Search Results - "Streuli, Charles H"

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium by Akhtar, Nasreen, Streuli, Charles H.

“…The extracellular matrix has a crucial role in determining the spatial orientation of epithelial polarity and the formation of lumens in glandular tissues;…”
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Integrins and cell-fate determination by Streuli, Charles H

“…All cellular processes are determined by adhesive interactions between cells and their local microenvironment. Integrins, which constitute one class of…”
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Integrins as architects of cell behavior by Streuli, Charles H

“…Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are…”
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Signal co-operation between integrins and other receptor systems by Streuli, Charles H, Akhtar, Nasreen

“…The multicellular nature of metazoans means that all cellular processes need to be tuned by adhesive interactions between cells and their local…”
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Integrins and epithelial cell polarity by Lee, Jessica L, Streuli, Charles H

“…Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial…”
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Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming by Schellenberg, Barbara, Wang, Pengbo, Keeble, James A., Rodriguez-Enriquez, Ricardo, Walker, Scott, Owens, Thomas W., Foster, Fiona, Tanianis-Hughes, Jolanta, Brennan, Keith, Streuli, Charles H., Gilmore, Andrew P.

“…The proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of nonapoptotic cells and is commonly thought to translocate to mitochondria following…”
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Rac1 Controls Both the Secretory Function of the Mammary Gland and Its Remodeling for Successive Gestations by Akhtar, Nasreen, Li, Weiping, Mironov, Aleksander, Streuli, Charles H.

“…An important feature of the mammary gland is its ability to undergo repeated morphological changes during each reproductive cycle with profound tissue…”
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Cellular mechano-environment regulates the mammary circadian clock by Yang, Nan, Williams, Jack, Pekovic-Vaughan, Vanja, Wang, Pengbo, Olabi, Safiah, McConnell, James, Gossan, Nicole, Hughes, Alun, Cheung, Julia, Streuli, Charles H., Meng, Qing-Jun

“…Circadian clocks drive ∼24 h rhythms in tissue physiology. They rely on transcriptional/translational feedback loops driven by interacting networks of clock…”
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The C terminus of talin links integrins to cell cycle progression by Wang, Pengbo, Ballestrem, Christoph, Streuli, Charles H

“…Integrins are cell adhesion receptors that sense the extracellular matrix (ECM) environment. One of their functions is to regulate cell fate decisions,…”
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Integrin-Rac signalling for mammary epithelial stem cell self-renewal by Olabi, Safiah, Ucar, Ahmet, Brennan, Keith, Streuli, Charles H

“…Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a…”
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FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis by Zhang, Xiaohong, Martinez, Denisse, Koledova, Zuzana, Qiao, Guijuan, Streuli, Charles H, Lu, Pengfei

“…FGF signaling is essential for mammary gland development, yet the mechanisms by which different members of the FGF family control stem cell function and…”
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Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes by Duran-Jimenez, Beatriz, Dobler, Darin, Moffatt, Sarah, Rabbani, Naila, Streuli, Charles H, Thornalley, Paul J, Tomlinson, David R, Gardiner, Natalie J

“…Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes Beatriz Duran-Jimenez 1 ,…”
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Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells by Bridgewater, Rebecca E., Streuli, Charles H., Caswell, Patrick T.

“…The hormone prolactin promotes lactational differentiation of mammary epithelial cells (MECs) via its cognate receptor and the downstream JAK2-STAT5a…”
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A Role for β3-Integrins in Linking Breast Development and Cancer by Ucar, Ahmet, Streuli, Charles H.

“…Pregnancy induces a rapid and controlled expansion of mammary stem cells. In this issue of Developmental Cell, Desgrosellier et al. (2014) show that…”
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Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours by Broadberry, Eleanor, McConnell, James, Williams, Jack, Yang, Nan, Zindy, Egor, Leek, Angela, Waddington, Rachel, Joseph, Leena, Howe, Miles, Meng, Qing-Jun, Streuli, Charles H

“…Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA…”
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The Immunology of Breast Development by Travis, Mark A., Streuli, Charles H.

“…The immune system is not normally viewed as a regulator of breast development. However, in this issue of Developmental Cell, Plaks et al. (2015) reveal that…”
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The extracellular matrix as an adhesion checkpoint for mammary epithelial function by Katz, Elad, Streuli, Charles H.

“…The development of the mammary gland is spatially regulated by the interaction of the mammary epithelium with the extracellular matrix (ECM). Cells receive…”
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FAK engages multiple pathways to maintain survival of fibroblasts and epithelia - differential roles for paxillin and p130Cas by Zouq, Nadia K, Keeble, James A, Lindsay, Jennefer, Valentijn, Anthony J, Zhang, Lu, Mills, Deborah, Turner, Christopher E, Streuli, Charles H, Gilmore, Andrew P

“…Different cell types interpret their distinct extracellular matrix (ECM) environments to bring about specific cell fate decisions, and can differentiate or…”
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Phosphorylation of the Proapoptotic BH3-Only Protein Bid Primes Mitochondria for Apoptosis during Mitotic Arrest by Wang, Pengbo, Lindsay, Jennefer, Owens, Thomas W., Mularczyk, Ewa J., Warwood, Stacey, Foster, Fiona, Streuli, Charles H., Brennan, Keith, Gilmore, Andrew P.

“…Mitosis is a moment of exquisite vulnerability for a metazoan cell. Failure to complete mitosis accurately can lead to aneuploidy and cancer initiation…”
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Signalling pathways linking integrins with cell cycle progression by Moreno-Layseca, Paulina, Streuli, Charles H.

“…Integrins are adhesion receptors that allow cells to sense and respond to microenvironmental signals encoded by the extracellular matrix. They are crucial for…”
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