Search Results - "Strausberg, Robert"

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer by Tie, Jeanne, Wang, Yuxuan, Tomasetti, Cristian, Li, Lu, Springer, Simeon, Kinde, Isaac, Silliman, Natalie, Tacey, Mark, Wong, Hui-Li, Christie, Michael, Kosmider, Suzanne, Skinner, Iain, Wong, Rachel, Steel, Malcolm, Tran, Ben, Desai, Jayesh, Jones, Ian, Haydon, Andrew, Hayes, Theresa, Price, Tim J, Strausberg, Robert L, Diaz, Jr, Luis A, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert, Gibbs, Peter

“…Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may identify patients at the highest risk of recurrence and help inform…”
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Evaluation of next generation sequencing platforms for population targeted sequencing studies by Harismendy, Olivier, Ng, Pauline C, Strausberg, Robert L, Wang, Xiaoyun, Stockwell, Timothy B, Beeson, Karen Y, Schork, Nicholas J, Murray, Sarah S, Topol, Eric J, Levy, Samuel, Frazer, Kelly A

“…Next generation sequencing (NGS) platforms are currently being utilized for targeted sequencing of candidate genes or genomic intervals to perform…”
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Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer by Hon, Gary C, Hawkins, R David, Caballero, Otavia L, Lo, Christine, Lister, Ryan, Pelizzola, Mattia, Valsesia, Armand, Ye, Zhen, Kuan, Samantha, Edsall, Lee E, Camargo, Anamaria Aranha, Stevenson, Brian J, Ecker, Joseph R, Bafna, Vineet, Strausberg, Robert L, Simpson, Andrew J, Ren, Bing

“…While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations during tumorigenesis including aberrant DNA hypermethylation…”
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Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer by MOURADOV, Dmitri, SLOGGETT, Clare, O'CONNOR, Liam, WILDING, Jennifer L, BICKNELL, David, TOMLINSON, Ian P. M, BODMER, Walter F, MARIADASON, John M, SIEBER, Oliver M, JORISSEN, Robert N, LOVE, Christopher G, SHAN LI, BURGESS, Antony W, ARANGO, Diego, STRAUSBERG, Robert L, BUCHANAN, Daniel, WORMALD, Samuel

“…Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental therapy, and biomarkers. However, to what extent these…”
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Integrated Genomic Analysis of Human Glioblastoma Multiforme by Parsons, D. Williams, Jones, Siân, Zhang, Xiaosong, Lin, Jimmy Cheng-Ho, Leary, Rebecca J, Angenendt, Philipp, Mankoo, Parminder, Carter, Hannah, Siu, I. Mei, Gallia, Gary L, Olivi, Alessandro, McLendon, Roger, Rasheed, B. Ahmed, Keir, Stephen, Nikolskaya, Tatiana, Nikolsky, Yuri, Busam, Dana A, Tekleab, Hanna, Diaz, Luis A. Jr, Hartigan, James, Smith, Doug R, Strausberg, Robert L, Marie, Suely Kazue Nagahashi, Shinjo, Sueli Mieko Oba, Yan, Hai, Riggins, Gregory J, Bigner, Darell D, Karchin, Rachel, Papadopoulos, Nick, Parmigiani, Giovanni, Vogelstein, Bert, Velculescu, Victor E, Kinzler, Kenneth W

“…Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein…”
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Genetic variation in an individual human exome by Ng, Pauline C, Levy, Samuel, Huang, Jiaqi, Stockwell, Timothy B, Walenz, Brian P, Li, Kelvin, Axelrod, Nelson, Busam, Dana A, Strausberg, Robert L, Venter, J Craig

“…There is much interest in characterizing the variation in a human individual, because this may elucidate what contributes significantly to a person's…”
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Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome by Venkatesh, Byrappa, Kirkness, Ewen F, Loh, Yong-Hwee, Halpern, Aaron L, Lee, Alison P, Johnson, Justin, Dandona, Nidhi, Viswanathan, Lakshmi D, Tay, Alice, Venter, J Craig, Strausberg, Robert L, Brenner, Sydney

“…Owing to their phylogenetic position, cartilaginous fishes (sharks, rays, skates, and chimaeras) provide a critical reference for our understanding of…”
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The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific by Rusch, Douglas B, Halpern, Aaron L, Sutton, Granger, Heidelberg, Karla B, Williamson, Shannon, Yooseph, Shibu, Wu, Dongying, Eisen, Jonathan A, Hoffman, Jeff M, Remington, Karin, Beeson, Karen, Tran, Bao, Smith, Hamilton, Baden-Tillson, Holly, Stewart, Clare, Thorpe, Joyce, Freeman, Jason, Andrews-Pfannkoch, Cynthia, Venter, Joseph E, Li, Kelvin, Kravitz, Saul, Heidelberg, John F, Utterback, Terry, Rogers, Yu-Hui, Falcón, Luisa I, Souza, Valeria, Bonilla-Rosso, Germán, Eguiarte, Luis E, Karl, David M, Sathyendranath, Shubha, Platt, Trevor, Bermingham, Eldredge, Gallardo, Victor, Tamayo-Castillo, Giselle, Ferrari, Michael R, Strausberg, Robert L, Nealson, Kenneth, Friedman, Robert, Frazier, Marvin, Venter, J Craig

“…The world's oceans contain a complex mixture of micro-organisms that are for the most part, uncharacterized both genetically and biochemically. We report here…”
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The diploid genome sequence of an individual human by Levy, Samuel, Sutton, Granger, Ng, Pauline C, Feuk, Lars, Halpern, Aaron L, Walenz, Brian P, Axelrod, Nelson, Huang, Jiaqi, Kirkness, Ewen F, Denisov, Gennady, Lin, Yuan, MacDonald, Jeffrey R, Pang, Andy Wing Chun, Shago, Mary, Stockwell, Timothy B, Tsiamouri, Alexia, Bafna, Vineet, Bansal, Vikas, Kravitz, Saul A, Busam, Dana A, Beeson, Karen Y, McIntosh, Tina C, Remington, Karin A, Abril, Josep F, Gill, John, Borman, Jon, Rogers, Yu-Hui, Frazier, Marvin E, Scherer, Stephen W, Strausberg, Robert L, Venter, J Craig

“…Presented here is a genome sequence of an individual human. It was produced from approximately 32 million random DNA fragments, sequenced by Sanger dideoxy…”
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SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer by FLEMING, Nicholas I, JORISSEN, Robert N, DESAI, Jayesh, JONES, Ian T, MCLAUGHLIN, Stephen, WARD, Robyn L, HAWKINS, Nicholas J, RUSZKIEWICZ, Andrew R, MOORE, James, ZHU, Hong-Jian, MARIADASON, John M, BURGESS, Antony W, MOURADOV, Dmitri, BUSAM, Dana, QI ZHAO, STRAUSBERG, Robert L, GIBBS, Peter, SIEBER, Oliver M, CHRISTIE, Michael, SAKTHIANANDESWAREN, Anuratha, PALMIERI, Michelle, DAY, Fiona, SHAN LI, TSUI, Cary, LIPTON, Lara

“…Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium. Colorectal cancers (CRCs)…”
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The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families by Yooseph, Shibu, Sutton, Granger, Rusch, Douglas B, Halpern, Aaron L, Williamson, Shannon J, Remington, Karin, Eisen, Jonathan A, Heidelberg, Karla B, Manning, Gerard, Li, Weizhong, Jaroszewski, Lukasz, Cieplak, Piotr, Miller, Christopher S, Li, Huiying, Mashiyama, Susan T, Joachimiak, Marcin P, van Belle, Christopher, Chandonia, John-Marc, Soergel, David A, Zhai, Yufeng, Natarajan, Kannan, Lee, Shaun, Raphael, Benjamin J, Bafna, Vineet, Friedman, Robert, Brenner, Steven E, Godzik, Adam, Eisenberg, David, Dixon, Jack E, Taylor, Susan S, Strausberg, Robert L, Frazier, Marvin, Venter, J Craig

“…Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering…”
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Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells by Timosenko, Elina, Ghadbane, Hemza, Silk, Jonathan D, Shepherd, Dawn, Gileadi, Uzi, Howson, Lauren J, Laynes, Robert, Zhao, Qi, Strausberg, Robert L, Olsen, Lars R, Taylor, Stephen, Buffa, Francesca M, Boyd, Richard, Cerundolo, Vincenzo

“…Tryptophan degradation is an immune escape strategy shared by many tumors. However, cancer cells' compensatory mechanisms remain unclear. We demonstrate here…”
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Voltage-Gated Na+ Channel SCN5A Is a Key Regulator of a Gene Transcriptional Network That Controls Colon Cancer Invasion by HOUSE, Carrie D, VASKE, Charles J, STUART, Joshua M, LEE, Norman H, SCHWARTZ, Arnold M, OBIAS, Vincent, FRANK, Bryan, LUU, Truong, SARVAZYAN, Narine, IRBY, Rosalyn, STRAUSBERG, Robert L, HALES, Tim G

“…Voltage-gated Na(+) channels (VGSC) have been implicated in the metastatic potential of human breast, prostate, and lung cancer cells. Specifically, the SCN5A…”
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PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer by Day, Fiona L, Jorissen, Robert N, Lipton, Lara, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Christie, Michael, Li, Shan, Tsui, Cary, Tie, Jeannie, Desai, Jayesh, Xu, Zheng-Zhou, Molloy, Peter, Whitehall, Vicki, Leggett, Barbara A, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Gibbs, Peter, Sieber, Oliver M

“…PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated…”
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Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics by Arensburger, Peter, Megy, Karine, Waterhouse, Robert M, Abrudan, Jenica, Amedeo, Paolo, Antelo, Beatriz, Bartholomay, Lyric, Bidwell, Shelby, Caler, Elisabet, Camara, Francisco, Campbell, Corey L, Campbell, Kathryn S, Casola, Claudio, Castro, Marta T, Chandramouliswaran, Ishwar, Chapman, Sinéad B, Christley, Scott, Costas, Javier, Eisenstadt, Eric, Feschotte, Cedric, Fraser-Liggett, Claire, Guigo, Roderic, Haas, Brian, Hammond, Martin, Hansson, Bill S, Hemingway, Janet, Hill, Sharon R, Howarth, Clint, Ignell, Rickard, Kennedy, Ryan C, Kodira, Chinnappa D, Lobo, Neil F, Mao, Chunhong, Mayhew, George, Michel, Kristin, Mori, Akio, Liu, Nannan, Naveira, Horacio, Nene, Vishvanath, Nguyen, Nam, Pearson, Matthew D, Pritham, Ellen J, Puiu, Daniela, Qi, Yumin, Ranson, Hilary, Ribeiro, Jose M.C, Roberston, Hugh M, Severson, David W, Shumway, Martin, Stanke, Mario, Strausberg, Robert L, Sun, Cheng, Sutton, Granger, Tu, Zhijian (Jake), Tubio, Jose Manuel C, Unger, Maria F, Vanlandingham, Dana L, Vilella, Albert J, White, Owen, White, Jared R, Wondji, Charles S, Wortman, Jennifer, Zdobnov, Evgeny M, Birren, Bruce, Christensen, Bruce M, Collins, Frank H, Cornel, Anthony, Dimopoulos, George, Hannick, Linda I, Higgs, Stephen, Lanzaro, Gregory C, Lawson, Daniel, Lee, Norman H, Muskavitch, Marc A.T, Raikhel, Alexander S, Atkinson, Peter W

“…Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as…”
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Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas by QI ZHAO, CABALLERO, Otavia L, DAVIS, Ian D, JONASCH, Eric, TAMBOLI, Pheroze, YUNG, W. K. Alfred, WEINSTEIN, John N, SHAW, Kenna, STRAUSBERG, Robert L, JUN YAO

“…We aim to identify tumor-specific alternative splicing events having potential applications in the early detection, diagnosis, prognosis, and therapy for…”
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Differential evolution of MAGE genes based on expression pattern and selection pressure by Zhao, Qi, Caballero, Otavia L, Simpson, Andrew J G, Strausberg, Robert L

“…Starting from publicly-accessible datasets, we have utilized comparative and phylogenetic genome analyses to characterize the evolution of the human MAGE gene…”
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KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer by TIE, Jeanne, LIPTON, Lara, PICK, Adrian W, KNIGHT, Simon, CARNE, Peter W. G, BERRY, Roger, POLGLASE, Adrian, MCMURRICK, Paul, QI ZHAO, BUSAM, Dana, STRAUSBERG, Robert L, DOMINGO, Enric, DESAI, Jayesh, TOMLINSON, Ian P. M, MIDGLEY, Rachel, KERR, David, SIEBER, Oliver M, GIBBS, Peter, JORISSEN, Robert N, CHRISTIE, Michael, DRUMMOND, Katharine J, THOMSON, Benjamin N. J, USATOFF, Valery, EVANS, Peter M

“…Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases…”
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Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers by Yao, Jun, Caballero, Otavia L, Yung, W K Alfred, Weinstein, John N, Riggins, Gregory J, Strausberg, Robert L, Zhao, Qi

“…Cancer-testis (CT) antigens are potential targets for cancer immunotherapy because of their restricted expression in immune-privileged germ cells and various…”
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From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes by Strausberg, Robert L., Schreiber, Stuart L.

“…The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the development of small molecular probes. The probes are useful for…”
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