Search Results - "Strick, Christine A."

Immunohistochemical Localization of Phosphodiesterase 10A in Multiple Mammalian Species by Coskran, Timothy M, Morton, Daniel, Menniti, Frank S, Adamowicz, Wendy O, Kleiman, Robin J, Ryan, Anne M, Strick, Christine A, Schmidt, Christopher J, Stephenson, Diane T

“…A monoclonal antibody directed against the amino terminal of rat phosphodiesterase 10A (PDE10A) was used to localize PDE10A in multiple central nervous system…”
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Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Fujiwara, Remie A., James, Larry C., Williams, Robert D., Stock, Jeffrey L., McNeish, John D., Strick, Christine A., Menniti, Frank S., Schmidt, Christopher J.

“…PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the…”
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Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors by Duplantier, Allen J, Becker, Stacey L, Bohanon, Michael J, Borzilleri, Kris A, Chrunyk, Boris A, Downs, James T, Hu, Lain-Yen, El-Kattan, Ayman, James, Larry C, Liu, Shenping, Lu, Jiemin, Maklad, Noha, Mansour, Mahmoud N, Mente, Scot, Piotrowski, Mary A, Sakya, Subas M, Sheehan, Susan, Steyn, Stefanus J, Strick, Christine A, Williams, Victoria A, Zhang, Lei

“…3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding…”
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Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice by Rais, Rana, Thomas, Ajit G, Wozniak, Krystyna, Wu, Ying, Jaaro-Peled, Hanna, Sawa, Akira, Strick, Christine A, Engle, Sandra J, Brandon, Nicholas J, Rojas, Camilo, Slusher, Barbara S, Tsukamoto, Takashi

“…D-Amino acid oxidase (DAAO) catalyzes the oxidative deamination of D-amino acids including D-serine, a full agonist at the glycine modulatory site of the…”
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Immunohistochemical localization of PDE10A in the rat brain by Seeger, Thomas F, Bartlett, Brenda, Coskran, Timothy M, Culp, Jeffrey S, James, Larry C, Krull, David L, Lanfear, Jerry, Ryan, Anne M, Schmidt, Christopher J, Strick, Christine A, Varghese, Alison H, Williams, Robert D, Wylie, Patricia G, Menniti, Frank S

“…PDE10A is a newly identified cAMP/cGMP phosphodiesterase for which mRNA is highly expressed in the mammalian striatum. In the present study, PDE10A protein and…”
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Alterations in gene regulation following inhibition of the striatum-enriched phosphodiesterase, PDE10A by Strick, Christine A., James, Larry C., Fox, Carol B., Seeger, Thomas F., Menniti, Frank S., Schmidt, Christopher J.

“…PDE10A is a member of the phosphodiesterase superfamily highly enriched within medium spiny neurons (MSN) in mammalian striatum. We have used inhibitors of…”
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Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia by Dounay, Amy B, Anderson, Marie, Bechle, Bruce M, Campbell, Brian M, Claffey, Michelle M, Evdokimov, Artem, Evrard, Edelweiss, Fonseca, Kari R, Gan, Xinmin, Ghosh, Somraj, Hayward, Matthew M, Horner, Weldon, Kim, Ji-Young, McAllister, Laura A, Pandit, Jayvardhan, Paradis, Vanessa, Parikh, Vinod D, Reese, Matthew R, Rong, SuoBao, Salafia, Michelle A, Schuyten, Katherine, Strick, Christine A, Tuttle, Jamison B, Valentine, James, Wang, Hong, Zawadzke, Laura E, Verhoest, Patrick R

“…Kynurenine aminotransferase (KAT) II has been identified as a potential new target for the treatment of cognitive impairment associated with schizophrenia and…”
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Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain by Strick, Christine A., Li, Cheryl, Scott, Liam, Harvey, Brian, Hajós, Mihály, Steyn, Stefanus J., Piotrowski, Mary A., James, Larry C., Downs, James T., Rago, Brian, Becker, Stacey L., El-Kattan, Ayman, Xu, Youfen, Ganong, Alan H., Tingley, F. David, Ramirez, Andres D., Seymour, Patricia A., Guanowsky, Victor, Majchrzak, Mark J., Fox, Carol B., Schmidt, Christopher J., Duplantier, Allen J.

“…Observations that N-Methyl- d-Aspartate (NMDA) antagonists produce symptoms in humans that are similar to those seen in schizophrenia have led to the current…”
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Reduction of brain kynurenic acid improves cognitive function by Kozak, Rouba, Campbell, Brian M, Strick, Christine A, Horner, Weldon, Hoffmann, William E, Kiss, Tamas, Chapin, Douglas S, McGinnis, Dina, Abbott, Amanda L, Roberts, Brooke M, Fonseca, Kari, Guanowsky, Victor, Young, Damon A, Seymour, Patricia A, Dounay, Amy, Hajos, Mihaly, Williams, Graham V, Castner, Stacy A

“…The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate hypofunction, including…”
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Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition by Chang, Cheng, Fonseca, Kari R, Li, Cheryl, Horner, Weldon, Zawadzke, Laura E, Salafia, Michelle A, Welch, Kathryn A, Strick, Christine A, Campbell, Brian M, Gernhardt, Steve S, Rong, Haojing, Sawant-Basak, Aarti, Liras, Jennifer, Dounay, Amy, Tuttle, Jamison B, Verhoest, Patrick, Maurer, Tristan S

“…Kynurenic acid (KYNA) plays a significant role in maintaining normal brain function, and abnormalities in KYNA levels have been associated with various central…”
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Engineering Autoactivating Forms of Matrix Metalloproteinase-9 and Expression of the Active Enzyme in Cultured Cells and Transgenic Mouse Brain by Fisher, Katherine E, Fei, Qing, Laird, Ellen R, Stock, Jeffrey L, Allen, Melanie R, Sahagan, Barbara G, Strick, Christine A

“…Matrix metalloproteinases (MMPs) are hypothesized to play an important role in the pathogenesis of several central nervous system disorders. Increased levels…”
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Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions by Tuttle, Jamison B, Anderson, Marie, Bechle, Bruce M, Campbell, Brian M, Chang, Cheng, Dounay, Amy B, Evrard, Edelweiss, Fonseca, Kari R, Gan, Xinmin, Ghosh, Somraj, Horner, Weldon, James, Larry C, Kim, Ji-Young, McAllister, Laura A, Pandit, Jayvardhan, Parikh, Vinod D, Rago, Brian J, Salafia, Michelle A, Strick, Christine A, Zawadzke, Laura E, Verhoest, Patrick R

“…A series of aryl hydroxamates recently have been disclosed as irreversible inhibitors of kynurenine amino transferase II (KAT II), an enzyme that may play a…”
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Expression of rat I-TAC/CXCL11/SCYA11 during central nervous system inflammation: comparison with other CXCR3 ligands by McColl, Shaun R, Mahalingam, Surendran, Staykova, Maria, Tylaska, Laurie A, Fisher, Katherine E, Strick, Christine A, Gladue, Ronald P, Neote, Kuldeep S, Willenborg, David O

“…The chemokines are a large gene superfamily with critical roles in development and immunity. The chemokine receptor CXCR3 appears to play a major role in the…”
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Expression and Characterization of Canine Cytochrome P450 2D15 by Roussel, Fabienne, Duignan, David B., Lawton, Michael P., Obach, R.Scott, Strick, Christine A., Tweedie, Donald J.

“…CYP2D15 is the canine ortholog of human CYP2D6, the human CYP2D isoform involved in the metabolism of drugs such as antiarhythmics, adrenoceptor antagonists,…”
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Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 by Cole, K E, Strick, C A, Paradis, T J, Ogborne, K T, Loetscher, M, Gladue, R P, Lin, W, Boyd, J G, Moser, B, Wood, D E, Sahagan, B G, Neote, K

“…Chemokines are essential mediators of normal leukocyte trafficking as well as of leukocyte recruitment during inflammation. We describe here a novel non-ELR…”
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Treating neuropsychiatric disorders with PDE10A inhibitors by Siuciak, Judith A., Strick, Christine A.

“…Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of…”
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Translational Regulation of Mitochondrial Gene Expression by Nuclear Genes of Saccharomyces cerevisiae by Fox, T. D., Costanzo, Maria C., Strick, Christine A., Marykwas, Donna L., Seaver, Elaine C., Rosenthal, Janet K.

“…We describe several yeast nuclear mutations that specifically block expression of the mitochondrial genes encoding cytochrome c oxidase subunits II (COXII) and…”
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Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection by BERGERON, J, AMMIRATI, M, DANLEY, D, JAMES, L, NORCIA, M, RETSEMA, J, STRICK, C. A, SU, W.-G, SUTCLIFFE, J, WONDRACK, L

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Saccharomyces cerevisiae Positive Regulatory Gene PET111 Encodes a Mitochondrial Protein That Is Translated from an mRNA with a Long 5′ Leader by Strick, Christine A., Fox, Thomas D.

“…The yeast nuclear gene PET111 is required specifically for translation of the mitochondrion-coded mRNA for cytochrome c oxidase subunit II. We have determined…”
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Isolation and characterization of biologically active murine interleukin-6 produced in Escherichia coli by Grenett, H E, Danley, D E, Strick, C A, James, L C, Otterness, I G, Fuentes, N, Nesbitt, J E, Fuller, G M

“…Interleukin-6 (IL-6) is a multi-functional cytokine produced and secreted by several different cell types, including those of the immune system. A cDNA coding…”
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