Frailty in Non-geriatric Patients With Head and Neck cancer

Patients with head and neck cancer (HNC) are characterized by a poor lifestyle and comorbidity. The Geriatric 8 (G8) is an established screening tool to identify frail older patients with cancer. However, studies evaluating frailty in younger HNC patients are lacking. The aim of this study is to eva...

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Bibliographic Details
Published in:	Otolaryngology-head and neck surgery Vol. 169; no. 5; pp. 1215 - 1224
Main Authors:	Bakas, Ajay T, Polinder-Bos, Harmke A, Streng, Fleur, Mattace-Raso, Francesco U S, Ziere, Gijsbertus, de Jong, Rob J Baatenburg, Sewnaik, Aniel
Format:	Journal Article
Language:	English
Published:	England 01-11-2023
Subjects:	Comprehensive Geriatric Assessment G8 frailty head and neck cancer
Online Access:	Get full text
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Summary:	Patients with head and neck cancer (HNC) are characterized by a poor lifestyle and comorbidity. The Geriatric 8 (G8) is an established screening tool to identify frail older patients with cancer. However, studies evaluating frailty in younger HNC patients are lacking. The aim of this study is to evaluate if the G8 can identify frailty and if it is related to mortality in younger HNC patients. Case-control study design. Tertiary cancer center. We studied patients <70 years with HNC. Patients with G8 ≤ 14 were considered frail. Patients were matched to nonfrail (G8 > 14) control patients. Patients were matched according to sex, age, smoking, tumor location, and period of first consultation. Baseline health characteristics were compared between frail patients and nonfrail controls. Second, the treatment plan and adverse outcomes were compared. Forty-five patients with G8 ≤ 14 were included and matched to 90 nonfrail controls. The median follow-up time was 357 days. Frail patients had a significantly lower body mass index and level of education, a worse World Health Organization performance status, and reported lower experienced overall health. 28.9% of the frail patients died after 1 year versus 10% of the nonfrail control patients (hazard ratio: 3.87 [95% confidence interval: 1.32-11.36], p = 0.014). The G8 is a valid screening tool to identify frail patients in younger HNC patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0194-5998 1097-6817
DOI:	10.1002/ohn.388