Search Results - "Strindhall, Jan"

Cytomegalovirus and human immunosenescence by Pawelec, Graham, Derhovanessian, Evelyna, Larbi, Anis, Strindhall, Jan, Wikby, Anders

“…‘Immunosenescence’ is an imprecise term used to describe deleterious age‐associated changes to immune parameters observed in all mammals studied so far…”
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Immunosenescence and Cytomegalovirus: where do we stand after a decade? by Pawelec, Graham, Akbar, Arne, Beverley, Peter, Caruso, Calogero, Derhovanessian, Evelyna, Fülöp, Tamas, Griffiths, Paul, Grubeck-Loebenstein, Beatrix, Hamprecht, Klaus, Jahn, Gerhard, Kern, Florian, Koch, Sven D, Larbi, Anis, Maier, Andrea B, Macallan, Derek, Moss, Paul, Samson, Sandrine, Strindhall, Jan, Trannoy, Emanuelle, Wills, Mark

“…[...] an important question becomes whether the CMV-sensitive altered immune cell subset distributions in the elderly, particularly the decreased numbers and…”
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Report from the second cytomegalovirus and immunosenescence workshop by Wills, Mark, Akbar, Arne, Beswick, Mark, Bosch, Jos A, Caruso, Calogero, Colonna-Romano, Giuseppina, Dutta, Ambarish, Franceschi, Claudio, Fulop, Tamas, Gkrania-Klotsas, Effrossyni, Goronzy, Joerg, Griffiths, Stephen J, Henson, Sian, Herndler-Brandstetter, Dietmar, Hill, Ann, Kern, Florian, Klenerman, Paul, Macallan, Derek, Macualay, Richard, Maier, Andrea B, Mason, Gavin, Melzer, David, Morgan, Matthew, Moss, Paul, Nikolich-Zugich, Janko, Pachnio, Annette, Riddell, Natalie, Roberts, Ryan, Sansoni, Paolo, Sauce, Delphine, Sinclair, John, Solana, Rafael, Strindhall, Jan, Trzonkowski, Piotr, van Lier, Rene, Vescovini, Rosanna, Wang, George, Westendorp, Rudi, Pawelec, Graham

“…The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions:…”
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Cytomegalovirus Infection by KOCH, SVEN, LARBI, ANIS, ÖZCELIK, DENNIS, SOLANA, RAFAEL, GOUTTEFANGEAS, CÉCILE, ATTIG, SEBASTIAN, WIKBY, ANDERS, STRINDHALL, JAN, FRANCESCHI, CLAUDIO, PAWELEC, GRAHAM

“…:  The human immune system evolved to defend the organism against pathogens, but is clearly less well able to do so in the elderly, resulting in greater…”
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Cytomegalovirus infection: a driving force in human T cell immunosenescence by Koch, Sven, Larbi, Anis, Ozcelik, Dennis, Solana, Rafael, Gouttefangeas, Cécile, Attig, Sebastian, Wikby, Anders, Strindhall, Jan, Franceschi, Claudio, Pawelec, Graham

“…The human immune system evolved to defend the organism against pathogens, but is clearly less well able to do so in the elderly, resulting in greater morbidity…”
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Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly by Hadrup, Sine Reker, Strindhall, Jan, Kollgaard, Tania, Seremet, Tina, Johansson, Boo, Pawelec, Graham, thor Straten, Per, Wikby, Anders

“…The age-associated decrease in functionality of the human immune system is thought to have a negative impact on the capacity to provide protection against…”
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Role of N-linked glycosylation in expression of E-selectin on human endothelial cells by Påhlsson, P, Strindhall, J, Srinivas, U, Lundblad, A

“…E-selectin is a cytokine-inducible membrane glycoprotein capable of mediating adhesion of leukocytes to endothelial cells. It is highly glycosylated,…”
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The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20–100 years of age by Wikby, Anders, Månsson, Ingrid A., Johansson, Boo, Strindhall, Jan, Nilsson, Sven E.

“…Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86–94 years of age, characterised by an inverted CD4/CD8 ratio and associated with…”
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The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study by Strindhall, J., Skog, M., Ernerudh, J., Bengner, M., Löfgren, S., Matussek, A., Nilsson, B. O., Wikby, A.

“…The Swedish OCTO and NONA immune longitudinal studies were able to identify and confirm an immune risk profile (IRP) predictive of an increased 2-year…”
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An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans by Wikby, Anders, Ferguson, Frederick, Forsey, Rosalyn, Thompson, Julie, Strindhall, Jan, Löfgren, Sture, Nilsson, Bengt-Olof, Ernerudh, Jan, Pawelec, Graham, Johansson, Boo

“…In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also…”
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No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study by Strindhall, Jan, Nilsson, Bengt-Olof, Löfgren, Sture, Ernerudh, Jan, Pawelec, Graham, Johansson, Boo, Wikby, Anders

“…In the present NONA immune longitudinal study, we investigate the previously identified Immune Risk Profile (IRP), defined by an inverted CD4/CD8 ratio and…”
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The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning by Wikby, Anders, Nilsson, Bengt-Olof, Forsey, Rosalyn, Thompson, Julie, Strindhall, Jan, Löfgren, Sture, Ernerudh, Jan, Pawelec, Graham, Ferguson, Frederick, Johansson, Boo

“…In the present NONA immune longitudinal study, we further examine the previously identified T cell immune risk phenotype (IRP), relative inflammatory activity,…”
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Humoral response to influenza vaccination in relation to pre-vaccination antibody titres, vaccination history, cytomegalovirus serostatus and CD4/CD8 ratio by Strindhall, Jan, Ernerudh, Jan, Mörner, Andreas, Waalen, Kristian, Löfgren, Sture, Matussek, Andreas, Bengner, Malin

“…Background Annual vaccination against influenza virus is generally recommended to elderly and chronically ill, but the relative importance of factors…”
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CD4/CD8 ratio<1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-Year follow-up of the Swedish HEXA Immune Longitudinal Study by Strindhall, Jan, Löfgren, Sture, Främsth, Caroline, Matussek, Andreas, Bengner, Malin, Ernerudh, Jan, Wikby, Anders

“…•CD4/CD8 ratio<1, CMV IgG+ status and T cell repertoire and response are associated.•Changes over 5years for CD3+, CD4+, CD8+, CD19+ and CD4/CD8 ratio are…”
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CD4/CD8 ratio &lt; 1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-Year follow-up of the Swedish HEXA Immune Longitudinal Study by Strindhall, Jan, Löfgren, Sture, Främsth, Caroline, Matussek, Andreas, Bengner, Malin, Ernerudh, Jan, Wikby, Anders

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Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria by Rodhe, Nils, Löfgren, Sture, Strindhall, Jan, Matussek, Andreas, Mölstad, Sigvard

“…Objective. Searching for useful diagnostic tools to discriminate between asymptomatic bacteriuria (ASB) and acute cystitis, this study compared urinary levels…”
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Plasma cytokine profiles in elderly humans by Forsey, R.J., Thompson, J.M., Ernerudh, J., Hurst, T.L., Strindhall, J., Johansson, B., Nilsson, B.-O., Wikby, A.

“…It is known that as we age, immune dysregulation often occurs, leading to failing health, and increased susceptibility to a number of different diseases. In…”
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Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity by Bengnér, Malin, Béziat, Vivien, Ernerudh, Jan, Nilsson, Bengt-Olof, Löfgren, Sture, Wikby, Anders, Malmberg, Karl Johan, Strindhall, Jan

“…Cytomegalovirus (CMV) infection induces profound changes in different subsets of the cellular immune system. We have previously identified an immune risk…”
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Cytomegalovirus infection: a driving force in human T cell immunosenescence by Koch, Sven, Larbi, Anis, Ozcelik, Dennis, Solana, Rafael, Gouttefangeas, Cécile, Attig, Sebastian, Wikby, Anders, Strindhall, Jan, Franceschi, Claudio, Pawelec, Graham

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Infection of Human Endothelial Cells with Staphylococcus aureus Induces Transcription of Genes Encoding an Innate Immunity Response by Matussek, A., Strindhall, J., Stark, L., Rohde, M., Geffers, R., Buer, J., Kihlström, E., Lindgren, P.‐E., Löfgren, S.

“…Staphylococcus aureus is a gram‐positive bacterium frequently isolated from patients with bloodstream infections. Endothelial cells (EC) play an important role…”
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