Search Results - "Strelkova, Daria"

Branched‐Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH by Hajj, Khalid A., Ball, Rebecca L., Deluty, Sarah B., Singh, Shridhar R., Strelkova, Daria, Knapp, Christopher M., Whitehead, Kathryn A.

“…The potential of mRNA therapeutics will be realized only once safe and effective delivery systems are established. Unfortunately, delivery vehicle development…”
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The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism by Strelkova Petersen, Daria M., Chaudhary, Namit, Arral, Mariah L., Weiss, Ryan M., Whitehead, Kathryn A.

“…[Display omitted] mRNA is a versatile drug molecule with therapeutic applications ranging from protein replacement therapies to in vivo gene engineering. mRNA…”
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Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes by Chaudhary, Namit, Newby, Alexandra N, Arral, Mariah L, Yerneni, Saigopalakrishna S, LoPresti, Samuel T, Doerfler, Rose, Petersen, Daria M Strelkova, Montoya, Catalina, Kim, Julie S, Fox, Bethany, Coon, Tiffany, Malaney, Angela, Sadovsky, Yoel, Whitehead, Kathryn A

“…Treating pregnancy-related disorders is exceptionally challenging because the threat of maternal and/or fetal toxicity discourages the use of existing…”
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Branched‐Tail Lipid Nanoparticles for Intravenous mRNA Delivery to Lung Immune, Endothelial, and Alveolar Cells in Mice by Petersen, Daria M. Strelkova, Weiss, Ryan M., Hajj, Khalid A., Yerneni, Saigopalakrishna S., Chaudhary, Namit, Newby, Alexandra N., Arral, Mariah L., Whitehead, Kathryn A.

“…Lipid nanoparticles (LNPs) are proven safe and effective delivery systems on a global scale. However, their efficacy has been limited primarily to liver and…”
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The Antibiotic Knowledge, Attitudes, and Behaviors of Patients Purchasing Antibiotics without Prescription: Results of National Survey by Rachina, Svetlana, Zakharenkova, Polina, Kozlov, Roman, Palagin, Ivan, Mamchich, Daria, Strelkova, Daria

“…Background. The inappropriate and overuse of antimicrobials is a problem worldwide. To target future interventions, a thorough understanding of current…”
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Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d by Chaudhary, Namit, Kasiewicz, Lisa N, Newby, Alexandra N, Arral, Mariah L, Yerneni, Saigopalakrishna S, Melamed, Jilian R, LoPresti, Samuel T, Fein, Katherine C, Strelkova Petersen, Daria M, Kumar, Sushant, Purwar, Rahul, Whitehead, Kathryn A

“…Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicle for RNA therapeutics, partly because of established lipid structure-activity…”
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A Clinical Case of Nosocomial Pneumonia as a Complication of COVID-19: How to Balance Benefits and Risks of Immunosuppressive Therapy? by Rachina, Svetlana, Kiyakbaev, Gairat, Antonova, Elena, Mescheryakov, Alexey, Kupryushina, Olga, Hewathanthirige, Girindu, Palagin, Ivan, Kozhevnikova, Elena, Sukhorukova, Marina, Strelkova, Daria

“…We report a Russian case of a 61-year-old male patient with confirmed COVID-19 infection who developed nosocomial pneumonia complicated by lung abscess…”
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Rapidly Progressive Portal Cavernoma Cholangiopathy in a Patient With Infeasible Decompressive Shunt Surgery by Nadinskaia, Maria Yu, Ivashkin, Vladimir T., Nekrasova, Tatiana Р., Novruzbekov, Murad S., Zimina, Larisa N., Kodzoeva, Khava B., Strelkova, Daria A.

“…We present a 27-year-old man with a 2-year history of extrahepatic portal vein obstruction and selective immunoglobulin A deficiency, referred for acute…”
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Lungs Ultrasound in SARS-Cov-2 Diagnostics: a Prospective Comparative Study of 30 Patients with COVID-19 Pneumonia by Svetlana A. Rachina, Daria A. Strelkova, Flora E. Cabello Montoya, Olga T. Zorya, Ayten F. Safarova, Olga V. Aryutina, Stanislav K. Gruzdev, Vladimir V. Mladov

“…INTRODUCTION. Lung ultrasound has been widely used to diagnose bacterial pneumonia, pulmonary congestion in heart failure, pneumo- and hydrothorax, and other…”
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Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery by Melamed, Jilian R., Hajj, Khalid A., Chaudhary, Namit, Strelkova, Daria, Arral, Mariah L., Pardi, Norbert, Alameh, Mohamad-Gabriel, Miller, Jason B., Farbiak, Lukas, Siegwart, Daniel J., Weissman, Drew, Whitehead, Kathryn A.

“…Therapeutic mRNA has the potential to revolutionize the treatment of myriad diseases and, in 2020, facilitated the most rapid vaccine development in history…”
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Factor XII Silencing Using siRNA Prevents Thrombus Formation in a Rat Model of Extracorporeal Life Support by Umei, Nao, Shin, Suji, Lai, Angela, Miller, Jennifer, Roberts, Kalliope, Strelkova, Daria, Chaudhary, Namit, Ichiba, Shingo, Sakamoto, Atsuhiro, Whitehead, Kathryn, Cook, Keith

“…Heparin anticoagulation increases the bleeding risk during extracorporeal life support (ECLS). This study determined whether factor XII (FXII) silencing using…”
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The antibiotic knowledge, attitudes and behaviours of patients purchasing antibiotics with prescription in Russia: a qualitative, comparative analysis by Rachina, Svetlana, Zakharenkova, Polina, Kozlov, Roman, Palagin, Ivan, Shishkina, Ksenia, Strelkova, Daria, Mamchich, Daria

“…Abstract Objectives The study aimed to investigate behaviour, knowledge and practices towards antibiotic (AB) use among patients who purchased ABs with a…”
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Co-Infection in COVID-19 Pneumonia: Discussion Continues by Strelkova, Daria, Rachina, Svetlana, Klimenko, Alexey, Yatsyshina, Svetlana, Cheboksarov, Dmitry, Cherkasova, Tatiana, Ramazanov, Natig, Ananicheva, Nataliia

“…Sixty-six patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 and pneumonia on chest computer tomography were prospectively…”
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Factor XII Silencing Using siRNA Prevents Thrombus Formation in a Rat Model of Extracorporeal Life Support by Umei, Nao, Shin, Suji, Lai, Angela, Miller, Jennifer, Roberts, Kalliope, Strelkova, Daria, Chaudhary, Namit, Ichiba, Shingo, Sakamoto, Atsuhiro, Whitehead, Kathryn, Cook, Keith

“…Heparin anticoagulation increases the bleeding risk during extracorporeal life support (ECLS). This study determined whether factor XII (FXII) silencing using…”
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Microbiological monitoring of COVID-19 patients in the ICU: a prospective observational study by Strelkova, Daria А., Rachina, Svetlana A., Kuleshov, V.G., Burmistrova, E.N., Sychev, Igor N., Ananicheva, N.A., Vasileva, Yu.Yu, Churkina, E.A.

“…Objective. To study spectrum of pathogens and the time to colonization of respiratory samples in patients with severe and critical COVID-19 as well as to…”
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Differential diagnosis of community-acquired bacterial pneumonia and viral lung injury in hospitalized adults by Strelkova, Daria А., Kupryushina, O.A., Yasneva, A.S., Rachina, Svetlana A., Avdeev, S.N., Vlasenko, A.E., Fedina, L.V., Ivanova, O.V., Kaledina, I.V., Ananicheva, N.A.

“…Objective. Identification of clinical, laboratory, and instrumental factors more common in bacterial pneumonia compared to viral pneumonia, including COVID-19…”
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Invasive aspergillosis in patients with COVID-19 in intensive care units: results of a multicenter study by Shadrivova, Olga V., Rachina, Svetlana A., Strelkova, Daria А., Panchishina, K.A., Gusev, D.A., Vashukova, M.A., Meshchaninova, S.G., Zavrazhnov, A.A., Mitichkin, M.S., Mamonov, A.G., Khostelidi, Sofya N., Kozlova, O.P., Gusarov, Vitaly G., Zamyatin, M.N., Lovtsevich, N.V., Kuleshov, V.G., Shagdileeva, E.V., Oganesyan, E., Desyatik, E.A., Borzova, Yu.V., Ignatyeva, S.M., Vasilieva, N.V., Klimko, Nikolay N.

“…Objective. To study risk factors, clinical and radiological features and effectiveness of the treatment of invasive aspergillosis (IA) in adult patients with…”
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DDEL-01. ENGINEERING MRNA THERAPIES FOR BRAIN TUMORS by Yerneni, Saigopalakrishna, Azambuja, Juliana Hofstatter, Strelkova-Petersen, Daria, Gallagher, Brendan, Kim, Julie Shin, Chaudhary, Namit, Zhao, Yongxin, Lucas, Peter, McAllister-Lucas, Linda, Pardi, Norbert, Weissman, Drew, Whitehead, Kathryn

“…Abstract Safe delivery of mRNA to the brain will revolutionize the treatment of brain tumors. While lipid nanoparticles (LNPs) are clinically most advanced…”
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Messenger RNA Delivery with Lipid Nanoparticles to Non-Liver Targets by Petersen, Daria M. Strelkova

“…Lipid nanoparticle vehicles are effective tools for delivering messenger RNA therapeutics. They have been successfully used in Moderna and Pfizer vaccines…”
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Rapidly Progressive Portal Cavernoma Cholangiopathy in a Patient With Infeasible Decompressive Shunt Surgery by Nadinskaia, Maria Yu, Ivashkin, Vladimir T, Nekrasova, Tatiana Р, Novruzbekov, Murad S, Zimina, Larisa N, Kodzoeva, Khava B, Strelkova, Daria A

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