Search Results - "Strefford, J C"

Recurrent mutations refine prognosis in chronic lymphocytic leukemia by Baliakas, P, Hadzidimitriou, A, Sutton, L-A, Rossi, D, Minga, E, Villamor, N, Larrayoz, M, Kminkova, J, Agathangelidis, A, Davis, Z, Tausch, E, Stalika, E, Kantorova, B, Mansouri, L, Scarfò, L, Cortese, D, Navrkalova, V, Rose-Zerilli, M J J, Smedby, K E, Juliusson, G, Anagnostopoulos, A, Makris, A M, Navarro, A, Delgado, J, Oscier, D, Belessi, C, Stilgenbauer, S, Ghia, P, Pospisilova, S, Gaidano, G, Campo, E, Strefford, J C, Stamatopoulos, K, Rosenquist, R

“…Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 ( n…”
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Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation by Martínez, N, Almaraz, C, Vaqué, J P, Varela, I, Derdak, S, Beltran, S, Mollejo, M, Campos-Martin, Y, Agueda, L, Rinaldi, A, Kwee, I, Gut, M, Blanc, J, Oscier, D, Strefford, J C, Martinez-Lopez, J, Salar, A, Sole, F, Rodriguez-Peralto, J L, Diez-Tascón, C, García, J F, Fraga, M, Sebastián, E, Alvés, J, Menárguez, J, González-Carreró, J, Casado, L F, Bayes, M, Bertoni, F, Gut, I, Piris, M A

“…Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic…”
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Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2 by Strefford, J C, Sutton, L-A, Baliakas, P, Agathangelidis, A, Malčíková, J, Plevova, K, Scarfó, L, Davis, Z, Stalika, E, Cortese, D, Cahill, N, Pedersen, L B, di Celle, P F, Tzenou, T, Geisler, C, Panagiotidis, P, Langerak, A W, Chiorazzi, N, Pospisilova, S, Oscier, D, Davi, F, Belessi, C, Mansouri, L, Ghia, P, Stamatopoulos, K, Rosenquist, R

“…Recent studies have revealed recurrent mutations of the NOTCH1 , SF3B1 and BIRC3 genes in chronic lymphocytic leukemia (CLL), especially among aggressive,…”
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13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia by Parker, H, Rose-Zerilli, M J J, Parker, A, Chaplin, T, Wade, R, Gardiner, A, Griffiths, M, Collins, A, Young, B D, Oscier, D G, Strefford, J C

“…Historically, genes targeted by recurrent chromosomal deletions have been identified within the smallest genomic region shared in all patients, the minimally…”
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miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer by Cellura, D, Pickard, K, Quaratino, S, Parker, H, Strefford, J C, Thomas, G J, Mitter, R, Mirnezami, A H, Peake, N J

“…Transglutaminase-2 (TG2) is a critical cross-linking enzyme in the extracellular matrix (ECM) and tumor microenvironment (TME). Although its expression has…”
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Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia by Parker, H, Rose-Zerilli, M J J, Larrayoz, M, Clifford, R, Edelmann, J, Blakemore, S, Gibson, J, Wang, J, Ljungström, V, Wojdacz, T K, Chaplin, T, Roghanian, A, Davis, Z, Parker, A, Tausch, E, Ntoufa, S, Ramos, S, Robbe, P, Alsolami, R, Steele, A J, Packham, G, Rodríguez-Vicente, A E, Brown, L, McNicholl, F, Forconi, F, Pettitt, A, Hillmen, P, Dyer, M, Cragg, M S, Chelala, C, Oakes, C C, Rosenquist, R, Stamatopoulos, K, Stilgenbauer, S, Knight, S, Schuh, A, Oscier, D G, Strefford, J C

“…Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and are disrupted at the genomic level in a spectrum of human…”
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Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial by Strefford, J C, Kadalayil, L, Forster, J, Rose-Zerilli, M J J, Parker, A, Lin, T T, Heppel, N, Norris, K, Gardiner, A, Davies, Z, Gonzalez de Castro, D, Else, M, Steele, A J, Parker, H, Stankovic, T, Pepper, C, Fegan, C, Baird, D, Collins, A, Catovsky, D, Oscier, D G

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Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization by STREFFORD, J. C, WORLEY, H, GRIFFITHS, M, HING, S, ROSS, F. M, TALLEY, P, SAHA, V, MOORMAN, A. V, HARRISON, C. J, BARBER, K, WRIGHT, S, STEWART, A. R. M, ROBINSON, H. M, BETTNEY, G, VAN DELFT, F. W, ATHERTON, M. G, DAVIES, T

“…Chromosomal abnormalities are important for the classification and risk stratification of patients with acute lymphoblastic leukemia (ALL). However,…”
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Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy by An, Q, Burke, G A A, Dainton, M, Harrison, C J, Kempski, H, Konn, Z, Myooren, W, Stewart, A, Taj, M, Webb, D, Strefford, J C, Martineau, M

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Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia by Allan, J M, Sunter, N J, Bailey, J R, Pettitt, A R, Harris, R J, Pepper, C, Fegan, C, Hall, A G, Deignan, L, Bacon, C M, Pointon, J C, Houlston, R S, Broderick, P, Mainou-Fowler, T, Jackson, G H, Summerfield, G, Evans, P A, Strefford, J C, Parker, A, Oscier, D, Pratt, G, Allsup, D J

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The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1 by Larrayoz, M, Blakemore, S J, Dobson, R C, Blunt, M D, Rose-Zerilli, M J J, Walewska, R, Duncombe, A, Oscier, D, Koide, K, Forconi, F, Packham, G, Yoshida, M, Cragg, M S, Strefford, J C, Steele, A J

“…The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukaemia (CLL), with high expression correlated with progressive disease. The…”
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Disruption of ETV6 in intron 2 results in upregulatory and insertional events in childhood acute lymphoblastic leukaemia by Jalali, G R, An, Q, Konn, Z J, Worley, H, Wright, S L, Harrison, C J, Strefford, J C, Martineau, M

“…We describe four cases of childhood B-cell progenitor acute lymphoblastic leukaemia (BCP-ALL) and one of T-cell (T-ALL) with unexpected numbers of interphase…”
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Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia by ROBINSON, H. M, MARTINEAU, M, HARRIS, R. L, BARBER, K. E, JALALI, G. R, MOORMAN, A. V, STREFFORD, J. C, BROADFIELD, Z. J, CHEUNG, K. L, HARRISON, C. J

“…Deletions from the derivative chromosome 9, der(9), of the translocation, t(9;22)(q34;q11), at the site of the ABL/BCR fusion gene, have been demonstrated by…”
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Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial by Larrayoz, M, Rose-Zerilli, M J J, Kadalayil, L, Parker, H, Blakemore, S, Forster, J, Davis, Z, Steele, A J, Collins, A, Else, M, Catovsky, D, Oscier, D G, Strefford, J C

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Lamin B1 regulates somatic mutations and progression of B-cell malignancies by Klymenko, T, Bloehdorn, J, Bahlo, J, Robrecht, S, Akylzhanova, G, Cox, K, Estenfelder, S, Wang, J, Edelmann, J, Strefford, J C, Wojdacz, T K, Fischer, K, Hallek, M, Stilgenbauer, S, Cragg, M, Gribben, J, Braun, A

“…Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA…”
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Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease by Rose-Zerilli, M J J, Gibson, J, Wang, J, Tapper, W, Davis, Z, Parker, H, Larrayoz, M, McCarthy, H, Walewska, R, Forster, J, Gardiner, A, Steele, A J, Chelala, C, Ennis, S, Collins, A, Oakes, C C, Oscier, D G, Strefford, J C

“…The biological features of IGHV-M chronic lymphocytic leukemia responsible for disease progression are still poorly understood. We undertook a longitudinal…”
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Amplification of the ABL gene in T-cell acute lymphoblastic leukemia by Barber, K E, Martineau, M, Harewood, L, Stewart, M, Cameron, E, Strefford, J C, Rutherford, S, Allen, T D, Broadfield, Z J, Cheung, K L, Harris, R L, Jalali, G R, Moorman, A V, Robinson, H M, Harrison, C J

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P624: CHROMOTHRIPSIS IN PATIENTS WITH CLL AND COMPLEX KARYOTYPE: PATTERNS OF ABERRATIONS AND PROGNOSTIC VALUE by Ramos‐Campoy, S., Puiggros, A., Kamaso, J., Beà, S., Bougeon, S., Larráyoz, M. J., Costa, D., Parker, H., Rigolin, G. M., Blanco, M. L., Collado, R., Ancín, I., Salgado, R., Moro, M., Baumann, T., Gimeno, E., Moreno, C., Calasanz, M. J., Cuneo, A., Strefford, J. C., Nguyen‐Khac, F., Oscier, D., Haferlach, C., Schoumans, J., Espinet, B.

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Molecular characterisation of the t(1;15)(p22;q22) translocation in the prostate cancer cell line LNCaP by Strefford, J C, Lane, T M, Hill, A, LeRoux, L, Foot, N J, Shipley, J, Oliver, R T D, Lu, Y-J, Young, B D

“…Although chromosome translocations are well-documented recurrent events in hematological malignancies and soft tissue sarcomas, their significance in…”
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The characterisation of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH by Strefford, J C, Foot, N J, Chaplin, T, Neat, M J, Oliver, R T, Young, B D, Jones, L K

“…The cell line U937, which has been used extensively for studies of myeloid differentiation, bears the t(10;11)(p13;q14) translocation which results in a fusion…”
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