Search Results - "Streicher, John M."

Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity by LaVigne, Justin E., Hecksel, Ryan, Keresztes, Attila, Streicher, John M.

“…Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids…”
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The role of opioid receptors in modulating Alzheimer's Disease by Tanguturi, Parthasaradhireddy, Streicher, John M

“…Alzheimer's disease (AD) is a complex neurological disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Long term…”
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Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids by Olson, Keith M, Duron, David I, Womer, Daniel, Fell, Ryan, Streicher, John M

“…Most clinically used opioids are thought to induce analgesia through activation of the mu opioid receptor (MOR). However, disparities have been observed…”
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TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth by Shah, Nirav, Kumar, Sanjay, Zaman, Naveed, Pan, Christopher C., Bloodworth, Jeffrey C., Lei, Wei, Streicher, John M., Hempel, Nadine, Mythreye, Karthikeyan, Lee, Nam Y.

“…Acetylation of microtubules (MT) confers mechanical stability necessary for numerous functions including cell cycle and intracellular transport. Although αTAT1…”
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Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors by Zhou, Lei, Lovell, Kimberly M., Frankowski, Kevin J., Slauson, Stephen R., Phillips, Angela M., Streicher, John M., Stahl, Edward, Schmid, Cullen L., Hodder, Peter, Madoux, Franck, Cameron, Michael D., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.

“…The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means to modulate pain perception, stress responses, and affective reward…”
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MAPK-Activated Protein Kinase-2 in Cardiac Hypertrophy and Cyclooxygenase-2 Regulation in Heart by Streicher, John M, Ren, Shuxun, Herschman, Harvey, Wang, Yibin

“…RATIONALE:Activation of p38 mitogen-activated protein kinase (MAPK) has a significant impact on cardiac gene expression, contractility, extracellular matrix…”
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Correction: Tanguturi et al. Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists. Molecules 2021, 26 , 6693 by Tanguturi, Parthasaradhireddy, Pathak, Vibha, Zhang, Sixue, Moukha-Chafiq, Omar, Augelli-Szafran, Corinne E, Streicher, John M

“…There was an error in the original publication [...]…”
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Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists by Tanguturi, Parthasaradhireddy, Pathak, Vibha, Zhang, Sixue, Moukha-Chafiq, Omar, Augelli-Szafran, Corinne E, Streicher, John M

“…The delta opioid receptor (DOR) is a crucial receptor system that regulates pain, mood, anxiety, and similar mental states. DOR agonists, such as SNC80, and…”
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Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment by Duron, David I., Tanguturi, Parthasaradhireddy, Campbell, Christopher S., Chou, Kerry, Bejarano, Paul, Gabriel, Katherin A., Bowden, Jessica L., Mishra, Sanket, Brackett, Christopher, Barlow, Deborah, Houseknecht, Karen L., Blagg, Brian S. J., Streicher, John M.

“…Opioids are the gold standard for the treatment of chronic pain but are limited by adverse side effects. In our earlier work, we showed that Heat shock protein…”
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Synthesis and In Vitro Characterization of Glycopeptide Drug Candidates Related to PACAP1–23 by Apostol, Christopher R., Tanguturi, Parthasaradhireddy, Szabò, Lajos Z., Varela, Daniel, Gilmartin, Thiago, Streicher, John M., Polt, Robin

“…The search for efficacious treatment of neurodegenerative and progressive neuroinflammatory diseases continues, as current therapies are unable to halt or…”
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Elucidation on the In Vivo Activity of the Bivalent Opioid Peptide MACE2 against Several Types of Chronic Pain by Stefanucci, Azzurra, Marinaccio, Lorenza, Pieretti, Stefano, Mancuso, Joseph A., Stine, Carrie, Streicher, John M., Mollica, Adriano

“…Biphalin is a bivalent μ/δ opioid receptor agonist showing a promising therapeutic profile with reduced side effects, but as a peptide is limited by poor…”
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Editorial: Novel Molecular Targets for the Treatment of Pain by Largent-Milnes, Tally M, Canals, Meritxell, Streicher, John M

“…The Traynor group reviewed the role of Regulator of G Protein Signaling (RGS) proteins in regulating MOR activation, including the use of novel inhibitors to…”
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Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels by Shan, Zhiming, Cai, Song, Yu, Jie, Zhang, Zhongjun, Vallecillo, Tissiana Gabriela menna, Serafini, Maria Jin, Thomas, Ann Mary, Pham, Nancy Yen Ngan, Bellampalli, Shreya Sai, Moutal, Aubin, Zhou, Yuan, Xu, Guo-Bo, Xu, Ya-Ming, Luo, Shizhen, Patek, Marcel, Streicher, John M, Gunatilaka, A. A. Leslie, Khanna, Rajesh

“…No universally efficacious therapy exists for chronic pain, a disease affecting one-fifth of the global population. An overreliance on the prescription of…”
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Inhibition of HSP90 Preserves Blood-Brain Barrier Integrity after Cortical Spreading Depression by Palomino, Seph M, Levine, Aidan A, Wahl, Jared, Liktor-Busa, Erika, Streicher, John M, Largent-Milnes, Tally M

“…Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders, including migraine. Blood-brain barrier (BBB) permeability…”
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The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain by Lei, Wei, Duron, David I, Stine, Carrie, Mishra, Sanket, Blagg, Brian S J, Streicher, John M

“…Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and…”
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Increases in local skin temperature correlate with spontaneous foot lifting and heat hyperalgesia in both incisional inflammatory models of pain by Banik, Ratan K., Sia, Twan, Ibrahim, Mohab M., Sivanesan, Eellan, Uhelski, Megan, Pena, Adrian, Streicher, John M., Simone, Donald A.

“…Abstract Background: This study investigated if a localized increase in skin temperature in rat models of incisional and inflammatory pain correlates with the…”
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Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome by Wahl, Jared R, Vivek, Anjali, Palomino, Seph M, Almuslim, Moyad, Cottier, Karissa E, Langlais, Paul R, Streicher, John M, Vanderah, Todd W, Liktor-Busa, Erika, Largent-Milnes, Tally M

“…Pathologies of the blood-brain barrier (BBB) have been linked to a multitude of central nervous system (CNS) disorders whose pathology is poorly understood…”
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Diverse Actions of Ovarian Steroids in the Serotonin Neural System by Bethea, Cynthia L., Lu, Nick Z., Gundlah, Chrisana, Streicher, John M.

“…All of the serotonin-producing neurons of the mammalian brain are located in 10 nuclei in the mid- and hindbrain regions. The cells of the rostal nuclei…”
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Strategies towards safer opioid analgesics—A review of old and upcoming targets by Varga, Balazs R., Streicher, John M., Majumdar, Susruta

“…Opioids continue to be of use for the treatment of pain. Most clinically used analgesics target the μ opioid receptor whose activation results in adverse…”
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Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain by Tarselli, Michael A., Raehal, Kirsten M., Brasher, Alex K., Streicher, John M., Groer, Chad E., Cameron, Michael D., Bohn, Laura M., Micalizio, Glenn C.

“…Management of chronic pain continues to represent an area of great unmet biomedical need. Although opioid analgesics are typically embraced as the mainstay of…”
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