Search Results - "Street, I P"

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi by Holloway, G.A., Parisot, J.P., Novello, P.M., Watson, K.G., Armstrong, T., Thompson, R.C.A., Street, I.P., Baell, J.B.

“…A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation determined that no part of the…”
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2-Deoxy-2-fluoro-D-glycosyl fluorides. A new class of specific mechanism-based glycosidase inhibitors by Withers, S G, Rupitz, K, Street, I P

“…Mechanism-based glycosidase inhibitors are of considerable use in studies of enzyme mechanism, in studies of glycoprotein processing, and possibly…”
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Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline by Pruzanski, W, Greenwald, R A, Street, I P, Laliberte, F, Stefanski, E, Vadas, P

“…Extracellular phospholipases A2 play an important role in articular and extra-articular inflammatory processes. Secretory non-pancreatic phospholipase A2…”
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Inactivation of a .beta.-glucosidase through the accumulation of a stable 2-deoxy-2-fluoro-.alpha.-D-glucopyranosyl-enzyme intermediate: a detailed investigation by Street, Ian P, Kempton, Julie B, Withers, Stephen G

“…The inactivation of glycosidases by 2-deoxy-2-fluoroglycosides has been shown previously to occur via the accumulation of a covalent…”
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Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae by ANDERSON, M. S, MUEHLBACHER, M, STREET, I. P, PROFFITT, J, POULTER, C. D

“…Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) is an enzyme in the isoprenoid biosynthetic pathway which catalyzes the…”
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Unequivocal demonstration of the involvement of a glutamate residue as a nucleophile in the mechanism of a retaining glycosidase by Withers, Stephen G, Warren, R. Antony J, Street, Ian P, Rupitz, Karen, Kempton, Julie B, Aebersold, Ruedi

“…The exact nature of the involvement of aspartic acid and glutamic acid residues in catalysis by glycosidases has been a matter of considerable debate for some…”
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Hydrogen bonding and specificity. Fluorodeoxy sugars as probes of hydrogen bonding in the glycogen phosphorylase-glucose complex by Street, Ian P, Armstrong, Charles R, Withers, Stephen G

“…The affinities of a large number of deoxy and fluorodeoxy sugars for the glucose binding site in glycogen phosphorylase have been measured, and polarities and…”
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Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2 by Street, Ian P, Lin, Hung Kuei, Laliberte, France, Ghomashchi, Farideh, Wang, Zhaoyin, Perrier, Helene, Tremblay, Nathalie M, Huang, Zheng, Weech, Philip K, Gelb, Michael H

“…A trifluoromethyl ketone analogue of arachidonic acid in which the COOH group is replaced with COCF3 (AACOCF3) was prepared and found to be a tight- and…”
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Identification of Cys139 and Glu207 As Catalytically Important Groups in the Active Site of Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase by Street, Ian P, Coffman, Hazel R, Poulter, C. Dale, Baker, Jonathan A

“…Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (EC 5.3.3.2) catalyzes the antarafacial [1.3] allylic rearrangement of isopentenyl diphosphate…”
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Probing the ionization state of substrate alpha-D-glucopyranosyl phosphate bound to glycogen phosphorylase b by Street, I P, Withers, S G

“…The ionization state of the substrate alpha-D-glucopyranosyl phosphate bound at the active site of glycogen phosphorylase has been probed by a number of…”
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Isopentenyldiphosphate:dimethylallyldiphosphate isomerase: construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile by Street, Ian P, Poulter, C. Dale

“…Isopentenyldiphosphate:dimethylallyldiphosphate isomerase (IPP isomerase) is an enzyme in isoprene metabolism which catalyzes the interconversion of the…”
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NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2 by Trimble, Laird A, Street, Ian P, Perrier, Helene, Tremblay, Nathalie M, Weech, Philip K, Bernstein, Michael A

“…Arachidonyl trifluoromethyl ketone (AACOCF3) is a slow- and tight-binding inhibitor of the human cytosolic phospholipase A2 (cPLA2) [Street et al. (1993)…”
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Identification of a covalent .alpha.-D-glucopyranosyl enzyme intermediate formed on a .beta.-glucosidase by Withers, Stephen G, Street, Ian P

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Substituted glycals as probes of glycosidase mechanisms by Lai, Ellen C.K., Morris, Sandra A., Street, Ian P., Withers, Stephen G.

“…d-Glucal and a series of substituted derivatives have been tested as substrates, inhibitors and inactivators of the Agrobacterium faecalis β-glucosidase in…”
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Fluorinated and deoxygenated substrates as probes of transition state structure in glycogen phosphorylase by Street, Ian P, Rupitz, Karen, Withers, Stephen G

“…A series of deoxyfluoro- and deoxy-alpha-D-glucopyranosyl phosphates have been tested as substrates of rabbit muscle glycogen phosphorylase b. All are found to…”
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Hydrogen exchange during the enzyme-catalyzed isomerization of isopentenyl diphosphate and dimethylallyl diphosphate by Street, Ian P, Christensen, Dale J, Poulter, C. Dale

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Interfacial catalysis and production of a high ratio of leukotriene A4 to 5-HPETE by 5-lipoxygenase in a coupled assay with phospholipase A2 by Riendeau, D, Falgueyret, J P, Meisner, D, Sherman, M M, Laliberté, F, Street, I P

“…The activity of purified 5-lipoxygenases (5-LO) shows a requirement for the presence of phosphatidylcholine or other lipids, in addition to Ca2+ and ATP. The…”
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A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2 by Huang, Z, Laliberté, F, Tremblay, N M, Weech, P K, Street, I P

“…A sensitive method for continuously monitoring the activity of the human cytosolic phospholipase A2 (cPLA2) is described. Recombinant cPLA2 efficiently…”
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Isopentenyldiphosphate : dimethylallyl-diphosphate isomerase: Construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile by Street, I P, Poulter, C D

“…Isopentenyldiphosphate : dimethylallyl-diphosphate isomerase (IPP isomerase) is an enzyme in isoprene metabolism which catalyzes the interconversion of the…”
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Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A sub(2), blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets by Riendeau, D, Guay, J, Weech, P K, Laliberte, F, Yergey, J, Li, Chun, Desmarais, S, Perrier, H, Liu, S, Nicoll-Griffith, D, Street, I P

“…Arachidonyl trifluoromethyl ketone (AACOCF sub(3)) is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A sub(2) (cPLA…”
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