Search Results - "Strell, C."

A novel pancreatic tumour and stellate cell 3D co-culture spheroid model by Norberg, K J, Liu, X, Fernández Moro, C, Strell, C, Nania, S, Blümel, M, Balboni, A, Bozóky, B, Heuchel, R L, Löhr, J M

“…Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this…”
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Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features by Pellinen, Teijo, Paavolainen, Lassi, Martín-Bernabé, Alfonso, Papatella Araujo, Renata, Strell, Carina, Mezheyeuski, Artur, Backman, Max, La Fleur, Linnea, Brück, Oscar, Sjölund, Jonas, Holmberg, Erik, Välimäki, Katja, Brunnström, Hans, Botling, Johan, Moreno-Ruiz, Pablo, Kallioniemi, Olli, Micke, Patrick, Östman, Arne

“…Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer anti- and…”
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A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation by Harryvan, T.J., Hawinkels, L.J.A.C., Inderson, A., van Hooft, J.E., Micke, P., Johansen, J.S., van Wezel, T., Crobach, S., Baart, V.M., Quist, B.S., Roet, J.E.G., Kop, M.E., Östman, A., ten Dijke, P., Strell, C., Hornsveld, M.

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Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction by Strell, C, Lang, K, Niggemann, B, Zaenker, K. S, Entschladen, F

“…The extravasation of leukocytes and tumor cells is a multi-step process with the involvement of various adhesion molecules depending on the three steps…”
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High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer by Paulsson, Janna, Rydén, Lisa, Strell, Carina, Frings, Oliver, Tobin, Nicholas P, Fornander, Tommy, Bergh, Jonas, Landberg, Göran, Stål, Olle, Östman, Arne

“…Cancer‐associated fibroblasts (CAFs) regulate tumour growth, metastasis and response to treatment. Recent studies indicate the existence of functionally…”
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Fibroblast-dependent regulation of the stem cell properties of cancer cells by Weiland, A, Roswall, P, Hatzihristidis, T C, Pietras, K, Ostman, A, Strell, C

“…There is emerging evidence that cancer stem cells (CSCs), like normal tissue stem cells, are regulated by a niche formed of mesenchymal cells. In this review…”
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Functional and clinical roles of stromal PDGF receptors in tumor biology by Strell, Carina, Rodríguez-Tomàs, Elisabet, Östman, Arne

“…PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine…”
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Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ by Strell, Carina, Paulsson, Janna, Jin, Shao-Bo, Tobin, Nicholas P, Mezheyeuski, Artur, Roswall, Pernilla, Mutgan, Ceren, Mitsios, Nicholas, Johansson, Hemming, Wickberg, Sarah Marie, Svedlund, Jessica, Nilsson, Mats, Hall, Per, Mulder, Jan, Radisky, Derek C, Pietras, Kristian, Bergh, Jonas, Lendahl, Urban, Wärnberg, Fredrik, Östman, Arne

“…A better definition of biomarkers and biological processes related to local recurrence and disease progression is highly warranted for ductal breast carcinoma…”
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Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome by Mezheyeuski, Artur, Segersten, Ulrika, Leiss, Lina Wik, Malmström, Per-Uno, Hatina, Jiri, Östman, Arne, Strell, Carina

“…Little attention was given to the interaction between tumor and stromal cells in urothelial bladder carcinoma (UBC). While recent studies point towards the…”
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Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study by Strell, Carina, Smith, Daniel Robert, Valachis, Antonis, Woldeyesus, Hellén, Wadsten, Charlotta, Micke, Patrick, Fredriksson, Irma, Schiza, Aglaia

“…Background Retrospective observational studies suggest a potential role of beta-blockers as a protective strategy against progression and metastasis in…”
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Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation by Moreno-Ruiz, Pablo, Corvigno, Sara, te Grootenhuis, Nienke C., La Fleur, Linnéa, Backman, Max, Strell, Carina, Mezheyeuski, Artur, Hoelzlwimmer, Gabriele, Klein, Christian, Botling, Johan, Micke, Patrick, Östman, Arne

“…•High FAP stroma intensity is a poor prognosis marker in non-small cell lung cancer.•P53 mutation is positively associated with fibroblast stroma…”
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Astrocytes enhance glioblastoma growth by Mega, Alessandro, Hartmark Nilsen, Mette, Leiss, Lina Wik, Tobin, Nicholas P., Miletic, Hrvoje, Sleire, Linda, Strell, Carina, Nelander, Sven, Krona, Cecilia, Hägerstrand, Daniel, Enger, Per Ø., Nistér, Monica, Östman, Arne

“…Glioblastoma (GBM) is a deadly disease with a need for deeper understanding and new therapeutic approaches. The microenvironment of glioblastoma has previously…”
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Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer by Backman, Max, Strell, Carina, Lindberg, Amanda, Mattsson, Johanna S.M., Elfving, Hedvig, Brunnström, Hans, O'Reilly, Aine, Bosic, Martina, Gulyas, Miklos, Isaksson, Johan, Botling, Johan, Kärre, Klas, Jirström, Karin, Lamberg, Kristina, Pontén, Fredrik, Leandersson, Karin, Mezheyeuski, Artur, Micke, Patrick

“…Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune…”
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Vessel size as a marker of survival in estrogen receptor positive breast cancer by Milosevic, Vladan, Edelmann, Reidunn J., Winge, Ingeborg, Strell, Carina, Mezheyeuski, Artur, Knutsvik, Gøril, Askeland, Cecilie, Wik, Elisabeth, Akslen, Lars A., Östman, Arne

“…Purpose Angiogenesis is crucial for tumor growth and is one of the hallmarks of cancer. In this study, we analyzed microvessel density, vessel median size, and…”
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High PDGFRb Expression Predicts Resistance to Radiotherapy in DCIS within the SweDCIS Randomized Trial by Strell, Carina, Folkvaljon, Dick, Holmberg, Erik, Schiza, Aglaia, Thurfjell, Viktoria, Karlsson, Per, Bergh, Jonas, Bremer, Troy, Akslen, Lars A, Wärnberg, Fredrik, Östman, Arne

“…This study analyzes the potential of stromal platelet-derived growth factor receptor-beta (PDGFRb) expression as biomarker for radiotherapy (RT) benefit on…”
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Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer by Backman, Max, La Fleur, Linnéa, Kurppa, Pinja, Djureinovic, Dijana, Elfving, Hedvig, Brunnström, Hans, Mattsson, Johanna Sofia Margareta, Lindberg, Amanda, Pontén, Victor, Eltahir, Mohamed, Mangsbo, Sara, Gulyas, Miklos, Isaksson, Johan, Jirström, Karin, Kärre, Klas, Leandersson, Karin, Mezheyeuski, Artur, Pontén, Fredrik, Strell, Carina, Lindskog, Cecilia, Botling, Johan, Micke, Patrick

“…Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of…”
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Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer by Kilvaer, Thomas Karsten, Rakaee, Mehrdad, Hellevik, Turid, Østman, Arne, Strell, Carina, Bremnes, Roy M, Busund, Lill-Tove, Dønnem, Tom, Martinez-Zubiaurre, Inigo

“…Selective targeting of cancer-associated fibroblasts (CAFs) has been proposed to synergize with immune-checkpoint inhibitors. While the roles of CAFs in cancer…”
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SIRT1 inhibition in pancreatic cancer models: Contrasting effects in vitro and in vivo by Oon, Chern Ein, Strell, Carina, Yeong, Keng Yoon, Östman, Arne, Prakash, Jai

“…Gemcitabine remains the standard treatment for pancreatic cancer, although most patients acquire resistance to the therapy. Up-regulated in pancreatic cancer,…”
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Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments by EHNMAN, Monika, MISSIAGLIA, Edoardo, ERIKSSON, Ulf, FOLESTAD, Erika, SELFE, Joanna, STRELL, Carina, THWAY, Khin, BRODIN, Bertha, PIETRAS, Kristian, SHIPLEY, Janet, ÖSTMAN, Arne

“…Platelet-derived growth factor receptors (PDGFR) α and β have been suggested as potential targets for treatment of rhabdomyosarcoma, the most common soft…”
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Prognostic and predictive impact of stroma cells defined by PDGFRb expression in early breast cancer: results from the randomized SweBCG91RT trial by Strell, Carina, Stenmark Tullberg, Axel, Jetne Edelmann, Reidunn, Akslen, Lars Andreas, Malmström, Per, Fernö, Mårten, Holmberg, Erik, Östman, Arne, Karlsson, Per

“…Purpose Predictive biomarkers are needed to aid the individualization of radiotherapy (RT) in breast cancer. Cancer-associated fibroblasts have been implicated…”
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