Search Results - "Strom, Amy R"

The liquid nucleome - phase transitions in the nucleus at a glance by Strom, Amy R, Brangwynne, Clifford P

“…Cells organize membrane-less internal compartments through a process called liquid-liquid phase separation (LLPS) to create chemically distinct compartments,…”
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Nucleated transcriptional condensates amplify gene expression by Wei, Ming-Tzo, Chang, Yi-Che, Shimobayashi, Shunsuke F., Shin, Yongdae, Strom, Amy R., Brangwynne, Clifford P.

“…Membraneless organelles or condensates form through liquid–liquid phase separation 1 – 4 , which is thought to underlie gene transcription through condensation…”
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Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization by Sanders, David W., Kedersha, Nancy, Lee, Daniel S.W., Strom, Amy R., Drake, Victoria, Riback, Joshua A., Bracha, Dan, Eeftens, Jorine M., Iwanicki, Allana, Wang, Alicia, Wei, Ming-Tzo, Whitney, Gena, Lyons, Shawn M., Anderson, Paul, Jacobs, William M., Ivanov, Pavel, Brangwynne, Clifford P.

“…Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate…”
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HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics by Strom, Amy R, Biggs, Ronald J, Banigan, Edward J, Wang, Xiaotao, Chiu, Katherine, Herman, Cameron, Collado, Jimena, Yue, Feng, Ritland Politz, Joan C, Tait, Leah J, Scalzo, David, Telling, Agnes, Groudine, Mark, Brangwynne, Clifford P, Marko, John F, Stephens, Andrew D

“…Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone…”
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The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic by Swenson, Joel M, Colmenares, Serafin U, Strom, Amy R, Costes, Sylvain V, Karpen, Gary H

“…Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions. To…”
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The mechanobiology of nuclear phase separation by Lee, Daniel S. W., Strom, Amy R., Brangwynne, Clifford P.

“…The cell nucleus can be thought of as a complex, dynamic, living material, which functions to organize and protect the genome and coordinate gene expression…”
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Phase separation drives heterochromatin domain formation by Strom, Amy R., Emelyanov, Alexander V., Mir, Mustafa, Fyodorov, Dmitry V., Darzacq, Xavier, Karpen, Gary H.

“…HP1a can nucleate into foci that display liquid properties during the early stages of heterochromatin domain formation in Drosophila embryos, suggesting that…”
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Using the game of Mastermind to teach, practice, and discuss scientific reasoning skills by Strom, Amy R, Barolo, Scott

“…The codebreaker takes a guess at the code (i.e., performs an experiment), interprets the feedback provided by the codemaker (i.e., the result of the…”
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Compartmentalization of telomeres through DNA-scaffolded phase separation by Jack, Amanda, Kim, Yoonji, Strom, Amy R, Lee, Daniel S W, Williams, Byron, Schaub, Jeffrey M, Kellogg, Elizabeth H, Finkelstein, Ilya J, Ferro, Luke S, Yildiz, Ahmet, Brangwynne, Clifford P

“…Telomeres form unique nuclear compartments that prevent degradation and fusion of chromosome ends by recruiting shelterin proteins and regulating access of DNA…”
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A disordered region controls cBAF activity via condensation and partner recruitment by Patil, Ajinkya, Strom, Amy R., Paulo, Joao A., Collings, Clayton K., Ruff, Kiersten M., Shinn, Min Kyung, Sankar, Akshay, Cervantes, Kasey S., Wauer, Tobias, St. Laurent, Jessica D., Xu, Grace, Becker, Lindsay A., Gygi, Steven P., Pappu, Rohit V., Brangwynne, Clifford P., Kadoch, Cigall

“…Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing dogma is that IDRs engage in…”
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Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity by Strom, Amy R, Kim, Yoonji, Zhao, Hongbo, Chang, Yi-Che, Orlovsky, Natalia D, Košmrlj, Andrej, Storm, Cornelis, Brangwynne, Clifford P

“…Biomolecular condensates assemble in living cells through phase separation and related phase transitions. An underappreciated feature of these dynamic…”
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Viscoelasticity and advective flow of RNA underlies nucleolar form and function by Riback, Joshua A, Eeftens, Jorine M, Lee, Daniel S W, Quinodoz, Sofia A, Donlic, Anita, Orlovsky, Natalia, Wiesner, Lennard, Beckers, Lien, Becker, Lindsay A, Strom, Amy R, Rana, Ushnish, Tolbert, Michele, Purse, Byron W, Kleiner, Ralph, Kriwacki, Richard, Brangwynne, Clifford P

“…The nucleolus is the largest biomolecular condensate and facilitates transcription, processing, and assembly of ribosomal RNA (rRNA). Although nucleolar…”
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Interplay of condensation and chromatin binding underlies BRD4 targeting by Strom, Amy R, Eeftens, Jorine M, Polyachenko, Yury, Weaver, Claire J, Watanabe, Hans-Frederick, Bracha, Dan, Orlovsky, Natalia D, Jumper, Chanelle C, Jacobs, William M, Brangwynne, Clifford P

“…Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain…”
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Light-controlled 3D genome reorganization through capillary forces by Kim, Yoonji, Strom, Amy R., Brangwynne, Clifford P.

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Multivalency of Proteins and their Interactions Predict their Phase Separation by Deviri, Dan, Strom, Amy R., Karpen, Gary, Safran, Samuel

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The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic by Swenson, Joel M., Colmenares, Serafin U., Strom, Amy R., Costes, Sylvain V., Karpen, Gary H.

“…Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions. To…”
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Compartmentalization of telomeres through DNA-scaffolded phase separation by Jack, Amanda, Kim, Yoonji, Strom, Amy R., Lee, Daniel S., Williams, Byron, Schaub, Jeffrey M., Kellogg, Elizabeth H., Finkelstein, Ilya J., Ferro, Luke, Yildiz, Ahmet, Brangwynne, Clifford P.

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Phase-Separation Driven Heterochromatin Formation: Experiment and Theory by Deviri, Dan, Strom, Amy R., Colmenares, Serafin, Wilson, Shelby, Hickmann, Collin, Karpen, Gary, Safran, Samuel

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Phase Separation Drives Heterochromatin Domain Formation by Strom, Amy R., Emelyanov, Alexander V., Mir, Mustafa R., Fyodorov, Dmitry V., Darzacq, Xavier R., Karpen, Gary H.

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HP1[alpha] is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics by Strom, Amy R, Biggs, Ronald J, Banigan, Edward J, Wang, Xiaotao, Chiu, Katherine, Herman, Cameron, Collado, Jimena, Yue, Feng, Ritland Politz, Joan C, Tait, Leah J, Scalzo, David, Telling, Agnes, Groudine, Mark, Brangwynne, Clifford P, Marko, John F, Stephens, Andrew D

“…Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone…”
Get full text