Search Results - "Strobel, Eric D."

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes by Goodwin, Nicole C, Ding, Zhi-Ming, Harrison, Bryce A, Strobel, Eric D, Harris, Angela L, Smith, Melinda, Thompson, Andrea Y, Xiong, Wendy, Mseeh, Faika, Bruce, Debra J, Diaz, Damaris, Gopinathan, Suma, Li, Ling, O’Neill, Emily, Thiel, Mary, Wilson, Alan G. E, Carson, Kenneth G, Powell, David R, Rawlins, David B

“…The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters…”
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LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice by Powell, David R, Smith, Melinda G, Doree, Deon D, Harris, Angela L, Greer, Jennifer, DaCosta, Christopher M, Thompson, Andrea, Jeter-Jones, Sabrina, Xiong, Wendy, Carson, Kenneth G, Goodwin, Nicole C, Harrison, Bryce A, Rawlins, David B, Strobel, Eric D, Gopinathan, Suma, Wilson, Alan, Mseeh, Faika, Zambrowicz, Brian, Ding, Zhi-Ming

“…LX2761 is a potent sodium/glucose cotransporter 1 inhibitor restricted to the intestinal lumen after oral administration. Studies presented here evaluated the…”
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Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads by Huang, Yifang, Strobel, Eric D., Ho, Chih Y., Reynolds, Charles H., Conway, Kelly A., Piesvaux, Jennifer A., Brenneman, Douglas E., Yohrling, George J., Moore Arnold, H., Rosenthal, Daniel, Alexander, Richard S., Tounge, Brett A., Mercken, Marc, Vandermeeren, Marc, Parker, Michael H., Reitz, Allen B., Baxter, Ellen W.

“…Structural biology allowed the identification of 7 as a potent BACE inhibitor (IC 50 = 5 nM). We have identified macrocyclic inhibitors of the aspartic…”
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Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor by Robinson, Reeder M., Reyes, Leticia, Duncan, Ravyn M., Bian, Haiyan, Strobel, Eric D., Hyman, Sarah L., Reitz, Allen B., Dolloff, Nathan G.

“…Protein disulfide isomerase (PDI, PDIA1) is an emerging therapeutic target in oncology. PDI inhibitors have demonstrated a unique propensity to selectively…”
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Potency of a small molecule that targets the molluscum contagiosum virus processivity factor increases when conjugated to a tripeptide by Guan, Hancheng, Nuth, Manunya, Scott, Richard W., Parker, Michael H., Strobel, Eric D., Reitz, Allen B., Kulp, John L., Ricciardi, Robert P.

“…We recently developed compound FC-7269 for targeting the Molluscum contagiosum virus processivity factor (mD4) and demonstrated its ability to inhibit viral…”
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A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potential by Guan, Hancheng, Nuth, Manunya, Isaacs, Stuart N., Xiao, Yuhong, Scott, Richard W., Parker, Michael H., Strobel, Eric D., Kulp, John L., Bailey, Thomas R., Reitz, Allen B., Ricciardi, Robert P.

“…Molluscum contagiosum (MC) is an infectious disease that occurs only in humans with a tropism that is narrowly restricted to the outermost epidermal layer of…”
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Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation by Goodwin, Nicole C, Cianchetta, Giovanni, Burgoon, Hugh A, Healy, Jason, Mabon, Ross, Strobel, Eric D, Allen, Jason, Wang, Shuli, Hamman, Brian D, Rawlins, David B

“…The first allosteric, type III inhibitor of LIM-kinase 2 (LIMK2) is reported. A series of molecules that feature both an N-phenylsulfonamide and tertiary amide…”
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Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor by Nuth, Manunya, Guan, Hancheng, Xiao, Yuhong, Kulp, John L., Parker, Michael H., Strobel, Eric D., Isaacs, Stuart N., Scott, Richard W., Reitz, Allen B., Ricciardi, Robert P.

“…The smallpox virus (variola) remains a bioterrorism threat since a majority of the human population has never been vaccinated. In the event of an outbreak, at…”
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(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines:  Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells by Ho, Chih Y, Ludovici, Donald W, Maharoof, Umar S. M, Mei, Jay, Sechler, Jan L, Tuman, Robert W, Strobel, Eric D, Andraka, Laura, Yen, Hwa-Kwo, Leo, Gregory, Li, Jian, Almond, Harold, Lu, Hong, DeVine, Ann, Tominovich, Rose M, Baker, Judith, Emanuel, Stuart, Gruninger, Robert H, Middleton, Steven A, Johnson, Dana L, Galemmo, Robert A

“…A series of (6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines has been optimized to preserve both potent kinase inhibition activity against the…”
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