”
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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells by Korn, Thomas, Bettelli, Estelle, Gao, Wenda, Awasthi, Amit, Jäger, Anneli, Strom, Terry B, Oukka, Mohamed, Kuchroo, Vijay K

“…On activation, naive T cells differentiate into effector T-cell subsets with specific cytokine phenotypes and specialized effector functions. Recently a subset…”
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells by BETTELLI, Estelle, CARRIER, Yijun, WENDA GAO, KORN, Thomas, STROM, Terry B, OUKKA, Mohamed, WEINER, Howard L, KUCHROO, Vijay K

“…On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (T(H)) cells are…”
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In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche by Fujisaki, Joji, Wu, Juwell, Carlson, Alicia L., Silberstein, Lev, Putheti, Prabhakar, Larocca, Rafael, Gao, Wenda, Saito, Toshiki I., Celso, Cristina Lo, Tsuyuzaki, Hitoshi, Sato, Tatsuyuki, Côté, Daniel, Sykes, Megan, Strom, Terry B., Scadden, David T., Lin, Charles P.

“…A privileged position A new study identifies the bone marrow haematopoietic stem cell (HSC) niche — a specialized microenvironment where stem cells reside — as…”
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IL-4 inhibits TGF-β-induced Foxp3 + T cells and, together with TGF-β, generates IL-9 + IL-10 + Foxp3 − effector T cells by Oukka, Mohamed, Mitsdoerffer, Meike, Strom, Terry B, Kuchroo, Vijay K, Elyaman, Wassim, Dardalhon, Valérie, Galileos, George, Awasthi, Amit, Sobel, Raymond A, Ho, I-Cheng, Kwon, Hyoung, Gao, Wenda, Khoury, Samia

“…Foxp3 is required for the generation and function of regulatory T cells. Kuchroo and colleagues find that interleukin 4 blocks the generation of these cells…”
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression by Deaglio, Silvia, Dwyer, Karen M, Gao, Wenda, Friedman, David, Usheva, Anny, Erat, Anna, Chen, Jiang-Fan, Enjyoji, Keiichii, Linden, Joel, Oukka, Mohamed, Kuchroo, Vijay K, Strom, Terry B, Robson, Simon C

“…The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We…”
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Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation by Xiao, Sheng, Bod, Lloyd, Pochet, Nathalie, Kota, Savithri Balasubramanian, Hu, Dan, Madi, Asaf, Kilpatrick, Jessica, Shi, Jingwen, Ho, Allen, Zhang, Huiyuan, Sobel, Raymond, Weiner, Howard L., Strom, Terry B., Quintana, Francisco J., Joller, Nicole, Kuchroo, Vijay K.

“…Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B…”
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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation by Oukka, Mohamed, Kuchroo, Vijay K, Korn, Thomas, Reddy, Jayagopala, Gao, Wenda, Bettelli, Estelle, Awasthi, Amit, Petersen, Troels R, Bäckström, B Thomas, Sobel, Raymond A, Wucherpfennig, Kai W, Strom, Terry B

“…Treatment with ex vivo-generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases…”
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Clinical islet transplantation: advances and immunological challenges by Ricordi, Camillo, Strom, Terry B

“…Type 1 diabetes mellitus results from autoimmune destruction of the insulin-secreting cells in the pancreas. Daily treatment with exogenous insulin is…”
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Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs by Gupta, Shipra, Thornley, Thomas B, Gao, Wenda, Larocca, Rafael, Turka, Laurence A, Kuchroo, Vijay K, Strom, Terry B

“…Tregs play a pivotal role in inducing and maintaining donor-specific transplant tolerance. The T cell immunoglobulin and mucin domain-3 protein (TIM-3) is…”
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Reciprocal generation of Th1/Th17 and Treg cells by B1 and B2 B cells by Zhong, Xuemei, Gao, Wenda, Degauque, Nicolas, Bai, Chunyan, Lu, Yan, Kenny, James, Oukka, Mohamed, Strom, Terry B, Rothstein, Thomas L

“…Regulatory T (Treg) cells are indispensable for maintaining peripheral tolerance, whereas T helper (Th)1 and Th17 cells induce inflammation and tissue…”
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Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label by Carlson, Alicia L, Fujisaki, Joji, Wu, Juwell, Runnels, Judith M, Turcotte, Raphaël, Spencer, Joel A, Celso, Cristina Lo, Scadden, David T, Strom, Terry B, Lin, Charles P

“…We describe a novel photoconversion technique to track individual cells in vivo using a commercial lipophilic membrane dye, DiR. We show that DiR exhibits a…”
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TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines by Hastings, William D., Anderson, David E., Kassam, Nasim, Koguchi, Ken, Greenfield, Edward A., Kent, Sally C., Zheng, Xin Xiao, Strom, Terry B., Hafler, David A., Kuchroo, Vijay K.

“…TIM‐3 is a molecule selectively expressed on a subset of murine IFN‐γ‐secreting T helper 1 (Th1) cells but not Th2 cells, and regulates Th1 immunity and…”
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Human CD4 memory T cells can become CD4+IL-9+ T cells by Putheti, Prabhakar, Awasthi, Amit, Popoola, Joyce, Gao, Wenda, Strom, Terry B

“…IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+)…”
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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity by Kuchroo, Vijay K, Zhu, Chen, Anderson, Ana C, Schubart, Anna, Xiong, Huabao, Imitola, Jaime, Khoury, Samia J, Zheng, Xin Xiao, Strom, Terry B

“…Tim-3 is a T helper type 1 (T(H)1)-specific cell surface molecule that seems to regulate T(H)1 responses and the induction of peripheral tolerance. However,…”
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Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery by Park, Jason, Gao, Wenda, Whiston, Roy, Strom, Terry B, Metcalfe, Su, Fahmy, Tarek M

“…Within the immune system there is an exquisite ability to discriminate between “self” and “non-self” that is orchestrated by antigen-specific T lymphocytes…”
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Transplant rejection and paradigms lost by Strom, Terry B

“…During transplant rejection, migrating T cells infiltrate the grafted organ, but the signals that direct this migration are incompletely understood. In this…”
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T-Regulatory Cells Shift from a Protective Anti-inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis by GOUNARIS, Elias, BLATNER, Nichole R, DENNIS, Kristen, MAGNUSSON, Fay, GURISH, Michael F, STROM, Terry B, BECKHOVE, Philipp, GOUNARI, Fotini, KHAZAIE, Khashayarsha

“…T-regulatory (Treg) cells play a major role in cancer by suppressing protective antitumor immune responses. A series of observations (from a single laboratory)…”
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Mast cells are essential intermediaries in regulatory T-cell tolerance by Van Snick, Jacques, Noelle, Randolph J, Gondek, David C, Lind, Evan F, Strom, Terry B, Zheng, Xin Xiao, Gleeson, Michael W, Pino-Lagos, Karina, Scott, Zachary A, Bennett, Kathy A, Lu, Li-Fan, Reed, Jennifer L, Coyle, Anthony J

“…Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained in this study establish that mast cells are essential in…”
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Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory by Thornley, Thomas B, Fang, Zemin, Balasubramanian, Savithri, Larocca, Rafael A, Gong, Weihua, Gupta, Shipra, Csizmadia, Eva, Degauque, Nicolas, Kim, Beom Seok, Koulmanda, Maria, Kuchroo, Vijay K, Strom, Terry B

“…Macrophages characterized as M2 and M2-like regulate immune responses associated with immune suppression and healing; however, the relationship of this…”
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