Search Results - "Strauch, Christopher"

Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity by Cruz-Lebrón, Angélica, Johnson, Ramona, Mazahery, Claire, Troyer, Zach, Joussef-Piña, Samira, Quiñones-Mateu, Miguel E., Strauch, Christopher M, Hazen, Stanley L., Levine, Alan D.

“…Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is…”
Get full text

Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration: The Joslin 50-Year Medalist Study by Sun, Jennifer K, Keenan, Hillary A, Cavallerano, Jerry D, Asztalos, Bela F, Schaefer, Ernst J, Sell, David R, Strauch, Christopher M, Monnier, Vincent M, Doria, Alessandro, Aiello, Lloyd Paul, King, George L

“…OBJECTIVE: To assess complication prevalence and identify protective factors in patients with diabetes duration of ≥50 years. Characterization of a…”
Get full text

2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis by Sell, David R, Strauch, Christopher M, Shen, Wei, Monnier, Vincent M

“…We hypothesized that the epsilon-amino group of lysine residues in longlived proteins oxidatively deaminates with age forming the carbonyl compound, allysine…”
Get full text

Loss of HDAC6 alters gut microbiota and worsens obesity by Lieber, Arnon D., Beier, Ulf H., Xiao, Haiyan, Wilkins, Benjamin J., Jiao, Jing, Li, Xinmin S., Schugar, Rebecca C., Strauch, Christopher M., Wang, Zeneng, Brown, J. Mark, Hazen, Stanley L., Bokulich, Nicholas A., Ruggles, Kelly V., Akimova, Tatiana, Hancock, Wayne W., Blaser, Martin J.

“…ABSTRACT Alterations in gut microbiota are known to affect intestinal inflammation and obesity. Antibiotic treatment can affect weight gain by elimination of…”
Get full text

Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice by Zhang, Xue-Song, Yin, Yue Sandra, Wang, Jincheng, Battaglia, Thomas, Krautkramer, Kimberly, Li, Wei Vivian, Li, Jackie, Brown, Mark, Zhang, Meifan, Badri, Michelle H., Armstrong, Abigail J.S., Strauch, Christopher M., Wang, Zeneng, Nemet, Ina, Altomare, Nicole, Devlin, Joseph C., He, Linchen, Morton, Jamie T., Chalk, John Alex, Needles, Kelly, Liao, Viviane, Mount, Julia, Li, Huilin, Ruggles, Kelly V., Bonneau, Richard A., Dominguez-Bello, Maria Gloria, Bäckhed, Fredrik, Hazen, Stanley L., Blaser, Martin J.

“…Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that…”
Get full text

Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli) by Dammann, Philip, Sell, David R, Begall, Sabine, Strauch, Christopher, Monnier, Vincent M

“…Mole-rat of the genus Fukomys are mammals whose life span is strongly influenced by reproductive status with breeders far outliving nonbreeders. This raises…”
Get full text

Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes by Sell, David R, Biemel, Klaus M, Reihl, Oliver, Lederer, Markus O, Strauch, Christopher M, Monnier, Vincent M

“…The extracellular matrix in most tissues is characterized by progressive age-related stiffening and loss of proteolytic digestibility that are accelerated in…”
Get full text

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium by BUCCIARELLI, Loredana G, ANANTHAKRISHNAN, Radha, RAMASAMY, Ravichandran, HWANG, Yuying C, KANEKO, Michiyo, FEI SONG, SELL, David R, STRAUCH, Christopher, MONNIER, Vincent M, SHI FANG YAN, SCHMIDT, Ann Marie

“…RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium Loredana G. Bucciarelli , Radha Ananthakrishnan , Yuying C. Hwang , Michiyo Kaneko , Fei Song…”
Get full text

The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes by BARZILAY, Joshua I, JABLONSKI, Kathleen A, FONSECA, Vivian, SHOELSON, Steven E, GOLDFINE, Allison B, STRAUCH, Christopher, MONNIER, Vincent M

“…OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also…”
Get full text

Favored and disfavored pathways of protein crosslinking by glucose: glucose lysine dimer (GLUCOLD) and crossline versus glucosepane by Nemet, Ina, Strauch, Christopher M, Monnier, Vincent M

“…We describe the isolation and molecular characterization of a novel glucose-lysine dimer crosslink…”
Get full text

Vitamin C Mediates Chemical Aging of Lens Crystallins by the Maillard Reaction in a Humanized Mouse Model by Fan, Xingjun, Reneker, Lixing W., Obrenovich, Mark E., Strauch, Christopher, Cheng, Rongzhu, Jarvis, Simon M., Ortwerth, Beryl J., Monnier, Vincent M.

“…Senile cataracts are associated with progressive oxidation, fragmentation, cross-linking, insolubilization, and yellow pigmentation of lens crystallins. We…”
Get full text

Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes by Sell, David R, Sun, Wanjie, Gao, Xiaoyu, Strauch, Christopher, Lachin, John M, Cleary, Patricia A, Genuth, Saul, Monnier, Vincent M

“…Skin collagen Long Wavelength Fluorescence (LWF) is widely used as a surrogate marker for accumulation of advanced glycation end-products. Here we determined…”
Get full text

Mechanism of Lysine Oxidation in Human Lens Crystallins during Aging and in Diabetes by Fan, Xingjun, Zhang, Jianye, Theves, Mathilde, Strauch, Christopher, Nemet, Ina, Liu, Xiaoqin, Qian, Juan, Giblin, Frank J., Monnier, Vincent M.

“…Oxidative mechanisms during nuclear sclerosis of the lens are poorly understood, in particular metal-catalyzed oxidation. The lysyl oxidation product adipic…”
Get full text

Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging by Pageon, Hervé, Zucchi, Hélène, Dai, Zhenyu, Sell, David R, Strauch, Christopher M, Monnier, Vincent M, Asselineau, Daniel

“…Advanced glycation end products (AGEs) accumulate in the aging skin. To understand the biological effects of individual AGEs, skin reconstructed with collagen…”
Get full text

Impaired left ventricular function and myocardial blood flow reserve in patients with long-term type 1 diabetes and no significant coronary artery disease: associations with protein glycation by Sveen, Kari Anne, Nerdrum, Tone, Hanssen, Kristian F, Brekke, Magne, Torjesen, Peter A, Strauch, Christopher M, Sell, David R, Monnier, Vincent M, Dahl-Jørgensen, Knut, Steine, Kjetil

“…Our aims were to study left ventricular (LV) function and myocardial blood flow reserve (MBFR) in long-term type 1 diabetes and associations with advanced…”
Get more information

Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls by Sell, David R, Strauch, Christopher M, Shen, Wei, Monnier, Vincent M

“…The epsilon-amino group of lysyl residues oxidatively deaminates in the presence of alpha-dicarbonyl sugars and redox-active metals forming alpha-aminoadipic…”
Get full text

Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice by Fan, Xingjun, Xiaoqin, Liu, Potts, Breshey, Strauch, Christopher M, Nemet, Ina, Monnier, Vincent M

“…Previous experiments from our laboratory showed that the oral intake of selected guanidino compounds could block the formation of crystallin-bound advanced…”
Get full text

Aging, Diabetes, and Renal Failure Catalyze the Oxidation of Lysyl Residues to 2-Aminoadipic Acid in Human Skin Collagen by Sell, David R., Strauch, Christopher M., Shen, Wei, Monnier, Vincent M.

“…The ɛ‐amino group of lysyl residues oxidatively deaminates in the presence of α‐dicarbonyl sugars and redox‐active metals forming α‐aminoadipic…”
Get full text

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats by Mustata, Georgian T., Rosca, Mariana, Biemel, Klaus M., Reihl, Oliver, Smith, Mark A., Viswanathan, Ashwini, Strauch, Christopher, Du, Yunpeng, Tang, Jie, Kern, Timothy S., Lederer, Markus O., Brownlee, Michael, Weiss, Miriam F., Monnier, Vincent M.

“…Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats Improved Retinopathy and Renal Mitochondrial Defects but…”
Get full text

Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix by Sell, David R., Biemel, Klaus M., Reihl, Oliver, Lederer, Markus O., Strauch, Christopher M., Monnier, Vincent M.

“…The extracellular matrix in most tissues is characterized by progressive age-related stiffening and loss of proteolytic digestibility that are accelerated in…”
Get full text