Search Results - "Stribling, D. Sloan"

Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice by Shearman, Lauren P, Wang, Sheng-Ping, Helmling, Steffen, Stribling, D. Sloan, Mazur, Paul, Ge, Lan, Wang, Liyang, Klussmann, Sven, Macintyre, D. Euan, Howard, Andrew D, Strack, Alison M

“…Ghrelin, an acylated peptide secreted from the stomach, acts as a short-term signal of nutrient depletion. Ghrelin is an endogenous ligand for the GH…”
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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats by Shearman, Lauren P., Camacho, Ramon E., Sloan Stribling, D., Zhou, Dan, Bednarek, Maria A., Hreniuk, Donna L., Feighner, Scott D., Tan, Carina P., Howard, Andrew D., Van der Ploeg, Lex H.T., MacIntyre, D.Euan, Hickey, Gerard J., Strack, Alison M.

“…Central administration of the neuropeptide melanin-concentrating hormone (MCH) stimulates feeding in rodents. We studied the effects of intracerebroventricular…”
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Furo[2,3- b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1 by Debenham, John S., Madsen-Duggan, Christina B., Toupence, Richard B., Walsh, Thomas F., Wang, Junying, Tong, Xinchun, Kumar, Sanjeev, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Feng, Yue, Marsh, Donald J., Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T.

“…The synthesis, SAR and binding affinities of cannabinoid-1 receptor (CB1R) inverse agonists based on furo[2,3- b]pyridine scaffolds are described. Food intake,…”
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Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation by Debenham, John S., Madsen-Duggan, Christina B., Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Schaeffer, Marie-Therese, Xiao, Jing Chen, Huang, Cathy C.R.-R., Shen, Chun-Pyn, Sloan Stribling, D., Shearman, Lauren P., Strack, Alison M., Euan MacIntyre, D., Hale, Jeffrey J., Walsh, Thomas F.

“…The synthesis, SAR and binding affinities are described for cannabinoid-1 receptor (CB1R) specific inverse agonists based on pyridopyrimidine and…”
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The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity by Tizzano, Joseph P, Stribling, D Sloan, Perez-Tilve, Diego, Strack, Alison, Frassetto, Andrea, Chen, Richard Z, Fong, Tung M, Shearman, Lauren, Krieter, Philip A, Tschöp, Matthias H, Skolnick, Phil, Basile, Anthony S

“…Selective inhibitors of biogenic amine (e.g., serotonin, norepinephrine, and dopamine) uptake exhibit varying degrees of safety and efficacy as antiobesity…”
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Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists by Meurer, Laura C., Finke, Paul E., Mills, Sander G., Walsh, Thomas F., Toupence, Richard B., Goulet, Mark T., Wang, Junying, Tong, Xinchun, Fong, Tung M., Lao, Julie, Schaeffer, Marie-Therese, Chen, Jing, Shen, Chun-Pyn, Sloan Stribling, D., Shearman, Lauren P., Strack, Alison M., Van der Ploeg, Lex H.T.

“…The synthesis and structure–activity relationships for four series of pyridine-based human CB1 inverse agonists are described. Structure–activity relationship…”
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Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents by SHEARMAN, Lauren P, SLOAN STRIBLING, D, SPANN, Stephanie K, MACNEIL, Douglas J, FONG, Tung M, METZGER, Joseph M, GOULET, Mark T, HAGMANN, William K, PLUMMER, Christopher W, FINKE, Paul E, MILLS, Sander G, SHAH, Shrenik K, CAMACHO, Ramon E, TRUONG, Quang, VAN DER PLOEG, L. H. T, EUAN MACINTYRE, D, STRACK, Alison M, ROSKO, Kimberly M, JUNYING WANG, TONG, Sharon, YUE FENG, MARSH, Donald J, HONG YU, XIAOMING GUAN

“…We document in vitro and in vivo effects of a novel, selective cannabinoid CB(1) receptor inverse agonist, Imidazole 24b…”
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Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists by Armstrong, Helen E., Galka, Amy, Lin, Linus S., Lanza, Thomas J., Jewell, James P., Shah, Shrenik K., Guthikonda, Ravi, Truong, Quang, Chang, Linda L., Quaker, Grace, Colandrea, Vincent J., Tong, Xinchun, Wang, Junying, Xu, Sherry, Fong, Tung M., Shen, Chun-Pyn, Lao, Julie, Chen, Jing, Shearman, Lauren P., Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Ha, Sookhee, der Ploeg, Lex Van, Goulet, Mark T., Hagmann, William K.

“…Sulfonamide analogues of the potent CB1R inverse agonist 2 (Taranabant) were optimized for CB1R activity. Sulfonamide analogues of the potent CB1R inverse…”
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Protein kinase C beta II specifically binds to and is activated by F-actin by Blobe, G C, Stribling, D S, Fabbro, D, Stabel, S, Hannun, Y A

“…The two most closely related isoenzymes of protein kinase C (PKC), PKC betaI and betaII, are distinct but highly homologous isoenzymes derived via alternative…”
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Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists by Madsen-Duggan, Christina B., Debenham, John S., Walsh, Thomas F., Toupence, Richard B., Huang, Song X., Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Schaeffer, Marie-Therese, Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Goulet, Mark T.

“…The synthesis and biological optimization for 5,6-diarylpyridines as CB1 receptor inverse agonists is described. Optimization of the biological activity for…”
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Discovery of N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity by Yan, Lin, Huo, Pei, Debenham, John S, Madsen-Duggan, Christina B, Lao, Julie, Chen, Richard Z, Xiao, Jing Chen, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P, Strack, Alison M, Tsou, Nancy, Ball, Richard G, Wang, Junying, Tong, Xinchun, Bateman, Thomas J, Reddy, Vijay B. G, Fong, Tung M, Hale, Jeffrey J

“…This paper describes the discovery of…”
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Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation by Madsen-Duggan, Christina B., Debenham, John S., Walsh, Thomas F., Yan, Lin, Huo, Pei, Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Stribling, D.Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T., Hale, Jeffrey J.

“…Synthesis and structure–activity relationships of cannabinoid-1 receptor (CB1R) inverse agonists based on dihydro-pyrano[2,3-b] pyridine and…”
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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity by Lin, Linus S, Lanza, Thomas J, Jewell, James P, Liu, Ping, Shah, Shrenik K, Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Xiao, Jing Chen, Shearman, Lauren P, Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Marsh, Donald J, Feng, Yue, Kumar, Sanjeev, Samuel, Koppara, Yin, Wenji, Van der Ploeg, Lex H. T, Goulet, Mark T, Hagmann, William K

“…The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in…”
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Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists by Plummer, Christopher W., Finke, Paul E., Mills, Sander G., Wang, Junying, Tong, Xinchun, Doss, George A., Fong, Tung M., Lao, Julie Z., Schaeffer, Marie-Therese, Chen, Jing, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Van der Ploeg, Lex H.T.

“…The synthesis and structure–activity relationships for a series of substituted 4,5-diphenylimidazole-2-carboxamide derivatives 2b as selective, orally active…”
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Regulation of Receptor-mediated Protein Kinase C Membrane Trafficking by Autophosphorylation by Feng, Xiao, Becker, Kevin P., Stribling, Sloan D., Peters, Kevin G., Hannun, Yusuf A.

“…Signal transduction via protein kinase C (PKC) is closely regulated by its subcellular localization. In response to activation of cell-surface receptors, PKC…”
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Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists by Debenham, John S., Madsen-Duggan, Christina B., Walsh, Thomas F., Wang, Junying, Tong, Xinchun, Doss, George A., Lao, Julie, Fong, Tung M., Schaeffer, Marie-Therese, Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Feng, Yue, Marsh, Donald J., Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Goulet, Mark T.

“…The synthesis, structure–activity relationship, and biological evaluation of a new class of 1,8-naphthyridinone CB1 receptor specific inverse agonists are…”
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Discovery of N -[(4 R )-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2 H -pyrano[2,3- b ]pyridin-4-yl]-5-methyl-1 H -pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity by Yan, Lin, Huo, Pei, Debenham, John S., Madsen-Duggan, Christina B., Lao, Julie, Chen, Richard Z., Xiao, Jing Chen, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Tsou, Nancy, Ball, Richard G., Wang, Junying, Tong, Xinchun, Bateman, Thomas J., Reddy, Vijay B. G., Fong, Tung M., Hale, Jeffrey J.

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Characterization of a novel and selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b, in rodents by Shearman, Lauren P., Stribling, D. Sloan, Camacho, Ramon E., Rosko, Kimberly M., Wang, Junying, Tong, Sharon, Feng, Yue, Marsh, Donald J., Yu, Hong, Guan, Xiaoming, Spann, Stephanie K., MacNeil, Douglas J., Fong, Tung M., Metzger, Joseph M., Goulet, Mark T., Hagmann, William K., Plummer, Christopher W., Finke, Paul E., Mills, Sander G., Shah, Shrenik K., Truong, Quang, Van der Ploeg, L.H.T., MacIntyre, D. Euan, Strack, Alison M.

“…We document in vitro and in vivo effects of a novel, selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b (5-(4-chlorophenyl)-…”
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Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents by Fong, Tung M, Guan, Xiao-Ming, Marsh, Donald J, Shen, Chun-Pyn, Stribling, D Sloan, Rosko, Kim M, Lao, Julie, Yu, Hong, Feng, Yue, Xiao, Jing C, Van der Ploeg, Lex H T, Goulet, Mark T, Hagmann, Williams K, Lin, Linus S, Lanza, Jr, Thomas J, Jewell, James P, Liu, Ping, Shah, Shrenik K, Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S, Francis, Barbara, Strack, Alison M, MacIntyre, D Euan, Shearman, Lauren P

“…The cannabinoid-1 receptor (CB1R) has been implicated in the control of energy balance. To explore the pharmacological utility of CB1R inhibition for the…”
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Corrigendum to “Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists”: [Bioorg. Med. Chem. Lett. 15 (2005) 645] by Meurer, Laura C., Finke, Paul E., Mills, Sander G., Walsh, Thomas F., Toupence, Richard B., Debenham, John S., Goulet, Mark T., Wang, Junying, Tong, Xinchun, Fong, Tung M., Lao, Julie, Schaeffer, Marie-Therese, Chen, Jing, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Van der Ploeg, Lex H.T.

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