Search Results - "Strick, Terence R"

Direct observation of helicase–topoisomerase coupling within reverse gyrase by Yang, Xi, Garnier, Florence, Débat, Hélène, Strick, Terence R., Nadal, Marc

“…Reverse gyrases (RGs) are the only topoisomerases capable of generating positive supercoils in DNA. Members of the type IA family, they do so by generating a…”
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Dissection of DNA double-strand-break repair using novel single-molecule forceps by Wang, Jing L., Duboc, Camille, Wu, Qian, Ochi, Takashi, Liang, Shikang, Tsutakawa, Susan E., Lees-Miller, Susan P., Nadal, Marc, Tainer, John A., Blundell, Tom L., Strick, Terence R.

“…Repairing DNA double-strand breaks (DSBs) by nonhomologous end joining (NHEJ) requires multiple proteins to recognize and bind DNA ends, process them for…”
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Abortive Initiation and Productive Initiation by RNA Polymerase Involve DNA Scrunching by Revyakin, Andrey, Liu, Chenyu, Ebright, Richard H, Strick, Terence R

“…Using single-molecule DNA nanomanipulation, we show that abortive initiation involves DNA "scrunching"--in which RNA polymerase (RNAP) remains stationary and…”
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On the stability of stalled RNA polymerase and its removal by RapA by Portman, James R, Qayyum, M Zuhaib, Murakami, Katsuhiko S, Strick, Terence R

“…Abstract Stalling of the transcription elongation complex formed by DNA, RNA polymerase (RNAP) and RNA presents a serious obstacle to concurrent processes due…”
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A dynamic DNA-repair complex observed by correlative single-molecule nanomanipulation and fluorescence by Graves, Evan T, Duboc, Camille, Fan, Jun, Stransky, François, Leroux-Coyau, Mathieu, Strick, Terence R

“…Single-molecule imaging reveals how stalled Escherichia coli RNA polymerase is displaced by the superfamily 2 DNA translocase (SF2) repair factor Mfd to permit…”
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Single-molecule reconstruction of eukaryotic factor-dependent transcription termination by Xiong, Ying, Han, Weijing, Xu, Chunhua, Shi, Jing, Wang, Lisha, Jin, Taoli, Jia, Qi, Lu, Ying, Hu, Shuxin, Dou, Shuo-Xing, Lin, Wei, Strick, Terence R., Wang, Shuang, Li, Ming

“…Factor-dependent termination uses molecular motors to remodel transcription machineries, but the associated mechanisms, especially in eukaryotes, are poorly…”
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Mechanism of efficient double-strand break repair by a long non-coding RNA by Thapar, Roopa, Wang, Jing L, Hammel, Michal, Ye, Ruiqiong, Liang, Ke, Sun, Chengcao, Hnizda, Ales, Liang, Shikang, Maw, Su S, Lee, Linda, Villarreal, Heather, Forrester, Isaac, Fang, Shujuan, Tsai, Miaw-Sheue, Blundell, Tom L, Davis, Anthony J, Lin, Chunru, Lees-Miller, Susan P, Strick, Terence R, Tainer, John A

“…Abstract Mechanistic studies in DNA repair have focused on roles of multi-protein DNA complexes, so how long non-coding RNAs (lncRNAs) regulate DNA repair is…”
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The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair by Mardenborough, Yannicka S N, Nitsenko, Katerina, Laffeber, Charlie, Duboc, Camille, Sahin, Enes, Quessada-Vial, Audrey, Winterwerp, Herrie H K, Sixma, Titia K, Kanaar, Roland, Friedhoff, Peter, Strick, Terence R, Lebbink, Joyce H G

“…DNA mismatch repair (MMR) maintains genome stability through repair of DNA replication errors. In Escherichia coli, initiation of MMR involves recognition of…”
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The mechanism of variability in transcription start site selection by Yu, Libing, Winkelman, Jared T, Pukhrambam, Chirangini, Strick, Terence R, Nickels, Bryce E, Ebright, Richard H

“…During transcription initiation, RNA polymerase (RNAP) binds to promoter DNA, unwinds promoter DNA to form an RNAP-promoter open complex (RPo) containing a…”
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Real-Time Detection of Single-Molecule DNA Compaction by Condensin I by Strick, Terence R, Kawaguchi, Tatsuhiko, Hirano, Tatsuya

“…Background: Condensin is thought to contribute to large-scale DNA compaction during mitotic chromosome assembly. It remains unknown, however, how the complex…”
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Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination by Wang, Shuang, Han, Zhong, Strick, Terence R

“…Sen1 is an essential helicase for factor-dependent transcription termination in Saccharomyces cerevisiae, whose molecular-motor mechanism has not been well…”
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Promoter Unwinding and Promoter Clearance by RNA Polymerase: Detection by Single-Molecule DNA Nanomanipulation by Revyakin, Andrey, Ebright, Richard H., Strick, Terence R., Roberts, Jeffrey W.

“…By monitoring the end-to-end extension of a mechanically stretched, supercoiled, single DNA molecule, we have been able directly to observe the change in…”
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Single-molecule analysis of DNA uncoiling by a type II topoisomerase by Strick, Terence R, Croquette, Vincent, Bensimon, David

“…Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment…”
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Watching single molecules in action by Monnet, Jordan, Strick, Terence R

“…A fluorescent imaging technique called fastFISH has been used to track the various steps involved in the transcription of a single DNA molecule…”
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Molecular scaffolds: when DNA becomes the hardware for single-molecule investigations by Gosse, Charlie, Strick, Terence R., Kostrz, Dorota

“…Over the past few decades, single-molecule manipulation has been widely applied to the real-time analysis of biomolecular interactions. It has enabled…”
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A measure of force by Strick, Terence R., Yan, Jie

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Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation by Wang, Jinglong, Le Gall, Julien, Frock, Richard L., Strick, Terence R.

“…Using Sanger sequencing and high-throughput genome sequencing of DNA cleavage reactions, we find that the Streptococcus pyogenes SpCas9 complex responds to…”
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Author Correction: Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation by Wang, Jinglong, Le Gall, Julien, Frock, Richard L., Strick, Terence R.

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Reconstruction of bacterial transcription-coupled repair at single-molecule resolution by Fan, Jun, Leroux-Coyau, Mathieu, Savery, Nigel J., Strick, Terence R.

“…Single-molecule assays show that the recruitment of UvrA and UvrAB to Mfd–RNA polymerase complex formed on a DNA lesion arrests the translocating complex and…”
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Cotranscriptional R-loop formation by Mfd involves topological partitioning of DNA by Portman, James R., Brouwer, Gwendolyn M., Bollins, Jack, Savery, Nigel J., Strick, Terence R.

“…R-loops are nucleic acid hybrids which form when an RNA invades duplex DNA to pair with its template sequence. Although they are implicated in a growing number…”
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