Search Results - "Striessnig, J."

Neurobiology of migraine by Pietrobon, Daniela, Striessnig, Jörg

“…Migraine -- an episodic headache -- affects more than 10% of the general population. Despite recent progress, drug therapy for preventing and treating migraine…”
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Role of voltage-gated L-type Ca2+ channel isoforms for brain function by Striessnig, J, Koschak, A, Sinnegger-Brauns, M J, Hetzenauer, A, Nguyen, N K, Busquet, P, Pelster, G, Singewald, N

“…Voltage-gated LTCCs (L-type Ca2+ channels) are established drug targets for the treatment of cardiovascular diseases. LTCCs are also expressed outside the…”
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Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction by Whittle, N, Maurer, V, Murphy, C, Rainer, J, Bindreither, D, Hauschild, M, Scharinger, A, Oberhauser, M, Keil, T, Brehm, C, Valovka, T, Striessnig, J, Singewald, N

“…Extinction-based exposure therapy is used to treat anxiety- and trauma-related disorders; however, there is the need to improve its limited efficacy in…”
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Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy by Wolf, M, Eberhart, A, Glossmann, H, Striessnig, J, Grigorieff, N

“…The three-dimensional structure of the skeletal muscle voltage-gated L-type calcium channel (Ca(v)1.1; dihydropyridine receptor, DHPR) was determined using…”
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Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens by Martínez-Rivera, A, Hao, J, Tropea, T F, Giordano, T P, Kosovsky, M, Rice, R C, Lee, A, Huganir, R L, Striessnig, J, Addy, N A, Han, S, Rajadhyaksha, A M

“…Genetic factors significantly influence susceptibility for substance abuse and mood disorders. Rodent studies have begun to elucidate a role of Ca v 1.3 L-type…”
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Structural basis of drug binding to L Ca2+ channels by Striessnig, J, Grabner, M, Mitterdorfer, J, Hering, S, Sinnegger, M J, Glossmann, H

“…At least five different types of voltage-gated Ca2+ channels exist in electrically excitable mammalian cells. Only one type, the family of L-type Ca2+ channels…”
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Purification, Molecular Cloning, and Expression of the Mammalian sigma1-Binding Site by Hanner, Markus, Moebius, Fabian F., Flandorfer, Astrid, Knaus, Hans-Günther, Striessnig, Jörg, Kempner, Ellis, Glossmann, Hartmut

“…Sigma-ligands comprise several chemically unrelated drugs such as haloperidol, pentazocine, and ditolyl-guanidine, which bind to a family of low molecular mass…”
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Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes by Mangoni, Matteo E., Couette, Brigitte, Marger, Laurine, Bourinet, Emmanuel, Striessnig, Jörg, Nargeot, Joël

“…The spontaneous activity of pacemaker cells in the sino-atrial node controls the heart rhythm and rate under physiological conditions. Compared to working…”
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Role of class D L-type Ca2+ channels for cochlear morphology by GLUECKERT, R, WIETZORREK, G, KAMMEN-JOLLY, K, SCHOLTZ, A, STEPHAN, K, STRIESSNIG, J, SCHROTT-FISCHER, A

“…Voltage-gated Ca(2+) channels formed by subunits (class D Ca(2+) channels) tightly regulate neurotransmitter release from cochlear inner hair cells (IHCs) by…”
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Up‐regulation of dopamine D2L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine‐sensitized C57BL/6 mice: role of Cav1.3 L‐type Ca2+ channels by Giordano, T. P., Satpute, S. S., Striessnig, J., Kosofsky, B. E., Rajadhyaksha, A. M.

“…Dopamine D2 long (D2L) and D2 short (D2S) isoforms of the D2 receptor play an important role in psychostimulant‐induced neuronal adaptations. In this study, we…”
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Brain activation pattern induced by stimulation of L-type Ca2+-channels: Contribution of CaV1.3 and CaV1.2 isoforms by Hetzenauer, A., Sinnegger-Brauns, M.J., Striessnig, J., Singewald, N.

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Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit by Striessnig, J, Murphy, B J, Catterall, W A

“…To identify the binding domain for dihydropyridine Ca2+ antagonists, skeletal muscle Ca2+ channels were photolabeled with [3H](+)-PN200-110 and [3H]azidopine…”
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J019 Functional consequences of inactivation of L-type cav1.3 and T-type Cav3.1 channels on in vivo pacemaker activity and calcium cycling in cardiac automatic cells by Torrente, A, Mesirca, P, Fort, A, Neco, P, Gomez, A, Aptel, H, Striessnig, J, Nargeot, J, Mangoni, M.-E

“…Cardiac automaticity, in normal conditions, is generated by the Sinoatrial Node (SAN) tissue. In the last years, two pacemaker mechanisms are proposed: the…”
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Ligand-induced accelerated dissociation of (+)-cis-diltiazem from L-type Ca2+ channels is simply explained by competition for individual attachment points by Prinz, H., Striessnig, J.

“…We have studied the kinetics of (+)-[3H]cis-diltiazem binding to L-type Ca2+ channels. The association reaction was of the second order with a rate constant of…”
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Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine by Nakayama, H, Taki, M, Striessnig, J, Glossmann, H, Catterall, W A, Kanaoka, Y

“…To identify regions that are involved in the formation of the dihydropyridine receptor site of skeletal muscle L-type Ca2+ channels, the alpha 1 subunit of the…”
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J020 A functional role for Cav1.3 channels in muscarinic regulation of heart rate (HR) and automaticity in pacemaker cells: experimental results by Mesirca, P, Torrente, A, Marger, L, Fort, A, Cohen-Solal, A, Leoni, A.-L, Striessnig, J, Nargeot, J, Mangoni, M.-E

“…Aim To investigate the effects of different agonist for the muscarinic receptor on cardiac automaticity in Cav1.3-/-, Kir 3.4-/- and Cav1.3-/-Kir3.4-/- mice…”
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International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels by Catterall, William A, Perez-Reyes, Edward, Snutch, Terrance P, Striessnig, Joerg

“…The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local intracellular calcium…”
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Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers by Horak, Silja, Koschak, Alexandra, Stuppner, Hermann, Striessnig, Jörg

“…Migraine is a frequent and often disabling disease. Treatment is unsatisfactory in many patients. A disturbed dynamic balance between excitatory and inhibitory…”
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Molecular properties of calcium channels by Glossmann, H, Striessnig, J

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Calcium channels in mouse hair cells: function, properties and pharmacology by Engel, Jutta, Michna, Marcus, Platzer, Josef, Striessnig, Jörg

“…Adult inner hair cells (IHCs) possess voltage-activated Ca2+ currents that couple receptor potentials to transmitter release at the afferent synapses. Before…”
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