Search Results - "Strolin‐Benedetti, Margherita"

Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics by Strolin Benedetti, Margherita, Whomsley, Rhys, Baltes, Eugène

“…Although the majority of oxidative metabolic reactions are mediated by the CYP superfamily of enzymes, non-CYP-mediated oxidative reactions can play an…”
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Inhibition of allergen‐induced wheal and flare reactions by levocetirizine and desloratadine by Frossard, Nelly, Strolin‐Benedetti, Margherita, Purohit, Ashok, Pauli, Gabrielle

“…What is already known about this subject • The reproducible and standardized histamine‐induced wheal and flare model helps identify the objective effectiveness…”
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The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines by Gillman, Sherwin, Gillard, Michel, Strolin Benedetti, Margherita

“…Second generation H1 antihistamines are considered first-line therapy for allergic rhinitis and chronic idiopathic urticaria, largely because of their…”
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Enzyme induction and inhibition by new antiepileptic drugs: a review of human studies by Benedetti, Margherita Strolin

“…— The aim of this paper is to review a number of new antiepileptic agents (i.e. felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine,…”
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Biotransformation of xenobiotics by amine oxidases by Benedetti, Margherita Strolin

“…Although the cytochrome P450 (CYP) system ranks first in terms of catalytic versatility and the wide range of xenobiotics it detoxifies or activates to…”
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A small molecule that mimics the metabolic activity of copper-containing amine oxidases (CuAOs) toward physiological mono- and polyamines by Largeron, Martine, Fleury, Maurice-Bernard, Strolin Benedetti, Margherita

“…Primary aliphatic biogenic amines have been successfully oxidized using a quinonoid species that mimics the metabolic activity of copper-containing amine…”
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Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? by Strolin Benedetti, Margherita, Tipton, Keith F., Whomsley, Rhys

“…In this review, the major enzyme systems involved in vivo in the oxidative metabolism of xenobiotic amines in humans are discussed, i.e. the monooxygenases…”
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A neurotoxin N-methyl( R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells by Maruyama, Wakako, Strolin Benedetti, Margherita, Takahashi, Tsutomu, Naoi, Makoto

“…In retinoic acid-differentiated SH-SY5Y cells an endogenous neurotoxin N-methyl( R)salsolinol induced apoptotic cell death. Using a single cell gel…”
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Continuous versus on-demand pharmacotherapy of allergic rhinitis: Evidence and practice by Laekeman, Gert, Simoens, Steven, Buffels, Johan, Gillard, Michel, Robillard, Thibert, Benedetti, Margherita Strolin, Watelet, Jean-Baptiste, Liekendael, Georges, Ghys, Liesbet, Church, Martin

“…Summary This review aims to compare continuous with on-demand pharmacotherapy of allergic rhinitis by focusing on pharmacodynamic, pharmacokinetic, safety,…”
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Relevance of H1 -receptor occupancy to H1 -antihistamine dosing in children by Simons, Keith J., PhD, Benedetti, Margherita Strolin, PhD, Simons, F. Estelle R., MD, FRCPC, Gillard, Michel, PhD, Baltes, Eugene, PhD

“…[...]by using the unbound (free) levocetirizine plasma concentrations and in vitro affinity data, medication concentrations at receptor sites were calculated,…”
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Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers by BENEDETTI, Margherita Strolin, PLISNIER, Michel, KAISE, Jacques, MAIER, Laura, BALTES, Eugène, ARENDT, Catherine, MCCRACKEN, Nigel

“…The main goal of the present study was to investigate the absorption and disposition of levocetirizine dihydrochloride, the R enantiomer of cetirizine…”
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Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency by Whomsley, Rhys, Strolin‐Benedetti, Margherita, Baltes, Eugène

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Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers by Fornasini, Gianfranco, Monti, Nunzia, Brogin, Giandomenico, Gallina, Maddalena, Eandi, Mario, Persiani, Stefano, Bani, Massimo, Pepa, Carlo Della, Zara, Gianpaolo, Benedetti, Margherita Strolin

“…The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800…”
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Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers by Baltes, Eugène, Coupez, René, Giezek, Hilde, Voss, Gudrun, Meyerhoff, Carsten, Benedetti, Margherita Strolin

“…The primary objective of the present study was to compare the absorption and disposition of levocetirizine, the eutomer of cetirizine, when administered alone…”
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(R)salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes by Naoi, M, Maruyama, W, Nakao, N, Ibi, T, Sahashi, K, Benedetti, M S

“…Recently, an endogenous catechol isoquinoline, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl(R)salsolinol], was proved to be a…”
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Pharmacokinetics and metabolism of 14C-levetiracetam, a new antiepileptic agent, in healthy volunteers by STROLIN BENEDETTI, Margherita, WHOMSLEY, Rhys, NICOLAS, Jean-Marie, YOUNG, Colin, BALTES, Eugène

“…The absorption, disposition and metabolism of levetiracetam, a new antiepileptic drug, have been investigated after a single oral dose of the (14)C-labelled…”
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Is it important to correct apparent drug tissue concentrations for blood contamination in the dog? by Giudicelli, Christine, Dricot, Eric, Moati, Frédérique, Strolin-Benedetti, Margherita, Giudicelli, Jean-François

“…The goal of this study was to quantify in the dog the error that is made in assessing drug tissue concentrations when no correction for blood contamination is…”
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Blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans by Bree, Françoise, Thiault, Laetitia, Gautiers, Gwenaelle, Benedetti, Margherita Strolin, Baltes, Eugène, Rihoux, Jean-Pierre, Tillement, Jean-Paul

“…The aim of the present study was to determine (1) the extent of levocetirizine binding to human blood cells, plasma and individual plasma proteins; (2) the…”
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Pharmacokinetics and metabolism of 14 C-levetiracetam, a new antiepileptic agent, in healthy volunteers by Strolin Benedetti, Margherita, Whomsley, Rhys, Nicolas, Jean-Marie, Young, Colin, Baltes, Eug ne

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Stereoselective and species-dependent kinetics of reboxetine in mouse and rat by Strolin Benedetti, M, Frigerio, E, Tocchetti, P, Brianceschi, G, Castelli, M G, Pellizzoni, C, Dostert, P

“…Reboxetine, (RS)-2-[(RS)-alpha-(2-ethoxyphenoxy)benzyl]morpholine methanesulphonate, is a racemic compound and consists of a mixture of the (R,R)- and…”
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