Search Results - "Stricher, Francois"

A graphical interface for the FoldX forcefield by VAN DURME, Joost, DELGADO, Javier, STRICHER, Francois, SERRANO, Luis, SCHYMKOWITZ, Joost, ROUSSEAU, Frederic

“…A graphical user interface for the FoldX protein design program has been developed as a plugin for the YASARA molecular graphics suite. The most prominent…”
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How protein stability and new functions trade off by Tokuriki, Nobuhiko, Stricher, Francois, Serrano, Luis, Tawfik, Dan S

“…Numerous studies have noted that the evolution of new enzymatic specificities is accompanied by loss of the protein's thermodynamic stability (DeltaDeltaG),…”
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PepX: a structural database of non-redundant protein-peptide complexes by Vanhee, Peter, Reumers, Joke, Stricher, Francois, Baeten, Lies, Serrano, Luis, Schymkowitz, Joost, Rousseau, Frederic

“…Although protein-peptide interactions are estimated to constitute up to 40% of all protein interactions, relatively little information is available for the…”
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Prediction of Water and Metal Binding Sites and Their Affinities by Using the Fold-X Force Field by Joost W. H. Schymkowitz, Rousseau, Frederic, Martins, Ivo C., Ferkinghoff-Borg, Jesper, Stricher, Francois, Serrano, Luis, Fersht, Alan R.

“…The empirical force field Fold-X was developed previously to allow rapid free energy calculations in proteins. Here, we present an enhanced version of the…”
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BriX: a database of protein building blocks for structural analysis, modeling and design by Vanhee, Peter, Verschueren, Erik, Baeten, Lies, Stricher, Francois, Serrano, Luis, Rousseau, Frederic, Schymkowitz, Joost

“…High-resolution structures of proteins remain the most valuable source for understanding their function in the cell and provide leads for drug design. Since…”
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Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases by Blanco, Francisco J, Prieto, Jesús, Arnould, Sylvain, Daboussi, Fayza, Redondo, Pilar, Perez, Christophe, Muñoz, Inés G, Duchateau, Philippe, Pâques, Frédéric, Alibés, Andreu, Montoya, Guillermo, Stricher, Francois, Serrano, Luis, Cabaniols, Jean-Pierre

“…Xeroderma pigmentosum is a monogenic disease characterized by hypersensitivity to ultraviolet light. The cells of xeroderma pigmentosum patients are defective…”
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Protein-Peptide Interactions Adopt the Same Structural Motifs as Monomeric Protein Folds by Vanhee, Peter, Stricher, Francois, Baeten, Lies, Verschueren, Erik, Lenaerts, Tom, Serrano, Luis, Rousseau, Frederic, Schymkowitz, Joost

“…We compared the modes of interaction between protein-peptide interfaces and those observed within monomeric proteins and found surprisingly few differences…”
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HSPA8/HSC70 chaperone protein: Structure, function, and chemical targeting by Stricher, François, Macri, Christophe, Ruff, Marc, Muller, Sylviane

“…HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many…”
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Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production by Saaret, Annica, Villiers, Benoît, Stricher, François, Anissimova, Macha, Cadillon, Mélodie, Spiess, Reynard, Hay, Sam, Leys, David

“…Isobutene is a high value gaseous alkene used as fuel additive and a chemical building block. As an alternative to fossil fuel derived isobutene, we here…”
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Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm by Sánchez, Ignacio E, Beltrao, Pedro, Stricher, Francois, Schymkowitz, Joost, Ferkinghoff-Borg, Jesper, Rousseau, Frederic, Serrano, Luis

“…Current experiments likely cover only a fraction of all protein-protein interactions. Here, we developed a method to predict SH2-mediated protein-protein…”
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Modeling protein-peptide interactions using protein fragments: fitting the pieces? by Vanhee, Peter, Stricher, Francois, Baeten, Lies, Verschueren, Erik, Serrano, Luis, Rousseau, Frederic, Schymkowitz, Joost

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Analysis of Disease-Linked Rhodopsin Mutations Based on Structure, Function, and Protein Stability Calculations by Rakoczy, Elizabeth P., Kiel, Christina, McKeone, Richard, Stricher, François, Serrano, Luis

“…Retinitis pigmentosa (RP) refers to a heterogeneous group of inherited diseases that result in progressive retinal degeneration, characterized by visual field…”
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Quantifying information transfer by protein domains: analysis of the Fyn SH2 domain structure by Lenaerts, Tom, Ferkinghoff-Borg, Jesper, Stricher, Francois, Serrano, Luis, Schymkowitz, Joost W H, Rousseau, Frederic

“…Efficient communication between distant sites within a protein is essential for cooperative biological response. Although often associated with large…”
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E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer by Simões-Correia, Joana, Figueiredo, Joana, Lopes, Rui, Stricher, François, Oliveira, Carla, Serrano, Luis, Seruca, Raquel

“…E-cadherin is critical for the maintenance of tissue architecture due to its role in cell-cell adhesion. E-cadherin mutations are the genetic cause of…”
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Production of unstable proteins through the formation of stable core complexes by Levy, Nicolas, Eiler, Sylvia, Pradeau-Aubreton, Karine, Maillot, Benoit, Stricher, François, Ruff, Marc

“…Purification of proteins that participate in large transient complexes is impeded by low amounts, heterogeneity, instability and poor solubility. To circumvent…”
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Predicted Effects of Missense Mutations on Native-State Stability Account for Phenotypic Outcome in Phenylketonuria, a Paradigm of Misfolding Diseases by Pey, Angel L., Stricher, François, Serrano, Luis, Martinez, Aurora

“…Phenylketonuria (PKU) is a genetic disease caused by mutations in human phenylalanine hydroxylase (PAH). Most missense mutations result in misfolding of PAH,…”
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Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example by Alibés, Andreu, Nadra, Alejandro D, De Masi, Federico, Bulyk, Martha L, Serrano, Luis, Stricher, François

“…Quite often a single or a combination of protein mutations is linked to specific diseases. However, distinguishing from sequence information which mutations…”
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Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus by Muñoz, Inés G, Prieto, Jesús, Subramanian, Sunita, Coloma, Javier, Redondo, Pilar, Villate, Maider, Merino, Nekane, Marenchino, Marco, D'Abramo, Marco, Gervasio, Francesco L, Grizot, Sylvestre, Daboussi, Fayza, Smith, Julianne, Chion-Sotinel, Isabelle, Pâques, Frédéric, Duchateau, Philippe, Alibés, Andreu, Stricher, François, Serrano, Luis, Blanco, Francisco J, Montoya, Guillermo

“…Homing endonucleases recognize long target DNA sequences generating an accurate double-strand break that promotes gene targeting through homologous…”
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The Stability Effects of Protein Mutations Appear to be Universally Distributed by Tokuriki, Nobuhiko, Stricher, Francois, Schymkowitz, Joost, Serrano, Luis, Tawfik, Dan S.

“…How the thermodynamic stability effects of protein mutations (ΔΔ G) are distributed is a fundamental property related to the architecture, tolerance to…”
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Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences by Fajardo-Sanchez, Emmanuel, Stricher, François, Pâques, Frédéric, Isalan, Mark, Serrano, Luis

“…Meganucleases cut long (>12 bp) unique sequences in genomes and can be used to induce targeted genome engineering by homologous recombination in the vicinity…”
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