Search Results - "Strecker, Jan"

Neutrophils in aging and aging‐related pathologies by Van Avondt, Kristof, Strecker, Jan‐Kolja, Tulotta, Claudia, Minnerup, Jens, Schulz, Christian, Soehnlein, Oliver

“…Summary Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European…”
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Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents by Schmidt‐Pogoda, Antje, Bonberg, Nadine, Koecke, Mailin Hannah Marie, Strecker, Jan‐Kolja, Wellmann, Jürgen, Bruckmann, Nils‐Martin, Beuker, Carolin, Schäbitz, Wolf‐Rüdiger, Meuth, Sven G., Wiendl, Heinz, Minnerup, Heike, Minnerup, Jens

“…Objective To analyze why numerous acute stroke treatments were successful in the laboratory but failed in large clinical trials. Methods We searched all phase…”
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Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges by Schafflick, David, Wolbert, Jolien, Heming, Michael, Thomas, Christian, Hartlehnert, Maike, Börsch, Anna-Lena, Ricci, Alessio, Martín-Salamanca, Sandra, Li, Xiaolin, Lu, I-Na, Pawlak, Mathias, Minnerup, Jens, Strecker, Jan-Kolja, Seidenbecher, Thomas, Meuth, Sven G., Hidalgo, Andres, Liesz, Arthur, Wiendl, Heinz, Meyer zu Horste, Gerd

“…The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings suggest that these CNS-associated border tissues have complex immunological…”
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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia by Beuker, Carolin, Schafflick, David, Strecker, Jan-Kolja, Heming, Michael, Li, Xiaolin, Wolbert, Jolien, Schmidt-Pogoda, Antje, Thomas, Christian, Kuhlmann, Tanja, Aranda-Pardos, Irene, A-Gonzalez, Noelia, Kumar, Praveen Ashok, Werner, Yves, Kilic, Ertugrul, Hermann, Dirk M., Wiendl, Heinz, Stumm, Ralf, Meyer zu Hörste, Gerd, Minnerup, Jens

“…Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the…”
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Stroke in Patients with Bacterial Meningitis: A Cohort Study and Meta‐Analysis by Beuker, Carolin, Werring, Nils, Bonberg, Nadine, Strecker, Jan‐Kolja, Schmidt‐Pogoda, Antje, Schwindt, Wolfram, Stracke, Paul, Schulte‐Mecklenbeck, Andreas, Gross, Catharina, Wiendl, Heinz, Minnerup, Heike, Minnerup, Jens

“…Objective The purpose of this study was to characterize patients with ischemic stroke due to bacterial meningitis. Methods In a single‐center retrospective…”
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Neutrophil granulocytes in cerebral ischemia – Evolution from killers to key players by Strecker, Jan-Kolja, Schmidt, Antje, Schäbitz, Wolf-Rüdiger, Minnerup, Jens

“…Neutrophil granulocytes (or polymorphonuclear cells, PMNs) have long been considered as crude killing machines, particularly trained to attack bacterial or…”
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Characterization of Extracranial Giant Cell Arteritis with Intracranial Involvement and its Rapidly Progressive Subtype by Beuker, Carolin, Wankner, Maximilian Christian, Thomas, Christian, Strecker, Jan‐Kolja, Schmidt‐Pogoda, Antje, Schwindt, Wolfram, Schulte‐Mecklenbeck, Andreas, Gross, Catharina, Wiendl, Heinz, Barth, Peter J., Eckert, Bernd, Meinel, Thomas Raphael, Arnold, Marcel, Schaumberg, Jens, Krüger, Schulamith, Deb‐Chatterji, Milani, Magnus, Tim, Röther, Joachim, Minnerup, Jens

“…Objective The objective of this study was to characterize patients with extracranial giant cell arteritis with intracranial involvement. Methods In a…”
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Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1 by Petzold, Tobias, Thienel, Manuela, Dannenberg, Lisa, Mourikis, Philipp, Helten, Carolin, Ayhan, Aysel, M’Pembele, René, Achilles, Alina, Trojovky, Kajetan, Konsek, Daniel, Zhang, Zhe, Regenauer, Ron, Pircher, Joachim, Ehrlich, Andreas, Lüsebrink, Enzo, Nicolai, Leo, Stocker, Thomas J., Brandl, Richard, Röschenthaler, Franz, Strecker, Jan, Saleh, Inas, Spannagl, Michael, Mayr, Christoph H., Schiller, Herbert B., Jung, Christian, Gerdes, Norbert, Hoffmann, Till, Levkau, Bodo, Hohlfeld, Thomas, Zeus, Tobias, Schulz, Christian, Kelm, Malte, Polzin, Amin

“…A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban…”
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Dietary salt promotes ischemic brain injury and is associated with parenchymal migrasome formation by Schmidt-Pogoda, Antje, Strecker, Jan-Kolja, Liebmann, Marie, Massoth, Christina, Beuker, Carolin, Hansen, Uwe, König, Simone, Albrecht, Sarah, Bock, Stefanie, Breuer, Johanna, Sommer, Clemens, Schwab, Nicholas, Wiendl, Heinz, Klotz, Luisa, Minnerup, Jens

“…Sodium chloride promotes vascular fibrosis, arterial hypertension, pro-inflammatory immune cell polarization and endothelial dysfunction, all of which might…”
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Anti-LINGO-1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke by Strecker, Jan-Kolja, Schmidt-Pogoda, Antje, Diederich, Kai, Zaremba, Dario, Wieters, Frederique, Beuker, Carolin, Koecke, Mailin Hannah Marie, Straeten, Frederike Anne, Wiendl, Heinz, Minnerup, Jens

“…Demyelination of corticospinal tract neurons contributes to long-term disability after cortical stroke. Nonetheless, poststroke myelin loss has not been…”
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Inhibition of leukocyte migration after ischemic stroke by VE‐cadherin mutation in a mouse model leads to reduced infarct volumes and improved motor skills by Koecke, Mailin Hannah Marie, Strecker, Jan‐Kolja, Straeten, Frederike Anne, Beuker, Carolin, Minnerup, Jens, Schmidt‐Pogoda, Antje

“…Aims To distinguish between the genuine cellular impact of the ischemic cascade by leukocytes and unspecific effects of edema and humoral components, two…”
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Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke by Schmidt, Antje, Strecker, Jan-Kolja, Hucke, Stephanie, Bruckmann, Nils-Martin, Herold, Martin, Mack, Matthias, Diederich, Kai, Schäbitz, Wolf-Rüdiger, Wiendl, Heinz, Klotz, Luisa, Minnerup, Jens

“…BACKGROUND AND PURPOSE—Peripheral immune cell infiltration contributes to neural injury after ischemic stroke. However, in contrast to lymphocytes and…”
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Defining mechanisms of neural plasticity after brainstem ischemia in rats by Minnerup, Jens, Strecker, Jan‐Kolja, Wachsmuth, Lydia, Hoppen, Maike, Schmidt, Antje, Hermann, Dirk M., Wiendl, Heinz, Meuth, Sven, Faber, Cornelius, Diederich, Kai, Schäbitz, Wolf‐Rüdiger

“…Objective Neurological recovery after stroke mainly depends on the location of the lesion. A substantial portion of strokes affects the brainstem. However,…”
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Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice by Schiffmann, Daniel, Lampkemeyer, Victoria, Lindner, Maren, Fleck, Ann-Katrin, Koch, Kathrin, Eschborn, Melanie, Liebmann, Marie, Strecker, Jan-Kolja, Minnerup, Jens, Wiendl, Heinz, Klotz, Luisa

“…Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease causing axonal degeneration and demyelination. Exercise in mice with active monophasic…”
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Bcl6 controls meningeal Th17–B cell interaction in murine neuroinflammation by Hartlehnert, Maike, Börsch, Anna-Lena, Li, Xiaolin, Burmeister, Miriam, Gerwien, Hanna, Schafflick, David, Heming, Michael, Lu, I-Na, Narayanan, Venu, Strecker, Jan-Kolja, Kolz, Anna, Peters, Anneli, Wu, Gregory F., Wiendl, Heinz, Sorokin, Lydia, Horste, Gerd Meyer zu

“…Ectopic lymphoid tissue containing B cells forms in the meninges at late stages of human multiple sclerosis (MS) and when neuroinflammation is induced by…”
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Immune Cell Infiltration into the Brain After Ischemic Stroke in Humans Compared to Mice and Rats: a Systematic Review and Meta-Analysis by Beuker, Carolin, Strecker, Jan-Kolja, Rawal, Rajesh, Schmidt-Pogoda, Antje, Ruck, Tobias, Wiendl, Heinz, Klotz, Luisa, Schäbitz, Wolf-Rüdiger, Sommer, Clemens J., Minnerup, Heike, Meuth, Sven G., Minnerup, Jens

“…Although several studies have suggested that anti-inflammatory strategies reduce secondary infarct growth in animal stroke models, clinical studies have not…”
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The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice by Schilling, Matthias, Strecker, Jan-Kolja, Ringelstein, E. Bernd, Schäbitz, Wolf-Rüdiger, Kiefer, Reinhard

“…Abstract The chemokine receptor 2 (CCR2) is involved in inflammatory reactions following cerebral ischemia. Monocyte chemoattractant protein-1 (MCP-1) binds…”
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Meta-Analysis of the Efficacy of Different Training Strategies in Animal Models of Ischemic Stroke by SCHMIDT, Antje, WELLMANN, Jürgen, SCHILLING, Matthias, STRECKER, Jan-Kolja, SOMMER, Clemens, SCHÄBITZ, Wolf-Rüdiger, DIEDERICH, Kai, MINNERUP, Jens

“…Although several studies have shown beneficial effects of training in animal stroke models, the most effective training strategy and the optimal time to…”
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Monocyte Chemoattractant Protein-1―Deficiency Results in Altered Blood―Brain Barrier Breakdown After Experimental Stroke by STRECKER, Jan-Kolja, MINNERUP, Jens, SCHÜTTE-NÜTGEN, Katharina, GESS, Burkhard, SCHÄBITZ, Wolf-Rüdiger, SCHILLING, Matthias

“…Stroke-induced blood-brain barrier (BBB)-disruption can contribute to further progression of cerebral damage. There is rising evidence for a strong involvement…”
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The dilemma of neuroprotection trials in times of successful endovascular recanalization by Schmidt-Pogoda, Antje, Kaesmacher, Johannes, Bonberg, Nadine, Werring, Nils, Strecker, Jan-Kolja, Koecke, Mailin Hannah Marie, Beuker, Carolin, Gralla, Jan, Meier, Raphael, Wiendl, Heinz, Minnerup, Heike, Fischer, Urs, Minnerup, Jens

“…The "translational roadblock" between successful animal stroke studies and neutral clinical trials is usually attributed to conceptual weaknesses. However, we…”
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