Search Results - "Stritt, Simon"

Homeostatic maintenance of the lymphatic vasculature by Stritt, Simon, Koltowska, Katarzyna, Mäkinen, Taija

“…The lymphatic vasculature is emerging as a multifaceted regulator of tissue homeostasis and regeneration. Lymphatic vessels drain fluid, macromolecules, and…”
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Inherited platelet diseases with normal platelet count: phenotypes, genotypes and diagnostic strategy by Nurden, Paquita, Stritt, Simon, Favier, Remi, Nurden, Alan T

“…Inherited platelet disorders resulting from platelet function defects and a normal platelet count cause a moderate or severe bleeding diathesis. Since the…”
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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression by Korhonen, Emilia A, Murtomaki, Aino, Jha, Sawan Kumar, Anisimov, Andrey, Pink, Anne, Zhang, Yan, Stritt, Simon, Liaqat, Inam, Stanczuk, Lukas, Alderfer, Laura, Sun, Zhiliang, Kapiainen, Emmi, Singh, Abhishek, Sultan, Ibrahim, Lantta, Anni, Leppanen, Veli-Matti, Eklund, Lauri, He, Yulong, Augustin, Hellmut G, Vaahtomeri, Kari, Saharinen, Pipsa, Makinen, Taija, Alitalo, Kari

“…Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in…”
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A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss by Stritt, Simon, Nurden, Paquita, Turro, Ernest, Greene, Daniel, Jansen, Sjoert B., Westbury, Sarah K., Petersen, Romina, Astle, William J., Marlin, Sandrine, Bariana, Tadbir K., Kostadima, Myrto, Lentaigne, Claire, Maiwald, Stephanie, Papadia, Sofia, Kelly, Anne M., Stephens, Jonathan C., Penkett, Christopher J., Ashford, Sofie, Tuna, Salih, Austin, Steve, Bakchoul, Tamam, Collins, Peter, Favier, Rémi, Lambert, Michele P., Mathias, Mary, Millar, Carolyn M., Mapeta, Rutendo, Perry, David J., Schulman, Sol, Simeoni, Ilenia, Thys, Chantal, Gomez, Keith, Erber, Wendy N., Stirrups, Kathleen, Rendon, Augusto, Bradley, John R., van Geet, Chris, Raymond, F.Lucy, Laffan, Michael A., Nurden, Alan T., Nieswandt, Bernhard, Richardson, Sylvia, Freson, Kathleen, Ouwehand, Willem H., Mumford, Andrew D.

“…Macrothrombocytopenia (MTP) is a heterogeneous group of disorders characterized by enlarged and reduced numbers of circulating platelets, sometimes resulting…”
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Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice by Stritt, Simon, Wolf, Karen, Lorenz, Viola, Vögtle, Timo, Gupta, Shuchi, Bösl, Michael R., Nieswandt, Bernhard

“…Platelet aggregation at sites of vascular injury is essential for hemostasis but also thrombosis. Platelet adhesiveness is critically dependent on…”
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Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels by Zhang, Yang, Daubel, Nina, Stritt, Simon, Mäkinen, Taija

“…Maintenance of blood vessel integrity is crucial for vascular homeostasis and is mainly controlled at the level of endothelial cell (EC) junctions. Regulation…”
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EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity by Frye, Maike, Stritt, Simon, Ortsäter, Henrik, Hernandez Vasquez, Magda, Kaakinen, Mika, Vicente, Andres, Wiseman, John, Eklund, Lauri, Martínez-Torrecuadrada, Jorge L, Vestweber, Dietmar, Mäkinen, Taija

“…Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the…”
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APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis by Stritt, Simon, Nurden, Paquita, Nurden, Alan T, Schved, Jean-François, Bordet, Jean-Claude, Roux, Maguelonne, Alessi, Marie-Christine, Trégouët, David-Alexandre, Mäkinen, Taija, Giansily-Blaizot, Muriel

“…Vascular homeostasis is impaired in various diseases thereby contributing to the progression of their underlying pathologies. The endothelial immediate early…”
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TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice by Gotru, Sanjeev K, Chen, Wenchun, Kraft, Peter, Becker, Isabelle C, Wolf, Karen, Stritt, Simon, Zierler, Susanna, Hermanns, Heike M, Rao, Deviyani, Perraud, Anne-Laure, Schmitz, Carsten, Zahedi, René P, Noy, Peter J, Tomlinson, Michael G, Dandekar, Thomas, Matsushita, Masayuki, Chubanov, Vladimir, Gudermann, Thomas, Stoll, Guido, Nieswandt, Bernhard, Braun, Attila

“…OBJECTIVE—TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient…”
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Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture by Stritt, Simon, Nurden, Paquita, Favier, Remi, Favier, Marie, Ferioli, Silvia, Gotru, Sanjeev K., van Eeuwijk, Judith M M., Schulze, Harald, Nurden, Alan T., Lambert, Michele P., Turro, Ernest, Burger-Stritt, Stephanie, Matsushita, Masayuki, Mittermeier, Lorenz, Ballerini, Paola, Zierler, Susanna, Laffan, Michael A., Chubanov, Vladimir, Gudermann, Thomas, Nieswandt, Bernhard, Braun, Attila

“…Mg 2+ plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms…”
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Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect by Bender, Markus, Stritt, Simon, Nurden, Paquita, van Eeuwijk, Judith M. M., Zieger, Barbara, Kentouche, Karim, Schulze, Harald, Morbach, Henner, Stegner, David, Heinze, Katrin G., Dütting, Sebastian, Gupta, Shuchi, Witke, Walter, Falet, Hervé, Fischer, Alain, Hartwig, John H., Nieswandt, Bernhard

“…Wiskott–Aldrich syndrome (WAS) is caused by mutations in the WAS gene and is characterized by immunodeficiency, eczema and microthrombocytopenia. The molecular…”
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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis by Dütting, Sebastian, Gaits-Iacovoni, Frederique, Stegner, David, Popp, Michael, Antkowiak, Adrien, van Eeuwijk, Judith M.M., Nurden, Paquita, Stritt, Simon, Heib, Tobias, Aurbach, Katja, Angay, Oguzhan, Cherpokova, Deya, Heinz, Niels, Baig, Ayesha A., Gorelashvili, Maximilian G., Gerner, Frank, Heinze, Katrin G., Ware, Jerry, Krohne, Georg, Ruggeri, Zaverio M., Nurden, Alan T., Schulze, Harald, Modlich, Ute, Pleines, Irina, Brakebusch, Cord, Nieswandt, Bernhard

“…Blood platelets are produced by large bone marrow (BM) precursor cells, megakaryocytes (MKs), which extend cytoplasmic protrusions (proplatelets) into BM…”
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Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization by Lorenz, Viola, Stegner, David, Stritt, Simon, Vögtle, Timo, Kiefer, Friedemann, Witke, Walter, Schymeinsky, Jürgen, Watson, Steve P., Walzog, Barbara, Nieswandt, Bernhard

“…Platelet aggregation at sites of vascular injury is not only essential for hemostasis, but may also cause acute ischemic disease states such as myocardial…”
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Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets by Scheller, Inga, Stritt, Simon, Beck, Sarah, Peng, Bing, Pleines, Irina, Heinze, Katrin G, Braun, Attila, Otto, Oliver, Ahrends, Robert, Sickmann, Albert, Bender, Markus, Nieswandt, Bernhard

“…Platelet aggregate formation is a multistep process involving receptor-mediated, as well as biomechanical, signaling cascades, which are highly dependent on…”
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Profilin 1–mediated cytoskeletal rearrangements regulate integrin function in mouse platelets by Stritt, Simon, Birkholz, Inga, Beck, Sarah, Sorrentino, Simona, Sapra, K. Tanuj, Viaud, Julien, Heck, Johannes, Gaits-Iacovoni, Frédérique, Schulze, Harald, Du, Xiaoping, Hartwig, John H., Braun, Attila, Bender, Markus, Medalia, Ohad, Nieswandt, Bernhard

“…•Profilin 1–mediated cytoskeletal dynamics regulate platelet β1- and β3-integrin function and turnover.•Profilin 1 deficiency in platelets impairs hemostasis…”
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Megakaryocyte rupture for acute platelet needs by Nieswandt, Bernhard, Stritt, Simon

“…Circulating platelets were thought to arise solely from the protrusion and fragmentation of megakaryocyte cytoplasm. Now, Nishimura et al. (2015. J. Cell Biol…”
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Megakaryocyte rupture for acute platelet needs by Nieswandt, Bernhard, Stritt, Simon

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In vitro platelets in sight by Stritt, Simon, Nieswandt, Bernhard

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Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation by Petkova, Milena, Kraft, Marle, Stritt, Simon, Martinez-Corral, Ines, Ortsäter, Henrik, Vanlandewijck, Michael, Jakic, Bojana, Baselga, Eulàlia, Castillo, Sandra D, Graupera, Mariona, Betsholtz, Christer, Mäkinen, Taija

“…Oncogenic mutations in PIK3CA, encoding p110α-PI3K, are a common cause of venous and lymphatic malformations. Vessel type-specific disease pathogenesis is…”
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MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice by Gotru, Sanjeev Kiran, Mammadova-Bach, Elmina, Sogkas, Georgios, Schuhmann, Michael K., Schmitt, Karen, Kraft, Peter, Herterich, Sabine, Mamtimin, Medina, Pinarci, Akif, Beck, Sarah, Stritt, Simon, Han, Chao, Ren, Pengxuan, Freund, Jean-Noël, Klemann, Christian, Ringshausen, Felix C., Heemskerk, Johan W.M., Dietrich, Alexander, Nieswandt, Bernhard, Stoll, Guido, Gudermann, Thomas, Braun, Attila

“…MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide protein complex with thiol-disulfide oxidoreductase activity, supporting the process of…”
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