Search Results - "Streicher, Rüdiger"
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Potent Cholesteryl Ester Transfer Protein Inhibitors of Reduced Lipophilicity: 1,1′-Spiro-Substituted Hexahydrofuroquinoline Derivatives
Published in Journal of medicinal chemistry (13-11-2014)“…A series of 1,1′-spiro-substituted hexahydrofuroquinoline derivatives exhibiting potent cholesteryl ester transfer protein (CETP) inhibition at reduced…”
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2
Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats
Published in Endocrinology (Philadelphia) (01-10-2016)“…Plasma aldosterone is elevated in type 2 diabetes and obesity in experimental and clinical studies and can act to inhibit both glucose-stimulated insulin…”
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3
SREBP-1 Mediates Activation of the Low Density Lipoprotein Receptor Promoter by Insulin and Insulin-like Growth Factor-I
Published in The Journal of biological chemistry (22-03-1996)“…Transcription of the low density lipoprotein (LDL) receptor gene is regulated by intracellular cholesterol concentration, hormones, and growth factors. We…”
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4
Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes
Published in Biochemical journal (01-06-2008)“…In Type 2 diabetes, increased glycogenolysis contributes to the hyperglycaemic state, therefore the inhibition of GP (glycogen phosphorylase), a key…”
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5
Molecular Recognition of the Protein Phosphatase 1 Glycogen Targeting Subunit by Glycogen Phosphorylase
Published in The Journal of biological chemistry (04-04-2008)“…Disrupting the interaction between glycogen phosphorylase and the glycogen targeting subunit (GL) of protein phosphatase 1 is emerging as a novel target for…”
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6
BI-32169, a Bicyclic 19-Peptide with Strong Glucagon Receptor Antagonist Activity from Streptomyces sp
Published in Journal of natural products (Washington, D.C.) (01-09-2004)“…A new bicyclic 19-peptide, BI-32169 (1), has been isolated from the culture broth of Streptomyces sp. (DSM 14996). Its structure has been established by amino…”
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7
Interleukin-1-induced nuclear factor kappa B activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line
Published in Biochemical journal (15-11-1997)“…Oxygen radicals are commonly accepted mediators in the tumour necrosis factor-mediated nuclear factor kappa B (NF kappa B) signalling cascade, but evidence for…”
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8
Determinants of PHGPx expression in a cultured endothelial cell line
Published in Biomedical and environmental sciences (01-09-1997)“…Selenoprotein biosynthesis may not only be affected by the availability of selenium and the transcription rate of pertinent genes but also by the activity of…”
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Recombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinase
Published in The Journal of biological chemistry (03-03-1995)“…Insulin receptor substrate-1 (IRS-1) is a major endogenous substrate of the insulin receptor. To study the interaction of the insulin receptor with IRS-1 in…”
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10
Recombinant Human Insulin Receptor Substrate-1 Protein
Published in The Journal of biological chemistry (03-03-1995)“…Insulin receptor substrate-1 (IRS-1) is a major endogenous substrate of the insulin receptor. To study the interaction of the insulin receptor with IRS-1 in…”
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11
The organization of the human myelin basic protein gene. Comparison with the mouse gene
Published in Biological chemistry Hoppe-Seyler (01-05-1989)“…The organization of the gene of the human myelin basic protein has been established. The gene contains seven exons distributed over 32-34 kb. The nucleotide…”
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