Search Results - "Strauss, Kenneth I."

Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury by Birnie, Matthew, Morrison, Ryan, Camara, Ramatoulie, Strauss, Kenneth I

“…Traumatic brain injury (TBI) induces arachidonic acid (ArA) release from cell membranes. ArA metabolites form a class of over 50 bioactive eicosanoids that can…”
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Hypoxia-Ischemia Induces DNA Synthesis without Cell Proliferation in Dying Neurons in Adult Rodent Brain by Kuan, Chia-Yi, Schloemer, Aryn J, Lu, Aigang, Burns, Kevin A, Weng, Wei-Lan, Williams, Michael T, Strauss, Kenneth I, Vorhees, Charles V, Flavell, Richard A, Davis, Roger J, Sharp, Frank R, Rakic, Pasko

“…Recent studies suggest that postmitotic neurons can reenter the cell cycle as a prelude to apoptosis after brain injury. However, most dying neurons do not…”
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Hypoxic Preconditioning Protects against Ischemic Brain Injury by Sharp, Frank R., Ran, Ruiqiong, Lu, Aigang, Tang, Yang, Strauss, Kenneth I., Glass, Todd, Ardizzone, Tim, Bernaudin, Myriam

“…Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are protected against cerebral and cardiac ischemia between 1 and 2 days…”
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A liquid chromatography/mass spectrometric method for simultaneous analysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and epoxyeicosatrienoic acids in rat brain tissue by Yue, Hongfei, Jansen, Susan A., Strauss, Kenneth I., Borenstein, Michael R., Barbe, Mary F., Rossi, Luella J., Murphy, Elise

“…A sensitive, specific, and robust liquid chromatography/mass spectrometric (LC/MS) method was developed and validated that allows simultaneous analysis of…”
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Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy by Strauss, Kenneth I, Elisevich, Kost V

“…Epilepsy patients have distinct immune/inflammatory cell profiles and inflammatory mediator levels in the blood. Although the neural origin of inflammatory…”
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Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain by Strauss, Kenneth I

“…Abstract Overexpression of COX2 appears to be both a marker and an effector of neural damage after a variety of acquired brain injuries, and in natural or…”
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Determination of bioactive eicosanoids in brain tissue by a sensitive reversed-phase liquid chromatographic method with fluorescence detection by Yue, Hongfei, Strauss, Kenneth I, Borenstein, Michael R, Barbe, Mary F, Rossi, Luella J, Jansen, Susan A

“…Arachidonic acid (AA) is metabolized to prostaglandins (PGs) via cyclooxygenases (COX) catalysis, and to epoxyeicosatrienoic acids (EETs),…”
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Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat by Strauss, K I, Barbe, M F, Marshall, R M, Raghupathi, R, Mehta, S, Narayan, R K

“…Cyclooxygenase-2 (COX2) is a primary inflammatory mediator that converts arachidonic acid into precursors of vasoactive prostaglandins, producing reactive…”
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COX2 inhibitors for acquired brain injuries: Is the time ripe? by Strauss, Kenneth I

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Combined age- and trauma-related proteomic changes in rat neocortex: a basis for brain vulnerability by Mehan, Neal D, Strauss, Kenneth I

“…Abstract This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and…”
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Polyamine catabolism is enhanced after traumatic brain injury by Zahedi, Kamyar, Huttinger, Francis, Morrison, Ryan, Murray-Stewart, Tracy, Casero, Robert A, Strauss, Kenneth I

“…Polyamines spermine and spermidine are highly regulated, ubiquitous aliphatic cations that maintain DNA structure and function as immunomodulators and as…”
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Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury by Gopez, Jonas J, Yue, Hongfei, Vasudevan, Ram, Malik, Amir S, Fogelsanger, Lester N, Lewis, Shawn, Panikashvili, David, Shohami, Esther, Jansen, Susan A, Narayan, Raj K, Strauss, Kenneth I

“…Increases in brain cyclooxygenase-2 (COX2) are associated with the central inflammatory response and with delayed neuronal death, events that cause secondary…”
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A simple, efficient tool for assessment of mice after unilateral cortex injury by Shelton, Shirley B., Pettigrew, David B., Hermann, Alison D., Zhou, Weidong, Sullivan, Patrick M., Crutcher, Keith A., Strauss, Kenneth I.

“…A refined battery of neurological tests, SNAP (Simple Neuroassessment of Asymmetric Impairment), was developed and validated to efficiently assess neurological…”
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Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death by Strauss, Kenneth I, Marini, Ann M

“…Primary insults to the brain can initiate glutamate release that may result in excitotoxicity followed by neuronal cell death. This secondary process is…”
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Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: Effects of traumatic brain injury by Strauss, Kenneth I., Gruzdev, Artiom, Zeldin, Darryl C.

“…► Ephx2-KO had better beam walk performance than wild-type mice before and after TBI. ► Ephx2-KO mice had impaired performance in the Morris water maze…”
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N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway by Zhu, Daming, Wu, Xuan, Strauss, Kenneth I., Lipsky, Robert H., Qureshi, Zehra, Terhakopian, Artin, Novelli, Antonello, Banaudha, Krishna, Marini, Ann M.

“…N‐Methyl‐D‐aspartate (NMDA) at a subtoxic concentration (100 μM) promotes neuronal survival against glutamate‐mediated excitotoxicity via a brain‐derived…”
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N-methyl-D-aspartate and TrkB receptor activation in cerebellar granule cells: an in vitro model of preconditioning to stimulate intrinsic survival pathways in neurons by Jiang, Xueying, Zhu, Daming, Okagaki, Peter, Lipsky, Robert, Wu, Xuan, Banaudha, Krishna, Mearow, Karen, Strauss, Kenneth I, Marini, Ann M

“…Delineating the mechanisms of survival pathways that exist in neurons will provide important insight into how neurons utilize intracellular proteins as…”
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Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat by Raghupathi, Ramesh, Strauss, Kenneth I, Zhang, Chen, Krajewski, Stanislaw, Reed, John C, McIntosh, Tracy K

“…Cell death/survival following CNS injury may be a result of alterations in the intracellular ratio of death and survival factors. Using immunohistochemistry,…”
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A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model by Malik, Amir S, Narayan, Raj K, Wendling, Woodrow W, Cole, Russell W, Pashko, Laura L, Schwartz, Arthur G, Strauss, Kenneth I

“…The purpose of this study was to investigate the efficacy of a novel steroid, fluasterone (DHEF, a dehydroepiandrosterone (DHEA) analog), at improving…”
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Common patterns of bcl-2 family gene expression in two traumatic brain injury models by Strauss, Kenneth I, Narayan, Raj K, Raghupathi, Ramesh

“…Cell death/survival following traumatic brain injury (TBI) may be a result of alterations in the intracellular ratio of death and survival factors. Bcl-2…”
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