Noninvasive monitoring of nonshunted pulmonary capillary blood flow in the acute respiratory distress syndrome

OBJECTIVE:Noninvasive monitoring of nonshunted pulmonary capillary blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome. DESIGN:Experimental animal study SETTING:University center for animal experiments INTERVENTIONS:In 12 m...

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Bibliographic Details
Published in:	Critical care medicine Vol. 28; no. 4; pp. 1059 - 1067
Main Authors:	Kanhai, Karan J. K, Strijdhorst, Henk, Pompe, Jan C, Holland, Wim P. J, Ong, Eveline G. J, Puppels, Gerwin J
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins, Inc 01-04-2000 Lippincott
Subjects:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bronchoalveolar Lavage Capillaries - physiopathology Cardiac Output - physiology Disease Models, Animal Emergency and intensive care: techniques, logistics Female Intensive care medicine Medical sciences Monitoring Monitoring, Physiologic - methods Monitoring, Physiologic - statistics & numerical data Positive-Pressure Respiration - methods Positive-Pressure Respiration - statistics & numerical data Pulmonary Circulation - physiology Respiratory Distress Syndrome, Adult - physiopathology Respiratory Distress Syndrome, Adult - therapy Swine Thermodilution Intensive care Respiratory disease Response amplitude Lung Expiration Artificial ventilation Blood flow Pig Vertebrata Mammalia Adult respiratory distress syndrome Positive pressure Measurement technique Animal Blood capillary Artiodactyla Hemodynamics Mechanical ventilation Ungulata Monitoring
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Summary:	OBJECTIVE:Noninvasive monitoring of nonshunted pulmonary capillary blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome. DESIGN:Experimental animal study SETTING:University center for animal experiments INTERVENTIONS:In 12 mechanically ventilated pigs, the nonshunted pulmonary capillary blood flow was varied by means of lung lavages and the application of positive end-expiratory pressure. MEASUREMENTS AND MAIN RESULTS:Nonshunted pulmonary capillary blood flow was determined by AART. Cardiac output (determined by the thermodilution method) corrected for venous admixture was used for comparison (r varied between .58 and .94; p < .01). The trend in the development of nonshunted pulmonary capillary blood flow as measured with AART was in agreement with the trend detected by cardiac output corrected for venous admixture in 92% of all events. CONCLUSIONS:We conclude that AART can be used to monitor changes in nonshunted pulmonary capillary blood flow in cases of acute respiratory distress syndrome noninvasively and continuously.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0090-3493 1530-0293
DOI:	10.1097/00003246-200004000-00025