Search Results - "Streich, Frederick"

Capturing a substrate in an activated RING E3/E2–SUMO complex by Streich Jr, Frederick C., Lima, Christopher D.

“…Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin-like modifier (SUMO) regulates processes…”
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Structural and Functional Insights to Ubiquitin-Like Protein Conjugation by Streich, Frederick C, Lima, Christopher D

“…Attachment of ubiquitin (Ub) and ubiquitin-like proteins (Ubls) to cellular proteins regulates numerous cellular processes including transcription, the cell…”
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Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape by Martin, Constance J, Datta, Abhishek, Littlefield, Christopher, Kalra, Ashish, Chapron, Christopher, Wawersik, Stefan, Dagbay, Kevin B, Brueckner, Christopher T, Nikiforov, Anastasia, Danehy, Jr, Francis T, Streich, Jr, Frederick C, Boston, Christopher, Simpson, Allison, Jackson, Justin W, Lin, Susan, Danek, Nicole, Faucette, Ryan R, Raman, Pichai, Capili, Allan D, Buckler, Alan, Carven, Gregory J, Schürpf, Thomas

“…Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to…”
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Strategies to Trap Enzyme-Substrate Complexes that Mimic Michaelis Intermediates During E3-Mediated Ubiquitin-Like Protein Ligation by Streich, Jr, Frederick C, Lima, Christopher D

“…Most cellular functions rely on pathways that catalyze posttranslational modification of cellular proteins by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins…”
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Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015 by Dagbay, Kevin B., Treece, Erin, Streich, Frederick C., Jackson, Justin W., Faucette, Ryan R., Nikiforov, Anastasia, Lin, Susan C., Boston, Chris J., Nicholls, Samantha B., Capili, Allan D., Carven, Gregory J.

“…Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates…”
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An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis by Jackson, Justin W, Frederick C Streich, Jr, Pal, Ajai, Coricor, George, Boston, Chris, Brueckner, Christopher T, Canonico, Kaleigh, Chapron, Christopher, Cote, Shaun, Dagbay, Kevin B, Danehy, Jr, Francis T, Kavosi, Mania, Kumar, Sandeep, Lin, Susan, Littlefield, Christopher, Looby, Kailyn, Manohar, Rohan, Martin, Constance J, Wood, Marcie, Zawadzka, Agatha, Wawersik, Stefan, Nicholls, Samantha B, Datta, Abhishek, Buckler, Alan, Schürpf, Thomas, Carven, Gregory J, Qatanani, Mohammed, Fogel, Adam I

“…Inhibitors of the transforming growth factor-β (TGF-β) pathway are potentially promising antifibrotic therapies, but nonselective simultaneous inhibition of…”
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Tripartite Motif Ligases Catalyze Polyubiquitin Chain Formation through a Cooperative Allosteric Mechanism by Streich, Frederick C., Ronchi, Virginia P., Connick, J.Patrick, Haas, Arthur L.

“…Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification, often resulting in targeted degradation of conjugated proteins…”
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Convergent Evolution in the Assembly of Polyubiquitin Degradation Signals by the Shigella flexneri IpaH9.8 Ligase by Edwards, Daniel J., Streich, Frederick C., Ronchi, Virginia P., Todaro, Dustin R., Haas, Arthur L.

“…The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohort of effector proteins via a type III secretion system. The IpaH…”
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E1-E2 Interactions in Ubiquitin and Nedd8 Ligation Pathways by Tokgöz, Zeynep, Siepmann, Thomas J., Streich, Frederick, Kumar, Brajesh, Klein, Jennifer M., Haas, Arthur L.

“…Initial rates of E1-catalyzed E2 transthiolation have been used as a reporter function to probe the mechanism of 125I-ubiquitin transfer between activation and…”
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Activation of ubiquitin and ubiquitin-like proteins by Streich, Jr, Frederick C, Haas, Arthur L

“…Attachment of ubiquitin and ubiquitin-like proteins to cellular targets represents a fundamental regulatory strategy within eukaryotes and exhibits remarkably…”
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Selective Inhibition of Repulsive Guidance Molecule C/Hemojuvelin (RGMc/HJV) with SRK-256 to Mobilize Iron in Functional Iron Deficiency by Cortes, Leslie K., Nicholls, Samantha B., Streich, Frederick C., Boston, Chris, Pal, Ajai, Regmi, Bimal, Cote, Shaun M., Canonico, Kaleigh, Qatanani, Mo

“…Functional iron deficiency is a serious condition marked by serum iron restriction in the presence of adequate iron stores that can lead to anemia, worsening…”
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302-OR: The Antimyostatin Antibody SRK-439 Promotes Healthy Body Composition in Combination with GLP-1RAs in a Mouse Model of Obesity by Fulham, Melissa A, Chapron, Christopher, Danehy, Francis T, Streich, Frederick C, Liang, Brian, Boston, Christopher J, Jackson, Justin W, Huang, Yan, Nicholls, Samantha EB, Cortes, Leslie, Qatanani, Mo

“…One of the challenges with obesity treatments is maintaining a healthy body composition during weight loss; lean mass is reduced during weight loss (15%-40% of…”
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The HECT Domain and RCC1‐like Domain 5/Herc5 Protein Exhibits Intrinsic Ubiquitin Ligase Activity by Ronchi, Virginia P, Klein, Jennifer, Streich, Frederick, Haas, Arthur

“…Abstract only HERC5 is a Type1 interferon‐induced Hect ligase having an essential role in the cellular innate immune response to viral and inflammatory…”
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Characterization of Trim32‐catalyzed polyubiquitin chain formation by Streich, Frederick C, Haas, Arthur L

“…Abstract only…”
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Capturing a substrate in an activated RING E3/E2SUMO complex by Streich Jr, Frederick C, Lima, Christopher D

“…Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin-like modifier (SUMO) regulates processes…”
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Carboxylic acid functionalized cobalt(III) cyclen complexes for catalytic hydrolysis of phosphodiester bonds by Knight, D Andrew, Delehanty, James B, Goldman, Ellen R, Bongard, Jason, Streich, Frederick, Edwards, Laura W, Chang, Eddie L

“…4-(1,4,7,10-Tetraazacyclotetradec-1-yl)methylbenzoic acid (cycmba, 1) has been synthesized, as a step towards the eventual development of sequence-specific…”
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Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015 by Dagbay, Kevin B, Treece, Erin, Streich, Jr, Frederick C, Jackson, Justin W, Faucette, Ryan R, Nikiforov, Anastasia, Lin, Susan C, Boston, Chris J, Nicholls, Samantha B, Capili, Allan D, Carven, Gregory J

“…Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates…”
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Monofunctionalized Tetraazacrowns for Use in Bioconjugation and Catalysis by Bongard, Jason E., Hartsock, Robert W., Stegbauer, William D., Streich, Frederick C., Barnum, Rider, Chang, Eddie L., Knight, D. Andrew

“…Alkylation of 1,4,7,11-tetraazacyclododecane (cyclen) with 4-nitrobenzyl bromide, p-chloromethylbenzyl alcohol, 4-iodobenzyl bromide, or 4-vinylbenzyl bromide…”
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