Search Results - "Streiff, John H."

Prediction of Volatile Anesthetic Binding Sites in Proteins by Streiff, John H., Allen, Thomas W., Atanasova, Elena, Juranic, Nenad, Macura, Slobodan, Penheiter, Alan R., Jones, Keith A.

“…Computational methods designed to predict and visualize ligand protein binding interactions were used to characterize volatile anesthetic (VA) binding sites…”
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Saturation transfer difference nuclear magnetic resonance spectroscopy as a method for screening proteins for anesthetic binding by Streiff, John H, Juranic, Nenad O, Macura, Slobodan I, Warner, David O, Jones, Keith A, Perkins, William J

“…The effects of anesthetics on cellular function may result from direct interactions between anesthetic molecules and proteins. These interactions have a low…”
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Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase by Juranić Nenad O., Jones Keith A., Penheiter Alan R., Hock Thomas J., Streiff John H.

“…The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the…”
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Volatile Anesthetic Binding to Proteins Is Influenced by Solvent and Aliphatic Residues by Streiff, John H, Jones, Keith A

“…The main objective of this work was to characterize VA binding sites in multiple anesthetic target proteins. A computational algorithm was used to quantify the…”
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Solvent‐induced differentiation of protein backbone hydrogen bonds in calmodulin by Juranić, Nenad, Atanasova, Elena, Streiff, John H., Macura, Slobodan, Prendergast, Franklyn G.

“…In apo and holoCaM, almost half of the hydrogen bonds (H‐bonds) at the protein backbone expected from the corresponding NMR or X‐ray structures were not…”
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Effect of halothane on Gαi-3 and its coupling to the M2 muscarinic receptor by FANG JIN, SHUYAN WANG, SPENCER, Joshua D, PENHEITER, Sumedha G, STREIFF, John H, PENHEITER, Alan R, WARNER, David O, JONES, Keith A

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Effect of halothane on galphai-3 and its coupling to the M2 muscarinic receptor by Jin, Fang, Wang, Shuyan, Spencer, Joshua D, Penheiter, Sumedha G, Streiff, John H, Penheiter, Alan R, Warner, David O, Jones, Keith A

“…Halothane is an effective bronchodilator and inhibits airway smooth muscle contraction in part by inhibiting intracellular signaling pathways activated by the…”
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Effect of Halothane on Gαi-3and Its Coupling to the M2Muscarinic Receptor by Jin, Fang, Wang, Shuyan, Spencer, Joshua D., Penheiter, Sumedha G., Streiff, John H., Penheiter, Alan R., Warner, David O., Jones, Keith A.

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Halothane Does Not Inhibit the Basal GTPgS Binding Activity of Recombinant or Endogenous Gai Subunits: 2002[A-91 by Streiff, John H., Jones, Keith A., Warner, David O., Perkins, William J., Jones, Kristofer J.

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Investigation of the solvatochromic electronic transitions of [Ru(NH 3) 4bipyridine] 2 by Streiff, John H., Edwards, W.Daniel, McHale, Jeanne L.

“…The electronic transitions of [Ru(NH 3) 4bipyridine] 2+ were examined. The two longest wavelength absorption bands red-shift with increasing Gutmann donor…”
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