Search Results - "Stremovskiy, O. A."

A new anticancer toxin based on HER2/neu-specific DARPin and photoactive flavoprotein miniSOG by Proshkina, G.M., Shilova, O.N., Ryabova, A.V., Stremovskiy, O.A., Deyev, S.M.

“…Cytotoxic effects of a new targeted phototoxin DARPin-miniSOG and mechanism of its action were investigated in vitro. It was determined that DARPin-miniSOG…”
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Fusion of barnase to antiferritin antibody F11 VH domain results in a partially folded functionally active protein by Shubenok, D. V, Tsybovsky, Y. I, Stremovskiy, O. A, Deyev, S. M, Martsev, S. P

“…A chimeric protein, VH-barnase, was obtained by fusing the VH domain of anti-human ferritin monoclonal antibody F11 to barnase, a bacterial RNase from Bacillus…”
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Novel recombinant anti-HER2/neu immunotoxin: Design and antitumor efficiency by Sokolova, E. A., Zdobnova, T. A., Stremovskiy, O. A., Balalaeva, I. V., Deyev, S. M.

“…The novel HER2/neu-specific recombinant immunotoxin 4D5scFv-PE40 consisting of 4D5scFv antibody (targeting module) and Pseudomonas exotoxin A fragment…”
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Highly specific hybrid protein DARPin-mCherry for fluorescent visualization of cells overexpressing tumor marker HER2/neu by Mironova, K. E., Chernykh, O. N., Ryabova, A. V., Stremovskiy, O. A., Proshkina, G. M., Deyev, S. M.

“…Here we propose a simple and reliable approach for detection of the tumor marker HER2/neu using the targeting fluorescent hybrid protein DARPin-mCherry. As a…”
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Bifunctional Toxin DARP-LoPE Based on the Her2-Specific Innovative Module of a Non-Immunoglobulin Scaffold as a Promising Agent for Theranostics by Proshkina, G. M., Kiseleva, D. V., Shilova, O. N., Ryabova, A. V., Shramova, E. I., Stremovskiy, O. A., Deyev, S. M.

“…We have generated and characterized HER2-specific targeted toxin based on the low-immunogenic variant of Pseudomonas exotoxin A (LoPE), in which most of the…”
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Synthesis of Magnetic Nanoparticles Stabilized by Magnetite-Binding Protein for Targeted Delivery to Cancer Cells by Kotelnikova, P. A., Shipunova, V. O., Aghayeva, U. F., Stremovskiy, O. A., Nikitin, M. P., Novikov, I. A., Schulga, A. A., Deyev, S. M., Petrov, R. V.

“…A new method for obtaining biomodified magnetite nanoparticles for targeted delivery to cells was developed. The method is based on the use of the C-terminal…”
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Fusion of the antiferritin antibody VL domain to barnase results in enhanced solubility and altered pH stability by Martsev, Sergey P., Tsybovsky, Yaroslav I., Stremovskiy, Oleg A., Odintsov, Sergey G., Balandin, Taras G., Arosio, Paolo, Kravchuk, Zinaida I., Deyev, Sergey M.

“…Chimeric immunotoxins that combine antigen recognition domains of antibodies and cytotoxic RNases have attracted much attention in recent years as potential…”
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A Novel Approach to Anticancer Therapy: Molecular Modules Based on the Barnase:Barstar Pair for Targeted Delivery of HSP70 to Tumor Cells by Sapozhnikov, A M, Klinkova, A V, Shustova, O A, Grechikhina, M V, Kilyachus, M S, Stremovskiy, O A, Kovalenko, E I, Deyev, S M

“…One important distinction between many tumor cell types and normal cells consists in the translocation of a number of intracellular proteins, in particular the…”
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Bifunctional Toxin DARP-LoPE Based on the HER2-Specific Innovative Module of a Non-Immunoglobulin Scaffold as a Promising Agent for Theranostics by Proshkina, G M, Kiseleva, D V, Shilova, O N, Ryabova, A V, Shramova, E I, Stremovskiy, O A, Deyev, S M

“…We have generated and characterized HER2-specific targeted toxin based on the low-immunogenic variant of Pseudomonas exotoxin A (LoPE), in which most of the…”
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Recombinant Immunotoxin 4D5scFv-PE40 for Targeted Therapy of HER2-Positive Tumors by Sokolova, E A, Stremovskiy, O A, Zdobnova, T A, Balalaeva, I V, Deyev, S M

“…Recombinant immunotoxins are extremely promising agents for the targeted therapy of tumors with a certain molecular profile. In this work, we studied the…”
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Specific visualization of tumor cells using upconversion nanophosphors by Grebenik, E A, Generalova, A N, Nechaev, A V, Khaydukov, E V, Mironova, K E, Stremovskiy, O A, Lebedenko, E N, Zvyagin, A V, Deyev, S M

“…The development of targeted constructs on the basis of photoluminescent nanoparticles with a high photo- and chemical stability and absorption/emission spectra…”
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Folding and stability of chimeric immunofusion VL-barstar by Tsybovsky, Y I, Shubenok, D V, Stremovskiy, O A, Deyev, S M, Martsev, S P

“…A chimeric protein VL-barstar that comprises the VL domain of anti-human ferritin monoclonal antibody F11 and barstar, the naturally occurring inhibitor of…”
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Fluorescent nanodiamond bioconjugates on the base of barnase:barstar module by Ivukina, E. A., Sreenivasan, V. K. A., Stremovskiy, O. A., Veryugin, B. V., Lukash, S. V., Zvyagin, A. V., Deyev, S. M., Petrov, R. V.

“…Research aimed at investigating the methods and opportunities for application of nanometer size parti cles is currently an actively developed field in…”
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Anti-EGFR-miniantibody-barnase immunoconjugate is highly toxic for human tumor cells by Edelweiss, E. F., Balandin, T. G., Stremovskiy, O. A., Deyev, S. M., Petrov, R. V.

“…Development of effective antitumor drugs is a topical problem of modern biology and medicine. A promising approach is creating antibodies that specifically…”
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Imaging of human ovarian cancer SKOV-3 cells by quantum dot bioconjugates by Zdobnova, T. A., Dorofeev, S. G., Tananaev, P. N., Zlomanov, V. P., Stremovskiy, O. A., Lebedenko, E. N., Balalaeva, I. V., Deyev, S. M., Petrov, R. V.

“…Development of molecular approaches to treatment of oncological diseases determines the necessity of development ultrasensitive and highly precise methods for…”
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Expression of anti-tumor recombinant IgG- and IgE-like genes in eukaryotic cells by Polanovsky, O. L., Lukash, S. V., Stremovskiy, O. A., Karpenko, D. V., Deyev, S. M.

“…The tandem of humanized variable VL and VH genes (ScFv fragment 4D5) possessing a high affinity to the HER-2/neu oncogene (the epidermal growth factor receptor…”
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Production of recombinant antitumor antibodies by HEK-293 cells by Deyev, S M, Stremovskiy, O A, Lukash, S V, Karpenko, D V, Polyanovsky, O L, Petrov, R V

“…(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT]…”
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A Novel Approach to Anticancer Therapy: Molecular Modules Based on the Barnase:Barstar Pair for Targeted Delivery of HSP70 to Tumor Cells by Sapozhnikov, A. M., Klinkova, A. V., Shustova, O. A., Grechikhina, M. V., Kilyachus, M. S., Stremovskiy, O. A., Kovalenko, E. I., Deyev, S. M.

“…One important distinction between many tumor cell types and normal cells consists in the translocation of a number of intracellular proteins, in particular the…”
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Specific Visualization of Tumor Cells Using Upconversion Nanophosphors by Grebenik, E. A., Generalova, A. N., Nechaev, A. V., Khaydukov, E.V., Mironova, K. E., Stremovskiy, O. A., Lebedenko, E.N., Zvyagin, A. V., Deyev, S. M.

“…The development of targeted constructs on the basis of photoluminescent nanoparticles with a high photo- and chemical stability and absorption/emission spectra…”
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Expression of single-chain antibody-barstar fusion in plants by Semenyuk, Ekaterina G., Stremovskiy, Oleg A., Edelweiss, Evelina F., Shirshikova, Olga V., Balandin, Taras G., Buryanov, Yaroslav I., Deyev, Sergey M.

“…We successfully cloned and expressed a single-chain antibody (425scFv), that is directed to human epidermal growth factor receptor HER1 (EGFR) in transgenic…”
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