Search Results - "Straume, Anne Hege"

Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon by Güralp, Hilal, Skaftnesmo, Kai O., Kjærner-Semb, Erik, Straume, Anne Hege, Kleppe, Lene, Schulz, Rüdiger W., Edvardsen, Rolf B., Wargelius, Anna

“…Genetic introgression of escaped farmed Atlantic salmon ( Salmo salar ) into wild populations is a major environmental concern for the salmon aquaculture…”
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Correction: The novel microRNAs hsa-miR-nov7 and hsa-miR-nov3 are over-expressed in locally advanced breast cancer by Poduval, Deepak, Sichmanova, Zuzana, Straume, Anne Hege, Lønning, Per Eystein, Knappskog, Stian

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Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors by Straume, Anne Hege, Kjaerner-Semb, Erik, Skaftnesmo, Kai Ove, Güralp, Hilal, Lillico, Simon, Wargelius, Anna, Edvardsen, Rolf Brudvik

“…Abstract Background New breeding technologies (NBT) using CRISPR/Cas9-induced homology directed repair (HDR) has the potential to expedite genetic improvement…”
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The novel microRNAs hsa-miR-nov7 and hsa-miR-nov3 are over-expressed in locally advanced breast cancer by Poduval, Deepak, Sichmanova, Zuzana, Straume, Anne Hege, Lønning, Per Eystein, Knappskog, Stian

“…miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs…”
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Author Correction: Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon by Güralp, Hilal, Skaftnesmo, Kai O., Kjærner‑Semb, Erik, Straume, Anne Hege, Kleppe, Lene, Schulz, Rüdiger W., Edvardsen, Rolf B., Wargelius, Anna

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Intratumoral Estrogen Disposition in Breast Cancer by HAYNES, Ben P, STRAUME, Anne Hege, GEISLER, Jürgen, A'HERN, Roger, HELLE, Hildegunn, SMITH, Ian E, LØNNING, Per E, DOWSETT, Mitch

“…The concentration of estradiol (E(2)) in breast tumors is significantly higher than that in plasma, particularly in postmenopausal women. The contribution of…”
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MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells by Aakko, Sofia, Straume, Anne Hege, Birkeland, Einar Elvbakken, Chen, Ping, Qiao, Xi, 'Lønning, Per Eystein', Kallio, Marko J.

“…Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent…”
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Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women by Straume, Anne Hege, Knappskog, Stian, Lønning, Per Eystein

“…► SNPs rs6493497 and rs7176005 in the CYP19 promoter 1.1 are tightly linked in haplotypes. ► rs6493497/rs7176005 do not affect CYP19 mRNA levels in vivo. ►…”
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Highly efficient in vivo C-to-T base editing in Atlantic salmon (Salmo salar) – A step towards aquaculture precision breeding by Raudstein, Mari, Straume, Anne Hege, Kjærner-Semb, Erik, Barvik, Morten, Ellingsen, Ståle, Edvardsen, Rolf Brudvik

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In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.) by Raudstein, Mari, Kjærner-Semb, Erik, Barvik, Morten, Broll, Silje, Straume, Anne Hege, Edvardsen, Rolf Brudvik

“…Genome editing using the CRISPR/Cas system offers the potential to enhance current breeding programs and introduce desirable genetic traits, including disease…”
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Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9-mediated HDR in Atlantic salmon by Straume, Anne Hege, Kjærner-Semb, Erik, Ove Skaftnesmo, Kai, Güralp, Hilal, Kleppe, Lene, Wargelius, Anna, Edvardsen, Rolf Brudvik

“…Precise gene editing such as CRISPR/Cas9-mediated homology directed repair (HDR) can increase our understanding of gene function and improve traits of…”
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Abstract 3082: miR-155-5p expression is associated with response to neoadjuvant paclitaxel treatment of locally advanced breast cancer by Straume, Anne Hege, Birkeland, Einar, Knappskog, Stian, Lønning, Per Eystein

“…Abstract Introduction Resistance to chemotherapy remains a prominent obstacle to cure in cancer. We have previously shown that genetic defects in key pathways…”
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MYC-Induced miR-203b-3p and miR-203a-3p Control Bc1-xL Expression and Paclitaxel Sensitivity in Tumor Cells by Aakko, S, Straume, AH, Birkeland, EE, Chen, P, Qiao, X, Lonning, PE, Kallio, MJ

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Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel by Tambe, Mahesh, Pruikkonen, Sofia, Mäki-Jouppila, Jenni, Chen, Ping, Elgaaen, Bente Vilming, Straume, Anne Hege, Huhtinen, Kaisa, Cárpen, Olli, Lønning, Per Eystein, Davidson, Ben, Hautaniemi, Sampsa, Kallio, Marko J

“…The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We…”
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Correction: The novel microRNAs hsa-miR-nov7 and hsa-miR-nov3 are over-expressed in locally advanced breast cancer by Deepak Poduval, Zuzana Sichmanova, Anne Hege Straume, Per Eystein Lønning, Stian Knappskog

“…[This corrects the article DOI: 10.1371/journal.pone.0225357.]…”
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Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue by Straume, Anne Hege, Knappskog, Stian, Lønning, Per Eystein

“…Breast cancers reveal elevated E2 levels compared to plasma and normal breast tissue. Previously, we reported intra-tumour E2 to be negatively correlated to…”
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Abstract 355: Genetic alterations in 17β-hydroxysteroid dehydrogenase type 2 and 7 correlates with mRNA-expression but not estrogen levels in breast cancer by Straume, Anne Hege, Knappskog, Stian, Lønning, Per Eystein

“…Abstract Background: Estrogens are believed to play an important role in both development and sustained growth of breast cancer. Estradiol (E2), the most…”
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Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity by Berge, Elisabet Ognedal, Staalesen, Vidar, Straume, Anne Hege, Lillehaug, Johan Richard, Lønning, Per Eystein

“…While the majority of RNA transcripts from protein-encoding genes in the human genome are subject to physiological splicing, pathological splicing is…”
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MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells1 by Aakko, Sofia, Straume, Anne Hege, Birkeland, Einar Elvbakken, Chen, Ping, Qiao, Xi, 'Lønning, Per Eystein', Kallio, Marko J.

“…Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent…”
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Elevated levels of the steroidogenic factor 1 are associated with over-expression of CYP19 in an oestrogen-producing testicular Leydig cell tumour by Straume, Anne Hege, Løvås, Kristian, Miletic, Hrvoje, Gravdal, Karsten, Lønning, Per Eystein, Knappskog, Stian

“…Background and objectivesTesticular Leydig cell tumours (LCTs) are rare, steroid-secreting tumours. Elevated levels of aromatase (CYP19 or CYP19A1) mRNA have…”
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