Search Results - "Streuli, Michel"

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy by Binnewies, Mikhail, Pollack, Joshua L., Rudolph, Joshua, Dash, Subhadra, Abushawish, Marwan, Lee, Tian, Jahchan, Nadine S., Canaday, Pamela, Lu, Erick, Norng, Manith, Mankikar, Shilpa, Liu, Victoria M., Du, Xiaoyan, Chen, Amanda, Mehta, Ranna, Palmer, Rachael, Juric, Vladislava, Liang, Linda, Baker, Kevin P., Reyno, Leonard, Krummel, Matthew F., Streuli, Michel, Sriram, Venkataraman

“…Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms. We identify TREM2+…”
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The 193-kD Vault Protein, VPARP, Is a Novel Poly(ADP-Ribose) Polymerase by Kickhoefer, Valerie A., Siva, Amara C., Kedersha, Nancy L., Inman, Elisabeth M., Ruland, Cristina, Streuli, Michel, Rome, Leonard H.

“…Mammalian vaults are ribonucleoprotein (RNP) complexes, composed of a small ribonucleic acid and three proteins of 100, 193, and 240 kD in size. The 100-kD…”
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Liprins, a Family of LAR Transmembrane Protein-tyrosine Phosphatase-interacting Proteins by Serra-Pages, C, Medley, Q G, Tang, May, Hart, A, Streuli, M

“…LAR family transmembrane protein-tyrosine phosphatases function in axon guidance and mammary gland development. In cultured cells, LAR binds to the…”
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Skeletal Muscle Deformity and Neuronal Disorder in Trio Exchange Factor-Deficient Mouse Embryos by O'Brien, Stephen P., Seipel, Katja, Medley, Quintus G., Bronson, Roderick, Segal, Rosalind, Streuli, Michel

“…Dbl-homology guanine nucleotide exchange factors (DH-GEFs) regulate actin cytoskeletal reorganization, cell adhesion, and gene transcription via activation of…”
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RNA-Binding Protein TIAR is Essential for Primordial Germ Cell Development by Andreas R. P. Beck, Miller, Ira J., Anderson, Paul, Streuli, Michel

“…Primordial germ cells (PGCs) give rise to both eggs and sperm via complex maturational processes that require both cell migration and proliferation. However,…”
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Signaling between Focal Adhesion Kinase and Trio by Medley, Quintus G, Buchbinder, Elizabeth G, Tachibana, Kouichi, Ngo, Hai, Serra-Pagès, Carles, Streuli, Michel

“…The Trio guanine nucleotide exchange factor functions in neural development in Caenorhabditis elegans and Drosophila and in the development of neural tissues…”
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A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells by Tian, Q, Streuli, M, Saito, H, Schlossman, S F, Anderson, P

“…Cytolytic lymphocytes (CTLs) are characterized by their inclusion of cytoplasmic granules containing effector molecules such as perforin and the serine…”
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Trp56 of Rac1 Specifies Interaction with a Subset of Guanine Nucleotide Exchange Factors by Gao, Yuan, Xing, Jingchuan, Streuli, Michel, Leto, Thomas L., Zheng, Yi

“…Signaling specificity of Rho GTPase pathways is achieved in part by selective interaction between members of the Dbl family guanine nucleotide exchange factors…”
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Protein tyrosine phosphatases in signaling by Streuli, Michel

“…During the past few years, molecular cloning has established the existence of a structurally diverse family of intracellular and transmembrane protein tyrosine…”
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The Trio Guanine Nucleotide Exchange Factor Is a RhoA Target by Medley, Quintus G., Serra-Pagès, Carles, Iannotti, Elizabeth, Seipel, Katja, Tang, May, O'Brien, Stephen P., Streuli, Michel

“…Trio is a complex protein containing two guanine nucleotide exchange factor domains each with associated pleckstrin homology domains, a serine/threonine kinase…”
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Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab by Hutchins, Beth, Starling, Gary C, McCoy, Mark A, Herzyk, Danuta, Poulet, Frederique M, Dulos, John, Liu, Liming, Kang, Soonmo Peter, Fayadat-Dilman, Laurence, Hsieh, Mark, Andrews, Christine L, Ayanoglu, Gulesi, Cullen, Constance, Malefyt, Rene de Waal, Kastelein, Robert A, Saux, Sabine Le, Lee, Julie, Li, Sophie, Malashock, Dan, Sadekova, Svetlana, Soder, George, van Eenennaam, Hans, Willingham, Aarron, Yu, Ying, Streuli, Michel, Carven, Gregory J, van Elsas, Andrea

“…The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active…”
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TIA-1 is a translational silencer that selectively regulates the expression of TNF-α by Piecyk, Monica, Wax, Stephen, Beck, Andreas R.P., Kedersha, Nancy, Gupta, Mita, Maritim, Beatrice, Chen, Samantha, Gueydan, Cyril, Kruys, Veronique, Streuli, Michel, Anderson, Paul

“…TIA‐1 and TIAR are related proteins that bind to an AU‐rich element (ARE) in the 3′ untranslated region of tumor necrosis factor alpha (TNF‐α) transcripts. To…”
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Interaction between GRIP and Liprin-α/SYD2 Is Required for AMPA Receptor Targeting by Wyszynski, Michael, Kim, Eunjoon, Dunah, Anthone W., Passafaro, Maria, Valtschanoff, Juli G., Serra-Pagès, Carles, Streuli, Michel, Weinberg, Richard J., Sheng, Morgan

“…Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that…”
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Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha by Shin, Hyewon, Wyszynski, Michael, Huh, Kyung-Hye, Valtschanoff, Juli G, Lee, Jae-Ran, Ko, Jaewon, Streuli, Michel, Weinberg, Richard J, Sheng, Morgan, Kim, Eunjoon

“…Liprin-alpha/SYD-2 is a multimodular scaffolding protein important for presynaptic differentiation and postsynaptic targeting of…”
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Neurotransmitter Release Regulated by a MALS-Liprin-α Presynaptic Complex by Olsen, Olav, Moore, Kimberly A., Fukata, Masaki, Kazuta, Toshinari, Trinidad, Jonathan C., Kauer, Fred W., Streuli, Michel, Misawa, Hidemi, Burlingame, Alma L., Nicoll, Roger A., Bredt, David S.

“…Synapses are highly specialized intercellular junctions organized by adhesive and scaffolding molecules that align presynaptic vesicular release with…”
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Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors by Gao, Y, Xing, J, Streuli, M, Leto, T L, Zheng, Y

“…Signaling specificity of Rho GTPase pathways is achieved in part by selective interaction between members of the Dbl family guanine nucleotide exchange factors…”
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The Multidomain Protein Trio Binds the LAR Transmembrane Tyrosine Phosphatase, Contains a Protein Kinase Domain, and has Separate Rac-Specific and Rho-Specific Guanine Nucleotide Exchange Factor Domains by Debant, Anne, Serra-Pagès, Carles, Seipel, Katja, O'Brien, Stephen, Tang, May, Park, Sang-Ho, Streuli, Michel

“…rho-like GTP binding proteins play an essential role in regulating cell growth and actin polymerization. These molecular switches are positively regulated by…”
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Liprin Phosphorylation Regulates Binding to LAR:  Evidence for Liprin Autophosphorylation by Serra-Pagès, Carles, Streuli, Michel, Medley, Quintus G

“…The LAR transmembrane tyrosine phosphatase associates with liprin-α proteins and colocalizes with liprin-α1 at focal adhesions. LAR has been implicated in axon…”
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Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization by Seipel, K, O'Brien, S P, Iannotti, E, Medley, Q G, Streuli, M

“…Reorganization of the actin cytoskeleton is essential to numerous cellular processes including cell locomotion and cytokinesis. This actin remodeling is…”
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The LAR transmembrane protein tyrosine phosphatase and a coiled‐coil LAR‐interacting protein co‐localize at focal adhesions by Serra‐Pagès, C., Kedersha, N.L., Fazikas, L., Medley, Q., Debant, A., Streuli, M.

“…Focal adhesions are sites of cell‐extracellular matrix interactions that function in anchoring stress fibers to the plasma membrane and in adhesion‐mediated…”
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